Polymorphisms of the NOS3 gene in Southern Chilean subjects with coronary artery disease and controls

Jaramillo, Priscilla; Lanas, Cecilia; Lanas, Fernando; Salazar, Luis A.

doi:10.1016/j.cca.2009.11.018

Cited by 22 publications

(21 citation statements)

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“…Controls were mainly matched in terms of gender and age. Fourteen studies were hospital-based [16–18,20,21,25,28,37–40,42,43,45], and 20 were population-based [9,12–15,19,22,23,26,27,29–34,36,41,46,47]. Thirty studies were performed using <500 subjects in the case group [12–27,29,33–36,38–47] and 33 were conducted with <500 subjects in the control group [9,12–15,17–29,32,34–47].…”

Section: Resultsmentioning

confidence: 99%

“…Thirty studies were performed using <500 subjects in the case group [12–27,29,33–36,38–47] and 33 were conducted with <500 subjects in the control group [9,12–15,17–29,32,34–47]. Furthermore, there were 20 studies of CAD [9,18,20,22,23,25,29,30,32,34–40,42–44,46], four of CHD [17,26–28], three of acute myocardial infarction [15,19,45], six of myocardial infarction (MI) [12–14,16,31,41], and four of acute coronary syndrome [21,24,33,47]. …”

Section: Resultsmentioning

confidence: 99%

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Endothelial Nitric Oxide Synthase (eNOS) 4b/a Gene Polymorphisms and Coronary Artery Disease: Evidence from a Meta-Analysis

Yang

Liu

et al. 2014

IJMS

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A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a polymorphism. Case-control, cohort or cross-sectional studies evaluating the association between eNOS 4b/a polymorphism and CAD susceptibility were systematically identified in PubMed up to 31 October 2013. Pooled odds ratios (OR) and corresponding 95% confidence intervals (CIs) were calculated to assess the association in overall and subgroup analyses. A total of 10,617 cases and 8302 controls from 37 studies were included in the study. The results of overall analysis revealed significant positive associations between CAD risk and eNOS 4b/a polymorphism in homozygote comparisons (OR = 1.47, 95% CI = 1.16–1.87), heterozygote comparisons (OR = 1.14, 95% CI = 1.02–1.27) and dominant models (OR = 1.18, 95% CI = 1.06–1.33). In subgroup analyses, similar associations were identified in African individuals, as determined using population-based source subgroups and noted in small-and-moderate sample size subgroups (case sample size or control sample size <500). The current meta-analysis revealed that eNOS 4b/a polymorphisms could be a risk factor for developing CAD, particularly in African populations and population-based subgroups.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase (eNOS) 4b/a Gene Polymorphisms and Coronary Artery Disease: Evidence from a Meta-Analysis

Yang

Liu

et al. 2014

IJMS

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“…Similarly, Gluba et al (2009) found that in the young Polish population, the T786C polymorphism does not increase the risk of myocardial infarction. Jaramillo et al (2010), studying the T786C polymorphism in Chilean patients with a diagnosis of CAD found a higher frequency of the TT genotype and the distribution of that genotype was not significantly different between the individuals with CAD and control.…”

Section: Discussionmentioning

confidence: 99%

Research Article Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.

Barbosa¹,

Silva²,

Lagares³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large-and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has been shown to be a promising therapeutic agent against cardiovascular diseases. The eNOS gene assumes several important functions, including regulation of vascular tone and regional blood flow, the suppression of vascular smooth muscle cell proliferation, and modulation of leukocyte-endothelium interactions. The T786C polymorphism is an important point mutation, where thymine is changed to cytosine. T786C significantly reduces the activity of the eNOS promoter gene. Two hundred and ninety-seven peripheral blood samples were collected from patients with the previous diagnosis of atherosclerotic disease based on clinical examination and confirmed by imaging methods. Results were compared using the chisquare test and the G-test. In the present study, the TC genotype was more frequent in both case and control groups with no statistically significant difference. Comparing the relation TC/TT and CC genotypes in the case and control groups, there was no statistically significant difference. No significant difference was found when genotypes were analyzed regarding gender and smoking. Our results suggest a strong tendency of the T allele, in single or double dose, to be associated with atherosclerosis that was not confirmed by the scientific data.

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“…The eNOS gene presents a variable number of tandem repeat (27 bp) in intron 4, and the rare 4‐repeat allele was reported to be associated with coronary atherosclerosis and MI in several populations. However, these results are also conflicting (Gardemann et al ., ; Jemaa et al ., ; Jaramillo et al ., ). Other studies have reported that eNOS gene polymorphisms are associated with BD susceptibility in Italian, Korean and Turkish populations (Salvarani et al ., ; Kim et al ., ; Karasneh et al ., ).…”

Section: Introductionmentioning

confidence: 98%

Polymorphisms of the NOS3 gene in Tunisian patients with Behçet's disease

Kallel

Sbai

Houman

et al. 2015

Int J Immunogenetics

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Behçet's disease (BD) is a multisystem inflammatory disease characterized by recurrent orogenital ulceration, ocular inflammation and skin lesions. Reduced plasma nitric oxide (NO) levels in patients with BD have been implicated in the development of the endothelial abnormalities and thrombotic complications occurring in these patients. Polymorphisms in the endothelial nitric oxide synthase gene (NOS3) have been inconsistently associated with BD. This inconsistency may derive from population stratification secondary to ethnic diversity, and consideration limited to only one rather than combinations of polymorphisms. We studied three genetic variations in the NOS3 gene: a single nucleotide polymorphism in the promoter region -786T>C, in exon 7 (Glu298Asp), and a variable number of tandem repeats in intron 4 (4a4b) of the NOS3 gene in 100 unrelated Tunisian patients with BD and 148 healthy controls. In addition, we also examined the association of NOS3 gene haplotypes with BD. Analyses of the Glu298Asp, -786T>C and 4a4b polymorphisms were made by the polymerase chain reaction (PCR) restriction fragment length polymorphism technique and PCR genotyping, respectively. The distribution of the Glu298Asp genotype differed significantly between patients with BD and controls (P = 0.01). Allele Asp298 was significantly more frequent in patients with BD than in controls (P = 0.005, OR = 1.70, 95% CI 1.14-2.54). In contrast, distribution of alleles and genotypes of -786T>C and 4a4b polymorphisms was not different between the control and BD group. However, the frequency of Asp-T-4b haplotype was significantly higher in patients with BD than in healthy controls. By gender, the signification remained only for heterozygous men (P = 0.03) and homozygous women (P = 0.02). These results suggest that Glu298Asp polymorphism of the NOS3 gene is associated with BD susceptibility in Tunisian patients.

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Polymorphisms of the NOS3 gene in Southern Chilean subjects with coronary artery disease and controls

Cited by 22 publications

References 50 publications

Endothelial Nitric Oxide Synthase (eNOS) 4b/a Gene Polymorphisms and Coronary Artery Disease: Evidence from a Meta-Analysis

Endothelial Nitric Oxide Synthase (eNOS) 4b/a Gene Polymorphisms and Coronary Artery Disease: Evidence from a Meta-Analysis

Research Article Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.

Polymorphisms of the NOS3 gene in Tunisian patients with Behçet's disease

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