2011
DOI: 10.1159/000321206
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<i>TP53</i> Codon 72 Polymorphism Is Associated with Coronary Artery Disease in Chilean Subjects

Abstract: <i>Objective:</i> To investigate the possible association between the codon 72 polymorphism (Pro72Arg, rs1042522) of the tumor suppressor gene <i>(TP53)</i> and the presence of coronary artery disease (CAD) in Chilean subjects. <i>Subjects and</i><i>Methods:</i> A total of 209 unrelated patients with a diagnosis of CAD confirmed by angiography (33–74 years old) and 216 healthy controls (30–68 years old) were included in this study. The Pro72Arg polymorphism of th… Show more

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Cited by 6 publications
(5 citation statements)
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“…Contrary with the current findings, Khan et al (35) reported Arg72 allele as a risk factor for CAD in South African (Indian ancestry) patients, but in line with the present study, the laboratory markers did not correlate with the genotypes. Similarly, the Arg72 variant has been associated with increased risk of CAD (OR=2.0) in Chilean patients (64). A study by Manfredi et al (33), in agreement with Alkhalaf et al (31) and Lagares et al (63), failed to establish any association between Arg72Pro SNP and CAD in Italian subjects, but identified a significant association between CAD and smoking, dyslipidemia, type 2 diabetes, hypertension and family history of the disease.…”
Section: Frequency N (%) -------------------------------------------mentioning
confidence: 73%
“…Contrary with the current findings, Khan et al (35) reported Arg72 allele as a risk factor for CAD in South African (Indian ancestry) patients, but in line with the present study, the laboratory markers did not correlate with the genotypes. Similarly, the Arg72 variant has been associated with increased risk of CAD (OR=2.0) in Chilean patients (64). A study by Manfredi et al (33), in agreement with Alkhalaf et al (31) and Lagares et al (63), failed to establish any association between Arg72Pro SNP and CAD in Italian subjects, but identified a significant association between CAD and smoking, dyslipidemia, type 2 diabetes, hypertension and family history of the disease.…”
Section: Frequency N (%) -------------------------------------------mentioning
confidence: 73%
“…The investigation of non-coding TP53 SNPs is also omitted in clinical case-control studies on CAD. On the other hand, several studies have indicated that the coding SNP at codon 72 can play an important role in CAD (6)(7)(8). In the context of myocardial infarction, Al-Tu'ma et al observed that the Pro72Arg polymorphism was associated with the risk of myocardial infarction in the Iraqi patients (9).…”
Section: Introductionmentioning
confidence: 99%
“…2 Mutant types of TP53 gene may induce dysfunction of p53 by inhibiting apoptosis and playing a role in the pathogenesis of atherosclerosis. 3,4…”
Section: Introductionmentioning
confidence: 99%
“…2 Mutant types of TP53 gene may induce dysfunction of p53 by inhibiting apoptosis and playing a role in the pathogenesis of atherosclerosis. 3,4 Atherosclerosis is the leading cause of coronary artery disease (CAD) events. A variety of genes may be involved in any stage of atherogenesis and in atherosclerosis progression as already documented in genome-wide association studies, 5 case control studies, [6][7][8] and animal studies.…”
Section: Introductionmentioning
confidence: 99%
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