the concentration of its active ingredients, physical, chemical, phytochemical and in vitro, in vivo parameters [2]. Triphala (Sanskrit; tri = three and phala = fruits) is a wellrecognized and revered polyherbal medicine consisting of dried fruits of the three plant species Emblica officinalis (Family Euphorbiaceae), Terminalia bellerica(Family Combretaceae), and Terminalia chebula (Family Combretaceae) that are native to the Indian subcontinent. It is classified as a tridoshic rasayana in Ayurvedic medicine as it promotes longevity and rejuvenation in patients of all constitutions and ages. The formula consists of the fruits Amalaki or the Indian Gooseberry, Bibhitaki, and Haritaki of
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The pharmaceutical industry is a vital component of health-care systems all over the world engaged in discovery, development, manufacture, and marketing of medicines for human as well as animal health. Pharmaceutical industries also have many environmental problems, like the other chemical industries. The pharmaceutical industry is based primarily on the scientific formulation, research, and development of drugs, that is, helpful in the prevention or treatment of diseases and disorders. The manufacturing of APIs and formulation processes involves the use of various chemicals which includes various corrosive and irritant agents such as acids, bases, oxidizing and reducing agents, solvents, and many more which can be found sometimes at very high concentrations and are hazardous to health of persons performing the various processes during manufacturing and formulation of API and medicines. The effective management of the chemical risks linked to the handling of these agents is mandatory for the safety of the workers in the industry, ethically and also legally as per the rules and guidelines of various acts regulating the functioning of the pharma industry. This article provides a comprehensive review of various chemical hazards generally encountered by the pharmaceutical industry, its management and regulation in India.
Auditing is a vital function within a pharmaceutical company nowadays. Quality audit is a review and evaluation of all or part of a quality system with the specific purpose of improving it. It is one of the means to examine pharmacy programs and ensures that the procedures and reimbursement mechanisms comply with the contractual and regulatory requirements. A quality audit is usually conducted by external or independent experts or by a team designated by management for this purpose. These audits can be extended to suppliers and contractors as well. An audit will assess the strengths and weaknesses of quality assurance and quality assurance processes, the results of which assists in improving processes and building a better system for company benefits. This article focuses on various aspects of quality auditing in the pharmaceutical industry including its principles, objectives, importance and benefits and planning along with the deficiencies that are likely to occur during the process. This review comprises a well-organized summary of various guidelines available till date using the Google Scholar search engine and the keywords listed below.
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