the concentration of its active ingredients, physical, chemical, phytochemical and in vitro, in vivo parameters [2]. Triphala (Sanskrit; tri = three and phala = fruits) is a wellrecognized and revered polyherbal medicine consisting of dried fruits of the three plant species Emblica officinalis (Family Euphorbiaceae), Terminalia bellerica(Family Combretaceae), and Terminalia chebula (Family Combretaceae) that are native to the Indian subcontinent. It is classified as a tridoshic rasayana in Ayurvedic medicine as it promotes longevity and rejuvenation in patients of all constitutions and ages. The formula consists of the fruits Amalaki or the Indian Gooseberry, Bibhitaki, and Haritaki of
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The pharmaceutical industry is a vital component of health-care systems all over the world engaged in discovery, development, manufacture, and marketing of medicines for human as well as animal health. Pharmaceutical industries also have many environmental problems, like the other chemical industries. The pharmaceutical industry is based primarily on the scientific formulation, research, and development of drugs, that is, helpful in the prevention or treatment of diseases and disorders. The manufacturing of APIs and formulation processes involves the use of various chemicals which includes various corrosive and irritant agents such as acids, bases, oxidizing and reducing agents, solvents, and many more which can be found sometimes at very high concentrations and are hazardous to health of persons performing the various processes during manufacturing and formulation of API and medicines. The effective management of the chemical risks linked to the handling of these agents is mandatory for the safety of the workers in the industry, ethically and also legally as per the rules and guidelines of various acts regulating the functioning of the pharma industry. This article provides a comprehensive review of various chemical hazards generally encountered by the pharmaceutical industry, its management and regulation in India.
Auditing is a vital function within a pharmaceutical company nowadays. Quality audit is a review and evaluation of all or part of a quality system with the specific purpose of improving it. It is one of the means to examine pharmacy programs and ensures that the procedures and reimbursement mechanisms comply with the contractual and regulatory requirements. A quality audit is usually conducted by external or independent experts or by a team designated by management for this purpose. These audits can be extended to suppliers and contractors as well. An audit will assess the strengths and weaknesses of quality assurance and quality assurance processes, the results of which assists in improving processes and building a better system for company benefits. This article focuses on various aspects of quality auditing in the pharmaceutical industry including its principles, objectives, importance and benefits and planning along with the deficiencies that are likely to occur during the process. This review comprises a well-organized summary of various guidelines available till date using the Google Scholar search engine and the keywords listed below.
Herbs are an effective source of Ayurvedic medicine and other traditional medicines as well as modern medicine. Faced with the challenges of modern medicine, the world is shifting toward Ayurvedic theories of health management. In the treatment of the disease, the use of drugs is not limited. This increases the demand for raw materials exponentially. However, production growth is still linear. Rapid depletion of resources creates major problems. To fill the deficit, advances in adulteration and substitution are becoming more prevalent. This adulteration and substitution are a burning problem in an industry that threatens the integrity of Ayurvedic system of medicine. Imprecise knowledge, misidentification, deforestation, and personal gain have led to adulteration. Therefore, an understanding of all ways of adulteration and substitutions is needed to amend this illegal act and maximize consumer safety. This article focuses on adulteration, its types and various methods of adulteration, as well as the concept of substitution, reasoning, and its types. Attempts have also been made to differentiate these two related terms.
Clothing and textile industry are one among the biggest contributors of the landfills affecting the world’s environment. This industry is ranked third in contaminating the globe, after oil and agriculture industry. Various reasons involved for this, would be excessive demand and supply of cheap clothing (fast fashion) which leads to more waste. The customers are unware of what they buy? The consumers should first understand fashion- “Fashion is what we require or feel every day, it includes creativity, mood, tradition and lifestyle”. Today fashion industry is huge in terms of global business contribution. In spite of its popularity, as other businesses it also has gloomy character involved, where pressure is to reduce cost, fast fashion, toxic chemicals and dyes used, misuse the labor efforts, textile waste and over consumption of energy. This study analyses how we can reduce textile waste, water and energy by using Dry-Dye method on Recycled polyester derived from PET bottles. The basis of the research is to convey attention to the Modest Fashion customers as the material created by these innovations best suits their necessity, remembering their wellbeing and advantages to the worldwide condition.
YogarajGugguluvati is one of the most commonly used polyherbal formulation in Ayurvedic clinical practice since ages for the ailments of various bone disorders.Objective: The present work was carried out in order to evaluate comparatively three different and popular formulations of YogarajGugguluVati to confirm their quality and also to highlight the variations that may be present in them.Methods: Comparative assessment of three different and popular marketed formulations of YogarajGugguluVati was carried out for their organoleptic, pharmaceutical, physicochemical and phytochemical properties as per the methods prescribed in Pharmacopoeias. Results:The observations reveal that all the parameters of three brands of YogarajGugguluVati had considerable differences in their values. The value of water soluble and alcohol soluble extractives of Brand A was very much higher and lesser than the standard values respectively. The pH of all the tablets was also higher than that of the standard values. The Hardness and Disintegration time of the tablets of Brand B was also very high than the other two brands. The tablets of Brand A also failed the weight variation test. Conclusion:It can be concluded from the overall results that phytochemical and analytical evaluation and standardization of all the formulations should be performed strictly on all formulations so as to optimize the final product according to the standards, which would otherwise affect the therapeutic activity of the product.
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