Chemical Hazards in Pharmaceutical Industry: An Overview

Abstract

The pharmaceutical industry is a vital component of health-care systems all over the world engaged in discovery, development, manufacture, and marketing of medicines for human as well as animal health. Pharmaceutical industries also have many environmental problems, like the other chemical industries. The pharmaceutical industry is based primarily on the scientific formulation, research, and development of drugs, that is, helpful in the prevention or treatment of diseases and disorders. The manufacturing of APIs and formulation processes involves the use of various chemicals which includes various corrosive and irritant agents such as acids, bases, oxidizing and reducing agents, solvents, and many more which can be found sometimes at very high concentrations and are hazardous to health of persons performing the various processes during manufacturing and formulation of API and medicines. The effective management of the chemical risks linked to the handling of these agents is mandatory for the safety of the workers in the industry, ethically and also legally as per the rules and guidelines of various acts regulating the functioning of the pharma industry. This article provides a comprehensive review of various chemical hazards generally encountered by the pharmaceutical industry, its management and regulation in India.

Unveiling the potential of deep eutectic solvents to improve the conformational and colloidal stability of immunoglobulin G antibodies

“…8 Despite the clinical relevance of the excipients, recent studies have shown that some of these excipients are not environmentally friendly. 10,11…”

“…8 Despite the clinical relevance of the excipients, recent studies have shown that some of these excipients are not environmentally friendly. 10,11 Several research groups have shown the impact of the toxic solvent systems used in pharmaceutical industries. 10,11 In particular, in protein stability studies, it has been reported that solvents not only interact with the structure of proteins but also play a dominant role in their toxicity profile.…”

“…10,11 Several research groups have shown the impact of the toxic solvent systems used in pharmaceutical industries. 10,11 In particular, in protein stability studies, it has been reported that solvents not only interact with the structure of proteins but also play a dominant role in their toxicity profile. 12,13 Thus, there is a critical need to find biocompatible excipients or solvents that could help in maintaining the structure of proteins, and in particular the IgG protein.…”

Application of Feature Extraction Methods for Chemical Risk Classification in the Pharmaceutical Industry

“…The diversity and combinations of these substances is so great that it is impossible to list them all. Quite a big problem are fillers, i.e., inert agents aimed at improving the appearance, durability or supporting the solubility of the finished product [ 14 ]. Fillers pose a serious risk of poisoning workers, and the properties of these agents can lead to ignition or explosion.…”

“…The frequency and effects of chemical hazards have increased significantly in recent years, which is also due to the development of the chemical industry. By industrial hazard, we mean a condition that causes human injury, disease or death [ 14 ]. There are hazards in the production of drugs with the following substances and mixtures: With explosive properties; With oxidizing properties; Extremely flammable; Highly flammable; Very toxic; Harmful; Corrosive, irritating item; Sensitizing; Mutagenic; Toxic for reproduction; Dangerous for the environment [ 15 ].…”