Plasma treatments and plasma deposition of polymers for biomedical applications

Favia, Pietro; d’Agostino, Riccardo

doi:10.1016/s0257-8972(97)00285-5

Cited by 271 publications

(160 citation statements)

References 30 publications

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“…There are different views on how surface treatment should be performed. For example, Favia and d'Agostino suggest that PSM technologies should be grouped into three categories [14]: (1) plasma enhanced chemical vapor deposition (PECVD), (2) plasma treatment and (3) plasma etching. Szabo et al [63], on the other hand, proposes that surface modification methods should be split into three general techniques: adding materials, removing materials, and changing materials.…”

Section: Physicochemical Plasma Treatmentmentioning

confidence: 99%

“…Orthopedic hip and dental implants need bone adhesion control on the Ti alloy surface by Ca þ ion implantation, and artificial blood vessels require endothelial cell adhesion control on polymeric surface by ion implantation for non-thrombogenicity [13]. Table 1 lists some of the more common research areas and applications of plasma treatment in biomaterials [14] and Table 2 shows the advantages of plasma deposited films in biomaterial applications [1]. More information can be found in the article of Ratner et al [15].…”

Section: Introductionmentioning

confidence: 99%

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Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,406

652

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Plasma-surface modification (PSM) is an effective and economical surface treatment technique for many materials and of growing interests in biomedical engineering. This article reviews the various common plasma techniques and experimental methods as applied to biomedical materials research, such as plasma sputtering and etching, plasma implantation, plasma deposition, plasma polymerization, laser plasma deposition, plasma spraying, and so on. The unique advantage of plasma modification is that the surface properties and biocompatibility can be enhanced selectively while the bulk attributes of the materials remain unchanged. Existing materials can, thus, be used and needs for new classes of materials may be obviated thereby shortening the time to develop novel and better biomedical devices. Recent work has spurred a number of very interesting applications in the biomedical field. This review article concentrates upon the current status of these techniques, new applications, and achievements pertaining to biomedical materials research. Examples described include hard tissue replacements, blood contacting prostheses, ophthalmic devices, and other products. #

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Section: Physicochemical Plasma Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma-surface modification of biomaterials

Chu

Chen

Wang

et al. 2002

Materials Science and Engineering: R: Reports

1,406

652

View full text Add to dashboard Cite

show abstract

“…It is known that plasma treatment may cause etching on the surface of the membrane [51]. This may result in the disruption of the dense skin layer and the semi-permeable character of the membrane.…”

Section: Transport and Mechanical Properties Of The Membranesmentioning

confidence: 99%

Immobilization of superoxide dismutase/catalase onto polysulfone membranes to suppress hemodialysis-induced oxidative stress: A comparison of two immobilization methods

Mahlicli

Şen

Mutlu

et al. 2015

Journal of Membrane Science

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a b s t r a c tThe objective of this study is to improve the blood compatibility of polysulfone (PSF) based hemodialysis membranes through generating antioxidative surfaces with superoxide dismutase (SOD)/catalase (CAT) enzyme couple immobilization. Enzymes were attached both covalently and ionically on the plasma treated and polyethyleneimine (PEI) deposited membranes, respectively. The loss of enzymes from PEI modified surface at the end of 4 h was found to be relatively higher during storage in phosphate buffered saline (PBS) at pH 7.4 when compared to the enzymes on the plasma treated surface. The kinetic studies indicated that SOD catalyzed the reaction in the diffusion-limited regime at all substrate concentrations and its inactivation by hydrogen peroxide was prevented in the presence of CAT. SOD/CAT coated PSF membranes were capable of reducing the levels of reactive oxygen species in blood and can significantly prolong activated partial thromboplastin time. In addition, both the adsorption of human plasma proteins and platelet activation on all modified membranes decreased significantly compared to the unmodified PSF membranes. Proposed modification methods did not affect high permeability, high mechanical strength or the non-toxic properties of the PSF membranes.

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“…A number of approaches have been applied to tailor polymer and metal surfaces for biomedical applications and to study the adhesion of proteins. Some of these include the use of graft polymerisation [5], and plasma modification techniques such as ion beam implantation and plasma polymerisation [6,7]. The atmospheric pressure plasma technique examined in this study can be employed as a post production process for surface modification of sensitive materials under low temperature ambient conditions.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Protein Adsorption on Atmospheric Plasma Deposited Coatings Exhibiting Superhydrophilic to Superhydrophobic Properties

et al. 2012

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Protein adsorption is one of the key parameters influencing the biocompatibility of medical device materials. This study investigates serum protein adsorption and bacterial attachment on polymer coatings deposited using an atmospheric pressure plasma jet system. The adsorption of bovine serum albumin and bovine fibrinogen (Fg) onto siloxane and fluorinated siloxane elastomeric coatings that exhibit water contact angles (θ) ranging from superhydrophilic (θ < 5°) to superhydrophobic (θ > 150°) were investigated. Protein interactions were evaluated in situ under dynamic flow conditions by spectroscopic ellipsometry. Superhydrophilic coatings showed lower levels of protein adsorption when compared with hydrophobic siloxane coatings, where preferential adsorption was shown to occur. Reduced levels of protein adsorption were also observed on fluorinated siloxane copolymer coatings exhibiting hydrophobic wetting behaviour. The lower levels of protein adsorption observed on these surfaces indicated that the presence of fluorocarbon groups have the effect of reducing surface affinity for protein attachment. Analysis of superhydrophobic siloxane and fluorosiloxane surfaces showed minimal indication of protein adsorption. This was confirmed by bacterial attachment studies using a Staphylococcus aureus strain known to bind specifically to Fg, which showed almost no attachment to the superhydrophobic coating after protein adsorption experiments. These results showed the superhydrophobic surfaces to exhibit antimicrobial properties and significantly reduce protein adsorption.

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Plasma treatments and plasma deposition of polymers for biomedical applications

Cited by 271 publications

References 30 publications

Plasma-surface modification of biomaterials

Plasma-surface modification of biomaterials

Immobilization of superoxide dismutase/catalase onto polysulfone membranes to suppress hemodialysis-induced oxidative stress: A comparison of two immobilization methods

Evaluation of Protein Adsorption on Atmospheric Plasma Deposited Coatings Exhibiting Superhydrophilic to Superhydrophobic Properties

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