Potential antimicrobial and antibiofilm efficacy of essential oil nanoemulsion loaded polycaprolactone nanofibrous dermal patches

El‐Naggar, Mehrez E.; Abdelgawad, Abdelrahman M.; Abdel-Sattar, R.; Gibriel, Abdullah Ahmed; Hemdan, Bahaa A.

doi:10.1016/j.eurpolymj.2022.111782

Cited by 16 publications

(8 citation statements)

References 49 publications

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“…All injected tubes were marinated at 35 °C and 80% relative humidity at a constant position to allow bacterial adhesion over the cryogel. Following that, at 0 day of incubation, the bacterial adhesion and biofilm formation over each swatch was scraped according to Hemdan et al 41 After each interval, the cell viability of detached biofilm was performed and used to calculate the mean colony forming units (CFU cm −2 ).…”

Section: Methodsmentioning

confidence: 99%

Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

Elsherbiny¹,

Abdelgawad²,

Hemdan³

et al. 2023

J. Mater. Chem. B

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Section: Methodsmentioning

confidence: 99%

Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

Elsherbiny¹,

Abdelgawad²,

Hemdan³

et al. 2023

J. Mater. Chem. B

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“…PCL would also be used by researchers for electrospinning. Mehrez E. et al blended PCL and peppermint oil (PO) nanoemulsion to prepare uniform nano-sized PO nanoemulsion, as shown in Figure 7 [ 147 ]. The electrospinning technique was used to prepare PCL nanofibrous mats loaded with PO nanoemulsion.…”

Section: Polymers For Antifungal Drug Delivery Nanosystemsmentioning

confidence: 99%

“… Potential antimicrobial and antibiofilm efficacy of essential oil nanoemulsion loaded polycaprolactone nanofibrous dermal patches Published by Elsevier, 2023 [ 147 ]. …”

Section: Figurementioning

confidence: 99%

Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs

et al. 2023

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Nanosystems-based antifungal agents have emerged as an effective strategy to address issues related to drug resistance, drug release, and toxicity. Among the diverse materials employed for antifungal drug delivery, polymers, including polysaccharides, proteins, and polyesters, have gained significant attention due to their versatility. Considering the complex nature of fungal infections and their varying sites, it is crucial for researchers to carefully select appropriate polymers based on specific scenarios when designing antifungal agent delivery nanosystems. This review provides an overview of the various types of nanoparticles used in antifungal drug delivery systems, with a particular emphasis on the types of polymers used. The review focuses on the application of drug delivery systems and the release behavior of these systems. Furthermore, the review summarizes the critical physical properties and relevant information utilized in antifungal polymer nanomedicine delivery systems and briefly discusses the application prospects of these systems.

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“…Therefore, nanoemulsion is an emerging approach to enhance the delivery of bioactive compounds and essential oils in the depth of the skin. 20 The nanoscale droplets (1−200 nm) of nanoemulsions enable them for longer stability, better penetration, and targeted delivery. 21 The oily phase of the nanoemulsions increases the interaction with the lipid layer of the skin, allowing for the effective delivery of the targeted components.…”

Section: Introductionmentioning

confidence: 99%

“…For the past few decades, nanoemulsions have been utilized in the pharmaceutical and cosmetic industries, but skincare products do not contain those bioactive ingredients that balance fatty acids in the lipid layer of burned and rough skin. , The cosmetic business focuses on using topical and oral applications of fatty acids and ceramides to make skin smoother and more compact. , Many commercial skin protectants contain a variety of nutrients, including fatty acids, carotenoids, ubiquinones, polyphenols, and water- and fat-soluble vitamins, but they fall short of providing the additional nourishment that the skin needs. Therefore, nanoemulsion is an emerging approach to enhance the delivery of bioactive compounds and essential oils in the depth of the skin . The nanoscale droplets (1–200 nm) of nanoemulsions enable them for longer stability, better penetration, and targeted delivery .…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of Sandalwood Oil-Based Nanoemulsion to Intensify the Fatty Acid Composition in Burned and Rough Skin

Giri,

Pandey,

Shukla

et al. 2024

ACS Omega

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The restoration process of burned and rough skin takes a long time and remains a critical challenge. It can be repaired through a combination of proper care, hydration, and topical therapies. In this study, a novel nanoemulsion was synthesized through the high-energy ultrasonication method. A total of five nanoemulsions (NE1−5) were prepared with varying concentrations of sandalwood oil, a nonionic surfactant (polysorbate 80), and water. Among them, NE3 had a number of appropriate physicochemical characteristics, such as physiological pH (5.58 ± 0.09), refractive index (∼1.34), electrical conductivity (115 ± 0.23 mS cm −1 ), and transmittance (∼96.5%), which were suitable for skin care applications. The NE3 had a strong surface potential of −18.5 ± 0.15 mV and a hydrodynamic size of 61.99 ± 0.22 nm with a polydispersity index of 0.204. The structural integrity and a distinct droplet size range between 50 and 100 nm were confirmed by transmission electron microscopic analysis. The skin regeneration and restoration abilities of synthesized nanoemulsions were examined by conducting an in vivo study on Sprague− Dawley rats. Exposure to NE3 significantly increased the healing process in burned skin as compared to untreated control and nonemulsified sandalwood oil. In another set of experiments, the NE3-treated rough skin became softer, smoother, and less scaly than all other treatments. Enhanced fatty acids, i.e., palmitic acid, stearic acid, and cholesterol, were recorded in NE3-supplemented burned and rough skin compared to the untreated control. The NE3 had outstanding compatibility with key components of skincare products without any stability issues. Its biocompatibility with the cellular system was established by the negligible generation of reactive oxygen species (ROS) and a lack of genotoxicity. Considering these results, NE3 can be used in cosmetic products such as creams, lotions, and serums, allowing industries to achieve improved product formulations and provide better healthcare benefits to humanity.

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Potential antimicrobial and antibiofilm efficacy of essential oil nanoemulsion loaded polycaprolactone nanofibrous dermal patches

Cited by 16 publications

References 49 publications

Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs

Facile Fabrication of Sandalwood Oil-Based Nanoemulsion to Intensify the Fatty Acid Composition in Burned and Rough Skin

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