−786T&gt;C polymorphism of the endothelial nitric oxide synthase gene in Chilean subjects with coronary artery disease and controls

Jaramillo, Priscilla; Lanas, Cecilia; Lanas, Fernando; Salazar, Luis A.

doi:10.1016/j.cca.2007.09.011

Cited by 19 publications

(5 citation statements)

References 29 publications

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“…Findings of Salimi et al are concurrent with the present findings, wherein the frequency of the C allele in individuals with T786C polymorphism is higher in coronary artery disease patients than in controls (22). On the contrary, Jaramillo et al suggested that eNOS T786C was not associated with coronary artery disease in Chilean individuals (23). Reduced NO production is associated with vascular dysfunction and smooth muscle cell proliferation in the arterial endothelium, thereby resulting in the pathogenesis of atherosclerosis (24).…”

Section: Discussionsupporting

confidence: 87%

Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke

Çilingir¹,

Dönder²,

Milanlıoğlu³

et al. 2019

Eastern J Med

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Endothelial nitric oxide synthase (eNOS) gene polymorphisms are suspected to increase the risk of ischaemic stroke (IS). eNOS-synthesized NO regulates vascular tone and inhibits the progression of atherosclero sis. The present study aimed to determine the association between eNOS polymorphisms G894T and T786C and IS. Sixty acute IS patients (32 male, 28 female) were included and classified in accordance with the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Genotypes of patients with eNOS G894T and eNOS T786C polymorphisms were determined through polymerase chain reaction. Significant differences were observed in the distribution of eNOS T786C polymorphism among IS subgroups. The eNOS T786C polymorphism heterozygote (TC) and homozygote (CC) genotypes more frequent in patients in the large artery atherosclerosis (LAA) subgroup. Considering a dominant model of inheritance for eNOS T786C polymorphism, the risk of IS was higher for the LAA subgroup than for other IS subgroups. Among potential haplotypes, the eNOS 786C+ eNOS 894G haplotype was associated with an increased risk of LAA; however, this finding was not statistically significant. eNOS gene polymorphisms are suspected to increase the risk of ischaemic stroke. Our results suggest that the eNOS T786C gene polymorphism is associated with LAA in IS patients.

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Section: Discussionsupporting

confidence: 87%

Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke

Çilingir¹,

Dönder²,

Milanlıoğlu³

et al. 2019

Eastern J Med

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“…A link between the CC genotype of this polymorphism and CAD has been found in independent studies including those in Chinese and Korean populations ( Jia et al, 2007;Kim et al, 2007). Nevertheless, À786 T=C polymorphism of the eNOS gene was not associated with CAD in the study of Chilean patients and healthy controls ( Jaramillo et al, 2008). In Turkish individuals, this variation might be a risk factor for CAD according to Tangurek et al (2006).…”

Section: Discussionmentioning

confidence: 93%

Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

Alp

Menevşe

Tulmaç³

et al. 2009

DNA and Cell Biology

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Polymorphic variants of genes encoding proteins involved in vascular remodeling may genetically diverge among different populations and play a role in the susceptibility to the coronary artery disease (CAD). MMP-9-1562 C/T (rs3918242), eNOS T-786C (rs2070744), and Glu298Asp (rs1799983) are among the most studied of these polymorphisms. The aim of this study was to determine the relationship between CAD and these polymorphisms in the Turkish population. The analysis included 146 CAD+ and 122 CAD- individuals. Genomic DNA was isolated from whole blood and genotyping was performed by the PCR-RFLP method. No significant associations were found between -1562 C/T (p = 0.557), Glu298Asp (p = 0.432), and -786 T/C (p = 0.055) polymorphisms and CAD. The distribution of each haplotype also did not differ between CAD+ and the CAD- samples (p > 0.05). The present investigation is the first to study an association between -1562 C/T polymorphism and CAD in the Turkish population. In conclusion, no appreciable differences between CAD+ and CAD- samples were found in terms of polymorphisms mentioned above.

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“…Similarly, Jaramillo et al and Alp et al observed that T-786C polymorphism of the eNOS gene was not associated with CAD in a studied sample of Chilean and Turkish individuals, respectively (19,20). To our knowledge, no parallel investigations were performed on Egyptian population regarding the association of T-786C polymorphism of eNOS with the incidence of CAD.…”

Section: Discussionmentioning

confidence: 78%

T-786C variation in the promoter sequence of human <i>eNOS</i> gene markedly influences its expression level

Elakkad

Abou-Aisha

Hassanein

2017

DD&T

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−786T>C polymorphism of the endothelial nitric oxide synthase gene in Chilean subjects with coronary artery disease and controls

Cited by 19 publications

References 29 publications

Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke

Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke

Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

T-786C variation in the promoter sequence of human <i>eNOS</i> gene markedly influences its expression level

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