Semi polar compounds from lemon-local: Focus on lipid metabolism

Abstract

The study aim was analyzed the potential of semi polar compounds from lemon-local on old mice lipid profile with high fat dietary. Experimental study using DDY mice, males, 50−55 weeks. Five of 30 mice were sacrificed before treatment (group 6), group 1 (negative control), groups 2, 3, 4 and 5 were fed high fat dietary, group 3, 4 and 5 were treated doses 1, 2 and 3, respectively, orally. Parameters measured were body weight, HDL, TAG, total cholesterol. The results showed body weight of mice were above normal and dose 2 treatment cause weight loss (p=0.658). The highest cholesterol level was in positive control and the lowest was in the group given doses 2 (p=0.042). The highest triglycerides level was in the pretreatment group and the lowest was in the group given doses 2 (p=0.148). The highest HDL was in the positive group and the lowest was in the group given doses 2 (p=0.278). Semi polar compound from lemon-local at dose 2 could be regulated profile lipid on old mice with high fat dietary. This research needs to be improved, especially biomechanism of active substances.

Effect of Lissachatina fulica chitosan on the antioxidant and lipid profile of hypercholesterolemic male Wistar rats

“…The MDA level increases in Wistar rats under hypercholesterolemic conditions (Aryanugraha et al, 2012;Valko et al, 2007;Wahjuni, 2014;Widhiantara et al, 2021). MDA is the final product of the lipid peroxidation process and can cause free compounds or bonds to tissues (Aryanugraha et al, 2012;Michalski et al, 2008;Yui et al, 2021;Yulianti et al, 2020). High plasma MDA indicates an increase in free radical activity and a decrease in superoxide dismutase (SOD) enzyme (Lecumberri et al, 2007;Wahjuni, 2014).…”