Evaluation of Quality Parameters of Three Different Marketed Brands of Yogaraj gugguluvati: A Polyherbal Formulation

Abstract

YogarajGugguluvati is one of the most commonly used polyherbal formulation in Ayurvedic clinical practice since ages for the ailments of various bone disorders.Objective: The present work was carried out in order to evaluate comparatively three different and popular formulations of YogarajGugguluVati to confirm their quality and also to highlight the variations that may be present in them.Methods: Comparative assessment of three different and popular marketed formulations of YogarajGugguluVati was carried out for their organoleptic, pharmaceutical, physicochemical and phytochemical properties as per the methods prescribed in Pharmacopoeias. Results:The observations reveal that all the parameters of three brands of YogarajGugguluVati had considerable differences in their values. The value of water soluble and alcohol soluble extractives of Brand A was very much higher and lesser than the standard values respectively. The pH of all the tablets was also higher than that of the standard values. The Hardness and Disintegration time of the tablets of Brand B was also very high than the other two brands. The tablets of Brand A also failed the weight variation test. Conclusion:It can be concluded from the overall results that phytochemical and analytical evaluation and standardization of all the formulations should be performed strictly on all formulations so as to optimize the final product according to the standards, which would otherwise affect the therapeutic activity of the product.

Determination of microbial load, total Phenolic and flavonoids contents in polyherbal formulation “yograj guggulu vati”

“…Guggulu is the principal ingredient of Yogaraja guggulu formulations. It is also the principal ingredient of several formulations such as Rasnadi guggulu, Vatari guggulu and Vayusadi guggulu etc are traditionally used for musculoskeletal problems, body pain, osteoarthritis, obesity, sciatica and rheumatoid arthritis etc 2 . The preparation of yogaraja guggulu vati (YGV) is based on traditional method mentioned in the Ayurvedic Pharmacopoeia of India.…”

“…It is prepared from 28 ingredients and it is shown in table 1. It has been investigated that YGV has good quality, strength and purity 2 . Agarwal et al 2018 investigated that YGV did not contain heavy metals (Lead and Cadmium) more than prescribed limits.…”

“…It has been investigated that YGV has good quality, strength and purity 2 . Agarwal et al 2018 investigated that YGV did not contain heavy metals (Lead and Cadmium) more than prescribed limits. Phenolic and flavonoids compound of the polyherbal formulations and crude drug are important to justify its acceptability in the modern system of medicine.…”