Dislipidemia merupakan salah satu faktor risiko dari non alcoholic fatty liver disease (NAFLD). NAFLD mempunyai karakteristik steatosis hepatik, hepatocyte ballooning, inflamasi lobular, dan fibrosis. Kandungan flavonoid pada Citrus limon dipercaya dapat mencegah steatosis hepatik. Tujuan penelitian ini mengetahui pengaruh fraksi air buah lemon terhadap gambaran morfologi jaringan hati mencit tua yang diberi pakan tinggi lemak. Penelitian ini merupakan penelitian eksperimental dengan subjek penelitian adalah mencit (Mus musculus) jantan galur DDY tua yang dibagi menjadi empat kelompok secara acak, terdiri atas kelompok kontrol dan tiga kelompok perlakuan dengan konsentrasi fraksi air buah lemon 20,6; 41,2; 82,4 mg/20 gram BB mencit. Data jumlah hepatosit dengan droplet lemak dan hepatocyte ballooning dianalisis menggunakan uji ANOVA dan Uji Kruskal Willis. Terdapat perbedaan jumlah hepatosit dengan droplet lemak (p=0,063) dan hepatosit yang mengalami pembengkakan (p=0,109) antara kelompok kontrol dan kelompok perlakuan. Simpulan penelitian ini adalah fraksi air buah lemon dapat mencegah hepatocyte ballooning dan pembentukan droplet lemak pada hepatosit mencit tua yang diberikan pakan tinggi lemak. PROTECTIVE EFFECT OF WATER FRACTION OF LEMON ON HIGH-FAT DIET-INDUCED LIVER INJURY IN OLD MICEDyslipidemia is one of the risk factors of non alcoholic fatty liver disease (NAFLD). NAFLD is characterized by hepatic steatosis, hepatocyte ballooning, lobular inflammation, and fibrosis. Flavonoid in Citrus limon is believed to prevent hepatic steatosis. The aim of this study is to know the protective effect of lemon’s water fraction on high-fat diet-induced liver injury in old mice. This was an experimental study with old male mice (Mus musculus) DDY strain divided into four groups randomly, consisting of control group and three groups given with water fraction of lemon at concentration 20.6; 41.2; 82.4 mg/20 gram mice body weight. Total count of hepatocytes with fat droplets and hepatocytes ballooning were analyzed using ANOVA and Kruskal Willis tests. There are differences in the amount of hepatocytes with fat droplets (p=0.063) and hepatocytes ballooning (p=0.109) between the control group and the treatment group. The conclusion of this study is lemon’s water fraction can prevent the formation of hepatocyte ballooning and fat droplet in old mice’s hepatocyte fed by high-fat diet.
The study aim was analyzed the potential of semi polar compounds from lemon-local on old mice lipid profile with high fat dietary. Experimental study using DDY mice, males, 50−55 weeks. Five of 30 mice were sacrificed before treatment (group 6), group 1 (negative control), groups 2, 3, 4 and 5 were fed high fat dietary, group 3, 4 and 5 were treated doses 1, 2 and 3, respectively, orally. Parameters measured were body weight, HDL, TAG, total cholesterol. The results showed body weight of mice were above normal and dose 2 treatment cause weight loss (p=0.658). The highest cholesterol level was in positive control and the lowest was in the group given doses 2 (p=0.042). The highest triglycerides level was in the pretreatment group and the lowest was in the group given doses 2 (p=0.148). The highest HDL was in the positive group and the lowest was in the group given doses 2 (p=0.278). Semi polar compound from lemon-local at dose 2 could be regulated profile lipid on old mice with high fat dietary. This research needs to be improved, especially biomechanism of active substances.
Background: Infertility can be caused by prolonged use of paracetamol that leads to a decrease in the sperm concentration, motility, and morphology. Dates (Phoenix Dactilyfera L) have natural antioxidant effects through several mechanisms, such as neutralizing free radicals, against NO, OH, and H2O2, and also preventing lipid peroxidation. This study aimed to investigate the effect of dates on sperm concentration, motility, and morphology. Methods: An experimental study was conducted in the
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