Blood glucose concentrations during normal daily activities were measured in 106 patients with maturityonset diabetes from capillary blood samples collected on to filter paper. Samples were taken before and two hours after main meals, before going to bed, and, in 51 cases, during the night. Fasting and mid-morning values were closely correlated with the mean values over 24 hours irrespective of the type of anti-diabetic treatment being given. Postprandial blood glucose concentrations remained below 11 5 mmol/l (207 mg/100 ml) when the fasting blood glucose value was 7 0 mmol/l (126 mg/100 ml) or less, and repeated fasting blood glucose values exceeding 7-0 mmol/l were associated with raised blood glycosylated haemoglobin concentrations. Diabetic control in maturity-onset diabetes may be satisfactorily monitored by regular measurement of fasting or mid-morning blood glucose values.
Our observation of the presence of an abnormal amount of fat in the livers of rats fed a diet high in protein was first made in a series cf rats in which we were attempting to determine the stages of development of chronic nephritis. In rats placed on Liver Diet I and killed from 2 to 3 months later, we found that we could tell from the presence of fatty infiltration of the liver which rats were on the diet and which were not; whereas, we were unable to detect any difference between the kidneys of the rats on the Control or the Liver I diet. This observation led to a search for the cause of the phenomenal difference in the livers of the rats fed the 2 diets.The livers of rats fed Liver Diet I contain very large amounts of cholesterol and fat but less than the normal amount of lecithin. The --
RatNo.
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