Recombinant platelet derived growth factor-BB and hyaluronic acid effect in rat osteoarthritis models

Abstract

Osteoarthritis (OA) arises from imbalance of cartilage metabolism between the synthesis and degradation of type II collagen by the chondrocyte. Collagen type II degradation is characterized by increase in the biomarker of Ctelopeptide fragment of type II collagen (CTX-II), while the anabolic process of cartilage is characterized by an increase in the biosynthesis of procollagen amino terminal N-propeptide type IIA (PIIANP). Platelet derived growth factor (PDGF) with Hyaluronic Acid (HA) as a potent growth factor can be used to stimulate the higher formation of chondrocyte and PIIANP levels and lower CTX-II levels in mouse knee osteoarthritis model.

Recombinant platelet‐derived growth factor‐BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivo

“…Therefore, preventing or curing OA by intervening in chondrocyte apoptosis would be a valid strategy to modulate cartilage degeneration. Wang et al and Ding et al found that inhibiting apoptosis could be a potential therapeutic strategy for OA treatment A previous report showed that intra‐articular injection of 10 ng/mL recombinant PDGF‐BB combined with hyaluronic acid could alleviate OA by promoting the anabolism of collagen II and inhibiting catabolism in rats 16 . Based on the above description, PDGF‐BB promotes proliferation 12 .…”

“…At present, the mainstream belief in the literature is that there is a correlation between the degree of cartilage damage and chondrocyte could be a potential therapeutic strategy for OA treatment A previous report showed that intra-articular injection of 10 ng/mL recombinant PDGF-BB combined with hyaluronic acid could alleviate OA by promoting the anabolism of collagen II and inhibiting catabolism in rats. 16 Based on the above description, PDGF-BB promotes proliferation. 12 We investigated whether PDGF-BB has an antiapoptotic effect in OA.…”

“…Moreover, PDGF‐BB was found to be an apoptosis inhibitor via the Erk1/2 and p38 pathways and exhibited cytoprotective effects 13‐15 . PDGF‐BB could suppress cartilage degradation and improve the anabolism of chondrocytes to alleviate OA in vivo 16,17 . Thus, PDGF‐BB could be a possible treatment for OA.…”

“…[13][14][15] PDGF-BB could suppress cartilage degradation and improve the anabolism of chondrocytes to alleviate OA in vivo. 16,17 Thus, PDGF-BB could be a possible treatment for OA.…”

Anti-Inflammatory and Chondroprotective Effects of Platelet-Derived Growth Factor-BB on Osteoarthritis Rat Models

“…Similarly, a subsequent study showed that PDGF-BB suppressed apoptosis by regulating NF-κB and PI3K/AKT pathway in IL-1β-induced human chondrocytes [10]. In 2019, an in vitro study used recombinant PDGF-BB and hyaluronic acid in combination as potent growth factors to stimulate the increased formation of chondrocytes [11]. Greene MA et al noted that targeting signaling proteins, such as JAK1/2, was a better therapeutic approach to restoring the balance in anabolic and catabolic activity in cartilage than targeting PI3K/AKT signaling [12].…”