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Electrolyte-gated organic field-effect transistors are successfully used as biosensors to detect binding events occurring at distances from the transistor electronic channel that are much larger than the Debye length in highly concentrated solutions. The sensing mechanism is mainly capacitive and is due to the formation of Donnan's equilibria within the protein layer, leading to an extra capacitance (CDON) in series to the gating system.

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Anchored, biotinylated phospholipids forming the capturing layers in an electrolyte-gated organic field-effect transistor (EGOFET) allow label-free electronic specific detection at a concentration level of 10 nM in a high ionic strength solution. The sensing mechanism is based on a clear capacitive effect across the PL layers involving the charges of the target molecules.

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Summary: Mixtures of diethyl glycol dimethyl ether vapors and argon were used to feed RF (13.56 MHz) glow discharges and coat polystyrene substrates with poly(ethylene oxide) (PEO)‐like thin films. Different power input values have been used to obtain coatings with different cell‐adhesive properties. Cell‐culture experiments showed a tight correlation between the adhesion/morphology of cultured cell‐lines and the chemical composition of the coatings; the ability of PEO‐like coatings to discourage or promote cell adhesion could thus easily be related to the power delivered to the plasma. Combined deposition processes of different PEO‐like coatings have been performed, with the method of physical masking, to produce surfaces micro‐patterned with cell‐adhesive tracks alternating with cell‐repulsive domains. The micro‐arrangement of different cell‐adhesive domains enabled the patterning of cell cultures and induced the alignment of cells along predefined directions.