Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls

Jaramillo, Priscilla; Mora, Muñoz; Lanas, M Cecilia; Lanas, Z Fernando; Salazar, Luis A.

doi:10.1016/j.cca.2006.02.030

Cited by 50 publications

(33 citation statements)

References 50 publications

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“…A total of 18 studies were conducted in the Asian population (7,16,20,21,23,25,26,(33)(34)(35)(36)(37)41,42,45,48,51,52) and 21 in the non-Asian population (17-19,22,24,27-32,38-40, 43,44,46,47,49-50). In terms of the source of the controls, 15 were from hosptial-based (HB) studies (16,17,20,24,25,28,30,34,35,37,41,43,45,47,51) and 24 were from population-based (PB) studies (7,18,19,(21)(22)(23)26,27,29,(31)(32)(33)36,(38)(39)…”

Section: Study Characteristicsmentioning

confidence: 99%

Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta-analysis of 39 case-control studies

Gao

Zeng

Wang

et al. 2013

Molecular Medicine Reports

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Abstract. Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent. The present meta-analysis aimed to evaluate the precise result by searching the PubMed database and using 39 case-control studies comprising 7489 cases and 7051 controls.Each study tested the association between the eNOS Glu298Asp polymorphism and CHD. A meta-analysis was then conducted using the Comprehensive Meta Analysis 2.2 software to calculate the pooled odds ratios (ORs) of five genetic models with 95% confidence intervals (CIs). Publication bias was also explored. The meta-analysis showed a significant association between the eNOS Glu298Asp polymorphism and CHD susceptibility for all the genetic models [Asp vs. Glu, OR 1.26, 95% CI 1.14-1.40, P<0.001; Asp/Asp vs. Glu/Glu, OR 1.58, 95% CI 1.23-2.02, P<0.001; Glu/Asp vs. Glu/Glu, OR 1.12, 95% CI 1.03-1.22, P=0.001; (Glu/Asp+Asp/Asp) vs. Glu/ Glu, OR 1.17, 95% CI 1.07-1.27, P<0.001; Asp/Asp vs. (Glu/ Glu+Glu/Asp), OR 1.59, 95% CI 1.25-2.03, P<0.001]. Subgroup and sensitivity analyses indicated that the result was robust. A weak publication bias was detected. The results indicated that the eNOS Glu298Asp polymorphism is a risk factor for developing CHD, particularly in the Asian population.

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Section: Study Characteristicsmentioning

confidence: 99%

Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta-analysis of 39 case-control studies

Gao

Zeng

Wang

et al. 2013

Molecular Medicine Reports

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“…The reduced endothelial production of NO in the coronary arteries would predispose carriers of the C allele to coronary spasm. The coronary spasm might be more severe and prolonged in CC homozygotes, increasing the risk of CAD (Jaramillo et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

T-786C single-nucleotide polymorphism (SNP) of endothelial nitric oxide synthase gene and serum level of vascular endothelial relaxant factor (VERF) in non-diabetic patients with coronary artery disease

A¹,

F²

2012

Afr. J. Biotechnol.

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Various mutations on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, a vascular endothelial relaxant factor (VERF), and may accelerate the process of atherosclerosis. The study was designed to investigate the frequency of T-786C polymorphism of the gene in patients suffering from coronary artery disease (CAD) in North West of Iran. One hundred and twenty (120) subjects including 60 patients with angiographically diagnosed CAD and 60 age and sex matched CAD-free subjects as control were studied. The levels of nitric oxide in the samples were measured with the Griess Method. The genotype studies were carried using allele specific PCR. Compared with the control, reduced levels of NO were noticed in the patient group (p < 0.05) and significantly high frequency of eNOs -786C genotype was found in CAD patients (p < 0.05). The low levels of NO and increased frequency of T-786C polymorphism might be a risk factor in the progression of coronary artery disease in the studied subjects.

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“…Los niveles séricos de glucosa, acido úrico, triglicéridos, colesterol total y colesterol HDL fueron determinados mediante métodos enzimático-colorimétricos 20 . El colesterol de las lipoproteínas de baja densidad (LDL-C) fue calculado usando la formula de Friedewald cuando la concentración de triglicéridos no excedió los 400 mg/dL.…”

Section: Determinaciones Bioquímicasunclassified

“…Sin embargo, la información en relación a las bases genéticas de EAC en nuestro país es insuficiente [20][21][22] . Así, el objetivo del presente estudio fue evaluar la posible asociación entre el polimorfismo Pro72Arg del gen TP53 y EAC en individuos chilenos.…”

Section: Introductionunclassified

Polimorfismo Pro72Arg del gen TP53 se asocia a enfermedad coronaria en individuos Chilenos

L¹,

Saavedra

Jaramillo

et al. 2009

Rev Chil Cardiol

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Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls

Cited by 50 publications

References 50 publications

Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta-analysis of 39 case-control studies

Association between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: A meta-analysis of 39 case-control studies

T-786C single-nucleotide polymorphism (SNP) of endothelial nitric oxide synthase gene and serum level of vascular endothelial relaxant factor (VERF) in non-diabetic patients with coronary artery disease

Polimorfismo Pro72Arg del gen TP53 se asocia a enfermedad coronaria en individuos Chilenos

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