Osteoarthritis (OA) arises from imbalance of cartilage metabolism between the synthesis and degradation of type II collagen by the chondrocyte. Collagen type II degradation is characterized by increase in the biomarker of Ctelopeptide fragment of type II collagen (CTX-II), while the anabolic process of cartilage is characterized by an increase in the biosynthesis of procollagen amino terminal N-propeptide type IIA (PIIANP). Platelet derived growth factor (PDGF) with Hyaluronic Acid (HA) as a potent growth factor can be used to stimulate the higher formation of chondrocyte and PIIANP levels and lower CTX-II levels in mouse knee osteoarthritis model.

Background: Lower Urinary Tract Symptoms (LUTS) after Transurethral Resection of the Prostate (TURP) occur in one-third of Benign Prostatic Hyperplasia (BPH) patients, may be caused by persistent prostatic inflammation and fibrosis. Objective: This study aims to evaluate the role of inflammation and fibrosis in pathological mechanism of LUTS among patients with BPH who underwent TURP by assessing their PSA, TNF-α, and TGF-β level. Design, Setting, and Participant: Data in this study were analyzed with the 2-way hypothesis. The study used odds ratio to define the risk factors of LUTS after TURP. The samples of the study are BPH patients after TURP aged 50-80 years old. Interventions: No intervention(s). Outcome Measurements and Statistical Analysis: The data analyzed using SPSS version 21.0 for Windows. Results and Limitations: There were 34 cases of LUTS and 42 controls without LUTS. We found that there were an increased levels of TNF-α (> 46.95 pg/ml) (OR 55.6, 95% Confidence Interval [CI] 11.1-278.4, p=0.00) and TGF-β (> 207.63 pg/ml) (OR 16.7, 95%CI 5.3-52.8, p=0.00). The result of multiple linear logistic regression analysis obtained equation Y= 0.033 x TNF-α + 0.031 x TGF-β. Population Attributable Risk (PAR) % TNF-α is 60%, PAR % TGF-β is 53%. Conclusion: Combination of elevated levels of TNF-α (>46.95 pg/ml) and TGF-β (>207.63) in prostate tissue is the risk factors for the occurrence of LUTS after TURP. Patient Summary: In this study, we enrolled 76 patients who were diagnosed with BPH and urinary retention. After TURP, there were 34 cases of LUTS and 42 controls without LUTS. We found that the levels of TNF-α and TGF-β between cases and controls were significantly different. We conclude that the combination of elevated levels of TNF-α and TGF-β in prostate tissue is the risk factors for the occurrence of LUTS after TURP.

The aim of this study was to find out the influence of vitamin-mineral supplementation on digestibility and rumen fermentation in Bali cattle. The randomized block design with 4 treatments and 4 replications were used in the research. In this study was used 16 Bali cattle with body weight around 295.31+23.07 kg. Rations used in the treatments were Treatment A (control): rice straw ad libitum plus commercial feed; Treatment B: Treatment A ration plus 0.2% vitamin-mineral in commercial feed; Treatment C: Treatment A ration plus 0.3% vitamin-mineral in commercial feed, and Treatment D: Treatment A ration plus 0.4% vitamin-mineral in commercial feed. Parameters measured were nutrient digestibility, rumen metabolites and urinary allantoin. The results showed that supplementation of vitamin-mineral at 0.2 -0.4% in commercial feed did not increase the digestibility of dry matter, organic matter, crude protein and crude fiber, except for dry matter and organic matter digestibilities at 0.2% supplementation (p<0.05). However, the vitamin-mineral supplementation increased concentrations of partial VFA and ammonia as well as for methane gas production, except for VFA and ammonia at 0.4% level. Vitamin-mineral supplementation at 0.2-0.4% level did not affected pH value of rumen fluid and urinary allantoin.

Spondilitis tuberkulosis adalah infeksi pada tulang belakang yang disebabkan oleh kuman Mycobacterium tuberculosis. Sejak obat anti tuberkulosis dikembangkan dan peningkatan kesehatan masyarakat, tuberkulosis tulang belakang menjadi menurun di daerah negara industri, meskipun tetap menjadi penyebab yang bermakna di negara berkembang. Gejala yang ditimbulkan antara lain demam, keringat terutama malam hari, penurunan berat badan dan nafsu makan, terdapat masa di tulang belakang, kiposis, kadang-kadang berhubungan dengan kelemahan dari tungkai dan paraplegi. Spondilitis tuberkulosis dapat menjadi sangat destruktif. Berkembangnya tuberkulosis di tulang belakang berpotensi meningkatkan morbiditas, termasuk defisit neurologi yang permanen dan deformitas yang berat. Pengobatan medikamentosa atau kombinasi antara medis dan bedah dapat mengendalikan penyakit spondilitis tuberkulosis pada beberapa pasien

Amputation still considered as primary choice of malignancy treatment in distal tibia. Bone recycling with liquid nitrogen for reconstruction following resection of malignant bone tumours offers many advantages. We presented four patients with osteosarcoma, Ewing sarcoma, adamantinoma and recurrent giant cell tumour over distal tibia. All of the patients underwent wide excision and bone recycling using liquid nitrogen as bone reconstruction. The mean functional Musculoskeletal Tumor Society (MSTS) score was 75% with no infection and local recurrent. The reconstruction provides good local control and functional outcome.

Background Low back pain (LBP) is a common clinical condition encountered by most physicians, but the cause and risk factors are still unclear. Cytokines such as IL-6 play an important role in cartilage degeneration, but the role of IL-6 in osteoarthritis (OA) is still debatable. Herein, we aimed to determine the association between high IL-6 levels and lumbar OA in patients older than 55 years with LBP. Method This was a case–control study. Patients included 10 men and 14 women over 55 years of age with lumbar OA. The control group comprised 10 men and 14 women over 55 years of age without lumbar OA. IL-6 analysis was performed for all study subjects. Result The mean age of patients in the case group for both men and women were 67.7±10.4 and 74.4±10.5 years, while that of the control group for both men and women were 67.7±6.3 and 64.9±6.1 years, respectively. Body mass index was not statistically significantly different between the two groups (men and women). Chi-squared analysis showed no statistically significant differences between nutritional status and lumbar OA. Conclusion The probability of lumbar OA in LBP patients with high IL-6 levels (>6.60 pg/ mL) is five times greater than in those with low IL-6 levels ( P =0.009). Women with high IL-6 levels have a 6.9-times greater probability of developing lumbar OA than men ( P =0.03).

Giant cell tumor (GCT) remains as major health problem. GCT which located at the lower end of the radius tends to be more aggressive. Wide excision and reconstruction of the wrist in stage 3 of distal radius GCT lesion is an optimal modality to prevent tumor recurrence. However, dislocation often occurs as its complication. We are reporting patient with GCT of distal radius treated with wide excision and reconstruction using nonvascularized fibular graft and the addition of hernia mesh. Circumferential non-absorbable polypropylene hernia mesh was applied, covered radioulnar joint and volar aspect of radius, and served as additional support to prevent dislocation. During five years and two months of follow-up, we found no dislocation in our patient. Furthermore, good functional outcome was obtained. Our finding suggests that the addition of hernia mesh after wide excision and reconstruction with nonvascularized fibular graft may benefit to prevent dislocation and provides an excellent functional outcome.

Latar belakang: Taekwondo merupakan bela diri yang banyak menggunakan anggota gerak bawah terutama pergelangan kaki sehingga sering terjadi fungsional ankle instabilitas (FAI). FAI terjadi akibat adanya gangguan dari postural kontrol, keseimbangan dinamis dan fungsi otot. Salah satu latihan yang dapat dipergunakan adalah star excursion balance exercise, namun masih ada kekurangan dalam kontrol postural akibat tidak terjadi aktivasi otot core untuk pembentukan postural stabilisasi. Tujuan: Untuk membuktikan penambahan core stability pada star excursion balance exercise lebih meningkatkan keseimbangan dinamis dan menurunkan fungsional ankle instabilitas daripada star excursion balance exercise pada bela diri taekwondo. Metode: Rancangan penelitian ini adalah randomized pretest-postest control group design, Kelompok 1 mendapatkan star excursion balance exercise dan Kelompok  2  mendapatkan core stability dan star excursion balance exercise. Fungsional ankle instabilitas diukur menggunakan cumberland ankle instability tool (CAIT) dan keseimbangan dinamis menggunakan star excursion balance test (SEBT). Dilakukan 3 kali seminggu selama 6 minggu. Hasil: Peningkatan SEBT sebelum pelatihan pada Kelompok  1 sebesar 86,4±6,3 cm, setelah pelatihan sebesar 92,3±6,7cm dan pada Kelompok 2 sebelum sebesar 86,2±6,1 cm, setelah pelatihan sebesar 96,7±7,9 cm.  Penurunan fungsional ankle instabilitas dari peningkatan nilai CAIT sebelum pelatihan pada Kelompok 1 sebesar 20,4±1,8, setelah pelatihan sebesar 23,4±2,1 dan pada Kelompok 2 sebelum sebesar 20,3±2,8, setelah pelatihan sebesar 25,0±1,9. Perbedaan peningkatan keseimbangan dinamis pada Kelompok 1 dan 2 bermakna (p<0,05). Perbedaan penurunan FAI pada Kelompok 1 dan 2 bermakna (p<0,05). Kesimpulan: Penambahan core stability pada star excursion balance exercise lebih meningkatkan keseimbangan dinamis dan menurunkan fungsional ankle instabilitas daripada star excursion balance exercise pada bela diri taekwondo.   Kata kunci: fungsional ankle instabilitas, keseimbangan dinamis, star excursion balance exercise, core stability.