Homogeneous and Micro‐Patterned Plasma‐Deposited PEO‐Like Coatings for Biomedical Surfaces

Sardella, Eloisa; Gristina, Roberto; Senesi, Giorgio S.; d’Agostino, Riccardo; Favia, Pietro

doi:10.1002/ppap.200400013

Cited by 102 publications

(140 citation statements)

References 31 publications

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“…9͒, denotes for the PEO "part" ͑the "shell"͒ of the micelles. [76][77][78] In other words, the shape of the C1s spectrum for specimens CN and CNC, including the characteristic binding energies ͑Table IV͒ and surface and shape of the peaks at about 286.5 eV ͑Figs. 9 and 10͒, proves the presence of micelles ͑6% for specimen CN and 4% for specimen CNC͒ in the …”

Section: C81mentioning

confidence: 99%

Corrosion Performance of Carbon Steel in Simulated Pore Solution in the Presence of Micelles

Koleva

Wit

et al. 2011

J. Electrochem. Soc.

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This study presents the results on the investigation of the corrosion behavior of carbon steel in model alkaline medium in the presence of very low concentration of polymeric nanoaggregates ͓0.0024 wt % polyethylene oxide ͑PEO͒ 113 -b-PS 70 micelles͔. The steel electrodes were investigated in chloride-free and chloride-containing cement extracts. The electrochemical measurements ͑electrochemical impedance spectroscopy and potentiodynamic polarization͒ indicate that the presence of micelles alters the composition of the surface layers ͑i.e., micelles were indeed absorbed to the steel surface͒ and influences the electrochemical behavior of the steel, i.e., the micelles lead to an initially increased corrosion resistance of the steel whereas no significant improvement was observed within longer immersion periods. Surface analysis, performed by environmental scanning electronic microscopy, energy-dispersive x-ray analysis, and x-ray photoelectron spectroscopy, supports and elucidates the corrosion performance. The product layers in the micelles-containing specimens are more homogenous and compact, presenting protective ␣-Fe 2 O 3 and/or Fe 3 O 4 , whereas the product layers in the micelles-free specimens exhibit mainly FeOOH, FeO, and FeCO 3 , which are prone to chloride attack. Therefore, the increased "barrier effects" along with the layers composition and altered surface morphology denote for the initially increased corrosion resistance of the steel in chloride-containing alkaline medium in the presence of micelles. A well-known fact is that corrosion of steel reinforcement can cause reinforced concrete deterioration and thus affect civil structures durability.1,2 Logically, corrosion-related issues result in a significant economic loss. For example, in the United States, the annual direct cost of bridge infrastructure corrosion was estimated to be $8.3 billion, and the indirect cost was reported to be many times higher. 3In normal conditions, the reinforcing steel embedded in cementbased materials ͑i.e., cement paste, mortar, and concrete͒ is in a passive state because of the high alkalinity ͑pH = 12.6-13.5͒ of the pore solution and the cement paste, respectively. 4,5 However, corrosion can be initiated due to carbonation or chloride contamination. 6 Carbonation can result in a pH drop ͑to about 8-9͒ 7,8 in the pore solution of the bulk cementitious matrix, leading to a general corrosion of the reinforcing steel. In the event of chloride penetration and chloride arrival at the steel/cement paste interface, localized corrosion is initiated; the local pH can drop to even below 6, resulting in fast corrosion propagation. This will cause accelerated damage of the reinforcing steel and possible rapid failure of reinforced concrete. 9To minimize the corrosion processes, various methods and techniques are used. Among them, the polymer-based organic corrosion inhibitors are widely applied because they can provide an easy handling, cost-effective corrosion prevention, delaying corrosion initiation.10-14 The organic inh...

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Section: C81mentioning

confidence: 99%

Corrosion Performance of Carbon Steel in Simulated Pore Solution in the Presence of Micelles

Koleva

Wit

et al. 2011

J. Electrochem. Soc.

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“…The variety of easily accessible and relatively cheap low molecular weight monomers combined with a simple chemical structure make them ideal for plasma polymerisation and surface analysis. A good control of the plasma parameters is essential, as a (partial) loss of the PEO repeating unit drastically lowers the non-fouling behaviour of the coating [69]. The second group of monomers is the fluorocarbon family.…”

Section: Alternating Cell-adhesive and Cell-repulsive Microstructuresmentioning

confidence: 99%

Non-thermal plasma assisted lithography for biomedical applications: an overview

Cools

Morent

2016

IJNT

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Plasma assisted surface patterning is becoming a well-established technique that introduces both alternating surface texture and chemistry on substrates for biomedical applications. This review consists of an overview on the developments in this field over the last 15 years. Special attention is given to the different kinds of chemistry that can be introduced and their effect on the surface-cell interaction, as well as their feasibility for possible applications in the field of regenerative medicine.

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“…The DEGDME solution was also allowed to react for 60 min before being rinsed by 50 µl PBS twice and dried with nitrogen. For deposition of dry DEGDME by PECVD, the open PMMA flow-cell was subjected to plasma cleaning and activation in an argon plus oxygen mixed plasma, with a flow rate of 100 standard cubic centimetre per minute (sccm) of argon and oxygen, for 1 min at 100 W and then the DEGDME deposition was carried out by sequential deposition of tetraethylorthosilicate (TEOS) and diethylene glycol dimethyl ether (DEGDME) by low pressure Plasma Enhanced Chemical Vapor Deposition (PECVD) [31][32][33]. The flow of TEOS and DEGDME were controlled using needle valve and the deposition was carried out in an argon plasma.…”

Section: Deposition Of Blocking Agents Into Pmma Microfluidic Flow-cellsmentioning

confidence: 99%

Evaluation of Different Nonspecific Binding Blocking Agents Deposited Inside Poly(methyl methacrylate) Microfluidic Flow-Cells

Gubala

Gandhiraman

et al. 2011

Langmuir

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Poly(methyl methacrylate) (PMMA) flow-cells containing microwells were deposited with different nonspecific binding blocking agents namely bovine serum albumin (BSA), cationic lipid (DOTAP) and diethylene glycol dimethyl ether (DEGDME). Water contact angle (WCA) and atomic force microscope (AFM) measurements were carried out to confirm the successful depositions of BSA, DOTAP, DEGDME onto the PMMA surfaces. Fluorescent intensity measurements were performed to evaluate the degree of non-specific adsorption of Cy5-labeled anti-IgG proteins onto plain and oxygen plasma treated (PT) PMMA flow-cells as well as PMMA flow-cells deposited with different above-mentioned blocking agents. We then employed a label-free detection method called total internal reflection ellipsometry (TIRE) to evaluate the stability of the deposited blocking agents inside the PMMA flow-cells. It was found that while DOTAP was the best agent for blocking the non-specific adsorption, it could be removed from the PMMA surfaces of the flow-cells upon rinsing with phosphate buffer saline (PBS) and later deposited back onto the Au-coated glass sensing substrate of the TIRE. The removal of the blocking agents from PMMA surfaces and their deposition onto the sensing substrate were further manifested by measuring the kinetics and the amount of adsorbed anti-a-hCG proteins. Overall, the dry DEGDME coating by plasma enhanced chemical vapor deposition (PECVD) showed very good blocking and excellent stability for subsequent assay inside the microwells. Our results could be useful when one considers what blocking agents should be used for PMMA-based microfluidic immunosensor or biosensor devices by looking at both the blocking efficiency and the stability of the blocking agent.

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Homogeneous and Micro‐Patterned Plasma‐Deposited PEO‐Like Coatings for Biomedical Surfaces

Cited by 102 publications

References 31 publications

Corrosion Performance of Carbon Steel in Simulated Pore Solution in the Presence of Micelles

Corrosion Performance of Carbon Steel in Simulated Pore Solution in the Presence of Micelles

Non-thermal plasma assisted lithography for biomedical applications: an overview

Evaluation of Different Nonspecific Binding Blocking Agents Deposited Inside Poly(methyl methacrylate) Microfluidic Flow-Cells

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