<i>Objective:</i> To investigate the possible association between the codon 72 polymorphism (Pro72Arg, rs1042522) of the tumor suppressor gene <i>(TP53)</i> and the presence of coronary artery disease (CAD) in Chilean subjects. <i>Subjects and</i><i>Methods:</i> A total of 209 unrelated patients with a diagnosis of CAD confirmed by angiography (33–74 years old) and 216 healthy controls (30–68 years old) were included in this study. The Pro72Arg polymorphism of the <i>TP53</i> gene was evaluated by PCR-RFLP. <i>Results:</i> The genotype distribution for the Pro72Arg variant of the <i>TP53</i> gene in CAD patients (PP: n = 13, 6.2%; PR: n = 61, 29.4%; RR: n = 135, 64.6%) and controls (PP: n = 18, 8.3%; PR: n = 94, 43.5%; RR: n = 104, 48.1%) was significantly different (p = 0.003). Similarly, the allelic frequency was also different (p = 0.003). The odds ratio for CAD related to the 72Arg allele was 2.0 (95% CI = 1.33–2.90), confirming the presence of an association. <i>Conclusion:</i> These findings suggest that the Pro72Arg polymorphism of the <i>TP53</i> gene is associated with CAD in Chilean individuals.
ResumenIntroducción: Diferentes genes han sido implicados en la etiología de la enfermedad arterial coronaria, entre ellos, el gen TP53. Recientemente, el polimorfismo en el codon 72 (Pro72Arg, rs1042522)
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