&lt;p&gt;High IL-6 level as a marker of lumbar osteoarthritis in patients older than 55 years with low back pain&lt;/p&gt;

Pratama, Dewa Gede Kurnia; Suyasa, I Ketut; Astawa, Putu; Lestari, Anak Agung Wiradewi

doi:10.2147/orr.s188678

Cited by 4 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic inflammatory progression in OA is regulated through multiple cytokine networks, including the IL-6 pathway. Previous research has documented increased IL-6 concentrations in sera and synovial fluid from OA patients (Pratama, Suyasa, Astawa, & Lestari, 2019). Moreover, inhalation of air pollutants leads to oxidative damage and inflammation, and cytotoxic responses in the body, including cellular IL-6 production (Chau & Wang, 2020).…”

mentioning

confidence: 99%

PM2.5 facilitates IL‐6 production in human osteoarthritis synovial fibroblasts via ASK1 activation

Liu

Ching

Lin

et al. 2020

Journal Cellular Physiology

View full text Add to dashboard Cite

Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by synovial inflammation. Interleukin-6 (IL-6) is a key proinflammatory cytokine in OA progression. Particulate matter 2.5 (PM2.5) exposure increases the risk of different diseases, including OA. Up until now, no studies have described any association between PM2.5 and IL-6 expression in human OA synovial fibroblasts (OASFs). Here, our data show that PM2.5 concentration-and timedependently promoted IL-6 synthesis in human OASFs. We also found that reactive oxygen species (ROS) generation potentiated the effects of PM2.5 on IL-6 production. ASK1, ERK, p38, and JNK inhibitors reduced PM2.5-induced increases of IL-6 expression. Treatment of OASFs with PM2.5 promoted phosphorylation of these signaling cascades. We also found that PM2.5 enhanced c-Jun phosphorylation and its translocation into the nucleus. Thus, PM2.5 increases IL-6 production in human OASFs via the ROS, ASK1, ERK,

show abstract

mentioning

confidence: 99%

PM2.5 facilitates IL‐6 production in human osteoarthritis synovial fibroblasts via ASK1 activation

Liu

Ching

Lin

et al. 2020

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…IL6, derived from macrophages, chondrocytes, and osteoclasts can increase inflammatory cells in synovial tissue and stimulate chondrocyte proliferation. Dewa GK et al found that the incidence of lumbar OA in patients with high levels of IL6 was five times higher than in patients with low levels of IL6, suggesting that IL6 is closely related to the occurrence of OA ( Pratama et al, 2019 ). TNF, derived from macrophages and chondrocytes, serves as an indispensable mediator in the degradation of the cartilage matrix and is closely related to synovitis, and it has been widely reported that many drugs interact with TNF to make an effect on OA.…”

Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

et al. 2021

View full text Add to dashboard Cite

Purpose: The external preparation of the Tibetan medicine formula, Baimai ointment (BMO), has great therapeutic effects on osteoarthritis (OA). However, its molecular mechanism remains almost elusive. Here, a comprehensive strategy combining network pharmacology and molecular docking with pharmacological experiments was adopted to reveal the molecular mechanism of BMO against OA.Methods: The traditional Chinese medicine for systems pharmacology (TCMSP) database and analysis platform, traditional Chinese medicine integrated database (TCMID), GeneCards database, and DisGeNET database were used to screen the active components and targets of BMO in treating OA. A component–target (C-T) network was built with the help of Cytoscape, and the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment through STRING. Autodock Tools which was used to dock the key components and key target proteins was analyzed. Animal experiments were performed to verify the key targets of BMO. Hematoxylin–eosin and toluidine blue staining were used to observe the pathology of joints. Protein expression was determined using enzyme-linked immunosorbent assay.Results: Bioactive compounds and targets of BMO and OA were screened. The network analysis revealed that 17-β-estradiol, curcumin, licochalone A, quercetin, and glycyrrhizic acid were the candidate key components, and IL6, tumor necrosis factor (TNF), MAPK1, VEGFA, CXCL8, and IL1B were the candidate key targets in treating OA. The KEGG indicated that the TNF signaling pathway, NF-κB signaling pathway, and HIF-1 signaling pathway were the potential pathways. Molecular docking implied a strong combination between key components and key targets. The pathology and animal experiments showed BMO had great effects on OA via regulating IL6, TNF, MAPK1, VEGFA, CXCL8, and IL1B targets. These findings were consistent with the results obtained from the network pharmacology approach.Conclusion: This study preliminarily illustrated the candidate key components, key targets, and potential pathways of BMO against OA. It also provided a promising method to study the Tibetan medicine formula or external preparations.

show abstract

“…(79,80) Certainly, findings that Tai Chi Chih decreased high plasma levels of IL-6, (42) indicates that Tai Chi might be a valuable therapy for alleviating systemic infl ammation and arresting OA progression. (81)…”

Section: Infl Ammationmentioning

confidence: 99%

Beneficial Effects and Potential Mechanisms of Tai Chi on Lower Limb Osteoarthritis: A Biopsychosocial Perspective

Zhuang

Chen

Han

et al. 2021

Chin. J. Integr. Med.

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most prevalent form of arthritis, and the most commonly influenced appendicular joints are knees, hips and fi ngers. (1) The muscle atrophy, cartilage degradation, joint instability and synovial inflammation lead to compromised physical function and pain. (2) Tai Chi involves slow and gentle motions to be particularly suitable to arthritic individuals and is easy to persist since they are costeffective and commonly homebound.As an important part of traditional Chinese exercise (TCE), Tai Chi is a type of mind-body practice that consists of a series of graceful, fl owing movements combined with deep diaphragmatic breathing, relaxation and meditation. (3) With a history of over 400 years, Tai Chi has evolved into various styles and schools that share some basic principles. (4) The non-competitive and self-paced features of Tai Chi make it a unique, feasible way for people to nurture physical and mental well-being. Rigorous and objective evidence supported the mental and physical effi cacy of Tai Chi for patients with lower limb OA. (5)(6)(7)(8) The physical component promotes muscular strength, proprioception, flexibility, postural control, and gait performance, and the mind component improves psychological health and life satisfaction.Application of biopsychosocial model continues to be known as a useful way to understand the physical impairments, psychological distress and social factors for management of OA. (9) According to the World Health Organisation's International Classification of Functioning, Disability, and Health (ICF), body functions, activity and participation are important components of health condition. (10) The ICF core sets for the component "body functions" in OA include a list of categories such as muscle power functions, joint functions, sensation of pain and sleep functions. (10) Even if the domain "infl ammation" is not ICF based, it plays a critical role in the pathophysiological process of OA. The aims of this review are to present a biopsychosocial framework summarizing the health benefi ts of Tai Chi in lower limb OA patients and trying to disentangle the mechanisms that potentially underlie these favourable effects.

show abstract

<p>High IL-6 level as a marker of lumbar osteoarthritis in patients older than 55 years with low back pain</p>

Cited by 4 publications

References 13 publications

PM2.5 facilitates IL‐6 production in human osteoarthritis synovial fibroblasts via ASK1 activation

PM2.5 facilitates IL‐6 production in human osteoarthritis synovial fibroblasts via ASK1 activation

Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

Beneficial Effects and Potential Mechanisms of Tai Chi on Lower Limb Osteoarthritis: A Biopsychosocial Perspective

Contact Info

Product

Resources

About