Effect of Dates (Phoenix Dactilyfera L) on Male Infertility

Wahyudi, Semalina; Ekowati, R. A. Retno; Rinaldi, Andi

doi:10.15850/amj.v2n1.437

Cited by 4 publications

(2 citation statements)

References 5 publications

(3 reference statements)

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“…It first weakens the sperm membrane and reduces its motility. Second, ROS has the ability to change sperm DNA, leading to a genetic abnormality (Wahyudi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The Possible Protective Role of N-acetylcysteine against Testicular Toxicity Induced by Paracetamol Overdose in Adult Male Rats

Mohamed,

Moussa,

Abd El-Gawad

et al. 2024

mjbs

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Many substances, even medicines with proven therapeutic benefits, can harm cells by metabolically activating them into extremely reactive substances. Paracetamol is one of the most widely used over-the-counter analgesics. This study examines the harmful effects of paracetamol on the lipid peroxidation process in testes homogenates as well as enzymatic and non-enzymatic antioxidant activities. Also, examine the effects on male hormones and sperm count. The study also assesses if N-acetylcysteine protects against testicular damage induced by paracetamol excess. Forty mature male albino rats were created. Group 1 as a control, Group 2 paracetamol (650 mg/kg), Group 3 NAC (150 mg/kg), and Group 4 both paracetamol and NAC. Samples of blood and testicles were taken after 15 days to measure sperm and testicular biochemistry. Testicular tissues had considerably higher amounts of MDA and H2O2. SOD, GSH, and CAT levels significantly decreased. FSH and LH rise. On the other hand, testosterone levels decrease following paracetamol exposure. The administration of NAC generated changes in testosterone levels, FSH, LH, and antioxidant enzymes. The sperm morphology showed an increase in abnormalities but a significant decrease in motility and count. NAC effectively lowers the toxicity of paracetamol to the testicles while restoring biomarkers associated with normal testicular function.

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“…It first weakens the sperm membrane and reduces its motility. Second, ROS has the ability to change sperm DNA, leading to a genetic abnormality (Wahyudi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The Possible Protective Role of N-acetylcysteine against Testicular Toxicity Induced by Paracetamol Overdose in Adult Male Rats

Mohamed,

Moussa,

Abd El-Gawad

et al. 2024

mjbs

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“…These compounds protect male sperm from oxidation, increase their number and improve their quality. Pollen also increases female fertility and egg production (Wahyudi et al, 2015;Tahvilzadeh et al, 2016). As the natural agent for fertility improvement, a preliminary work stated that palm pollen could enhance fertility factors, whereas astragalus Officinale showed adverse effects on the gonads and sperm in rats (Mehraban et al, 2014).…”

Section: Fertilitymentioning

confidence: 99%

Nutritional values, Nutraceutical properties, and health benefits of Arabian Date Palme fruit

et al. 2023

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The date palm is widely known as a richer nutritional source and natural medical agent. Date fruit is a major source of carbohydrates and dietary fiber, and it has contains proteins, minerals, vitamins, phenolic compounds, carotenoids, sterols, and triterpenoids. The beneficial potential of this fruit is well known in Arab countries and even in the world. Date fruit has many health benefits such as Glucose-lowering potential, anti-cancer activity, antioxidant activity, hypocholesterolemia-lowering potential, antimicrobial activity, anti-inflammatory activity, bone stimulating activity, which is attributed to the existence of bioactive substances such as carotenoids, polyphenols, triterpenoids, flavonoids, sterols, and some vitamins and minerals. Overall, Arabian date palms’ nutritional values and pharmacological activities remain to be explained. Thus, this study states the history, nutritional and health effects of Arabian date palm, highlighting the possibility of palm date components developing novel beneficial approaches for managing the above mentioned illnesses. Keywords: Arabian date palm; Arab’s tree; Nutritional values; Pharmacological activities

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