Pengaruh Fraksi Air Buah Lemon terhadap Gambaran Morfologi Jaringan Hati Mencit Tua yang Diberi Pakan Tinggi Lemak

Mundiri, Nur Azmiati; Damayanti, Meta Maulida; Tejasari, Maya; Furqaani, Annisa Rahmah; Ekowati, R. A. Retno

doi:10.29313/jiks.v1i1.4321

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…The ability of fatty liver cells will be disrupted. 20 The limitation of this study is that the dose of a high-fat diet given to experimental rats only had one dose variant, namely 3 mL/head/ day. Giving various doses can see how the dose affects the histopathological picture of the liver.…”

Section: Discussionmentioning

confidence: 98%

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver

Desmawati

Nisa

Afriani

2022

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Indonesia is facing increased consumption of calorie-dense foods, such as fast food, among its society. Changes in diet and physical activities towards unhealthy ones can result in an imbalanced lifestyle, leading to various consequences, including hyperlipidemia. Pregnant women experience significant increases in plasma concentrations of lipids, lipoproteins, and apolipoproteins. Excessive cholesterol levels in pregnant women will result in the formation of fat in the liver. The purpose of this study was to determine the effect of a high-fat diet to pregnant Wistar rats (Rattus norvegicus) on the histopathological features of the liver. A true experimental with post test only control group design was applied in this study, which was conducted from August 2020 to November 2021. Fourteen (14) pregnant female rats were divided into two groups. The first group of rats was fed with a high-fat diet, while the second group, which was the control group, was given a standard diet. The high-fat diet used was 3 mL/rat/day beef brain. After the rats delivered their litters, the rats’ livers were retrieved, then examined histopathologically under a microscope. This research was conducted from No fatty liver was identified in the control group or the treatment group. Hence, a high-fat diet does not affect the liver histopathological features in pregnant Wistar rats.

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Section: Discussionmentioning

confidence: 98%

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver

Desmawati

Nisa

Afriani

2022

mkb

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Histopatologi Hepar Tikus Dengan Induksi Pakan Tinggi Lemak Setelah Pemberian Biji Mahoni

Sijabat,

Isdadiyanto,

Sitasiwi

2024

J. Ilmu. Pertan. Indones.

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High accumulation of lipids in hepatocytes can trigger an increase in the production of radical compounds, leading to fatty liver disease. This condition induces histological changes in the liver, especially in hepatocytes, and affects the surrounding structures. Mahogany seeds have the potential to act as a hypolipidemic agent in treating fatty liver. Mahogany seeds are known to contain phytochemical compounds which act as antioxidants. This study aimed to determine liver histopathology of rats by inducing high-fat diet after giving mahogany seeds ethanol extract which was observed through the percentage of steatosis, hepatocyte diameter, and hepatosomatic index. This study involved thirty male Sprague Dawley rats, divided into 6 groups: P0 (given commercial feed), P1 (given high-fat diet), P2 (given high-fat diet and simvastatin at a dose of 8 mg/200 g BW), P3, P4, and P5 (given high-fat diet and mahogany seeds ethanol extract at a dose of 14, 28, and 56 mg/200 g BW). The results showed that the hepatosomatic index among all treatment groups did not differ significantly; however, the percentage of steatosis and hepatocyte diameter in the groups given mahogany seeds ethanol extract significantly differed from the group given only high-fat feed. Based on these results, it can be concluded that mahogany seed ethanol extract can maintain the histological structure of the liver in male Sprague Dawley rats with fatty liver. Keywords: hepatocyte, hepatosomatic index, high-fat diet, mahogany seeds, steatosis

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Pengaruh Fraksi Air Buah Lemon terhadap Gambaran Morfologi Jaringan Hati Mencit Tua yang Diberi Pakan Tinggi Lemak

Cited by 2 publications

References 9 publications

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver

Effect of High Fat Diet on Histopathological Appearance of Pregnant Wistar Rat’s Liver

Histopatologi Hepar Tikus Dengan Induksi Pakan Tinggi Lemak Setelah Pemberian Biji Mahoni

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