Outcome of bone recycling using liquid nitrogen as bone reconstruction procedure in malignant and recurrent benign aggressive bone tumour of distal tibia: A report of four cases

Gede, Eka Wiratnaya I; Ayu, Arrisna Artha Ida; Gn, Yudhi Setiawan I; Ign, Wien Aryana; Ketut, Suyasa I; Ketut, S.; Astawa, Putu

doi:10.1177/2309499017713940

Cited by 6 publications

(6 citation statements)

References 13 publications

(54 reference statements)

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“…Ten studies [3–[6], [15], [18], [19], [30], [32], [34]] of allograft reconstruction and 17 studies [[2], [4], [6], [11]–[17], [23], [26], [28], [30], [31], [33], [35]] of autograft reconstruction were included for comparative analysis. Among the 16 studies (165 cases), five [15–[17], [28], [33]] including 82 cases documented the use of recycled tumor-bearing bone. The mean followup durations were 68.5 (range, 8–288) and 67.5 (range, 6–288) months, respectively ( P = .899).…”

Section: Resultsmentioning

confidence: 99%

“…Is it necessary to perform ankle arthrodesis? In this systematic review, twenty-one studies [2], [3], [4], [5], [6], [11], [13], [14], [15], [16], [17], [19], [20], [21], [23], [25], [26], [30], [33], [34], [35] including 142 cases of ankle arthrodesis and six studies [3], [4], [15], [18], [28], [31], [32], [34] including 111 cases of ankle joint preservation were included for comparative analysis. Most researchers hold the notion that arthrodesis was the best way to provide excellent ankle stability, and the final functional outcome further confirmed this theory.…”

Section: Discussionmentioning

confidence: 99%

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Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome

Zhao

Yan

Guo

et al. 2019

Journal of Bone Oncology

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BackgroundPrimary malignant or aggressive benign bone tumors rarely occur in distal tibia, and limb salvage remains the mainstay of surgical options. However, reconstruction methods for large bone defect after wide tumor resection in this location are debatable. The purpose of this systematical review is to critically evaluate each reconstruction method regarding the postoperative complications and functional outcome.MethodsA systematic review of the 33 studies including 337 cases with tumors affecting distal tibia was performed after searching the PubMed and EMBASE databases. Pooled descriptive statistics with separate analyses for postoperative complications and functional outcome of different reconstruction options were performed.Results290 (86.1%) patients received limb salvage procedures. Reconstruction strategies including biological reconstruction, such as autograft, allograft, distraction osteogenesis and non-biological prosthetic replacement. The patients received limb salvage procedures tended to have a higher MSTS score (77.1% vs 70.9%, P = .055) and a higher incidence of local relapse (28/290 vs 0/47, P = .052) than those amputated. Biological reconstruction methods provided better functional outcome (78.4% vs 72.2%, P = .017) compared with non-biological prosthetic reconstruction, although similarity of incidence of major complications (51/253 vs 12/37, P = .091). With respect to the comparison between autograft and allograft reconstruction, the autograft seemed to have less major postoperative complications occurrence (27/165 vs 22/78, P = .032), and consequently better functional outcome (MSTS score, 80.2% vs 74.3%, P = .025) than allograft reconstruction.ConclusionsLimb salvage results in better functional outcome compared with amputation. Biological reconstruction is more advocated than prosthetics replacement, and furthermore, autograft might be suggested to be the optimal reconstructive method with regard to better postoperative functional outcome and less major complications.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome

Zhao

Yan

Guo

et al. 2019

Journal of Bone Oncology

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“…Liquid nitrogen can damage the osmolarity of cells by forming ice crystals which trigger apoptosis [11]. According to research by [12], bone recycling with liquid nitrogen for reconstruction after resection of malignant bone tumors offers many advantages. Of the 4 cases of bone recycling with liquid nitrogen, the average Musculoskeletal Tumor Society (MSTS) functional score was 75% without infection and local recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 4 cases of bone recycling with liquid nitrogen, the average Musculoskeletal Tumor Society (MSTS) functional score was 75% without infection and local recurrence. Reconstruction using liquid nitrogen provides good local control and functional results [12].…”

Section: Discussionmentioning

confidence: 99%

Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Arnaya

Suyasa

Wiratnaya

et al. 2023

EJMED

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Introduction: Malignant bone tumors have a global prevalence of 1% of the overall malignancy case, with a very low 5-year survival rate and high local recurrence. The limb-salvage surgery with bone recycling is widely developed in the management of malignant bone tumors. Hydrogen peroxide and liquid nitrogen are bone recycling mediator agents destroying the malignant tumor cells while preserving healthy bones as much as possible. The purpose of this study was to compare the effectiveness of hydrogen peroxide and liquid nitrogen with the number of tumor cell deaths using the Huvos score and BMP-2 expression in malignant bone tumors. Materials and Method: In vitro experimental research was performed on 30 core needle biopsy samples of bone malignant tumors divided into 2 groups of hydrogen peroxide and liquid nitrogen. The parameters measured are Huvos score and BMP-2 level. Results: Based on this study, the characteristics of malignant bone tumors were dominated by primary tumors (83.9%), in female patients (53.3%) with an average age of 30 years. Liquid nitrogen gave better results than hydrogen peroxide, marked by a lower Huvos score (average 12.13 vs. 18.87, p=0.033) and a higher BMP-2 (average 39.53 ± 26.59 vs. 63.87 ± 27.61, p=0.020). Conclusion: Liquid nitrogen is an effective bone recycling agent for the management of malignant bone tumors.

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“…24 In the past few decades, limb salvage surgery has evolved, 5,25 and good limb function has been reported after remodeling using both tumor-type joint replacement and liquid nitrogen treatment of the bone (95% MSTS score: ⩾good). 5,26,27 With tumor-type arthroplasty, revision surgery is usually needed for a long-term follow-up, especially if the patient is a child. 28 In this study, none of the patients who underwent arthroplasty required revision surgery.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of comprehensive treatment for primary osteosarcoma

et al. 2020

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Purpose: This study aimed to evaluate the clinical features and outcomes of osteosarcoma to identify prognostic factors and determine new strategies to improve overall survival. Patients and Methods: We retrospectively analyzed 12 cases of osteosarcoma treated at our hospital from 2012 to 2017. Tumor site, tissue type, stage, treatments, adverse effects, postoperative limb function, surgical margin, and final outcomes were evaluated. Results: All patients received chemotherapy, and 10 underwent wide resection. The Musculoskeletal Tumor Society scores were more than good in all cases, and the 3-year survival rate was 73.3%. Two patients are alive with disease, eight have remained disease-free, and two died of the disease. Three of the four recurrent cases involved the pelvis. Conclusion: The treatment of primary osteosarcoma with wide resection in our department, therefore, yielded favorable outcomes. However, improved treatment strategies are needed for pelvic and advanced cases.

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Outcome of bone recycling using liquid nitrogen as bone reconstruction procedure in malignant and recurrent benign aggressive bone tumour of distal tibia: A report of four cases

Cited by 6 publications

References 13 publications

Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome

Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome

Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen

Outcomes of comprehensive treatment for primary osteosarcoma

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