Home monitoring of blood glucose using filter paper strips.

Suspected hypoglycaemia in out patient practice: accuracy of dried blood spot analysis

“…The source of error in this original method, incurred by requiring an accurate measurement of the volume of blood dropped onto the filter paper, was eliminated by the introduction of a paper punch for sampling an identical volume of blood-soaked paper each time . Blood spots that are too small or that have not soaked through the filter paper tend to underestimate glucose concentration and placing a second sample on an already dried spot tends to overestimate (Paisey et al, 1979). Wakelin et al (1978) and West et al (1979) further developed the technique to allow determination of blood glucose levels in patients during daily activities.…”

“…The method for dried blood spot analysis was as described by Paisey et al (1979). One droplet of arterialized venous blood at least 6 mm in diameter was placed on Whatman 4619 filter paper strips and transferred to the laboratory where they were stored for 1-7 days prior to analysis.…”

“…One droplet of arterialized venous blood at least 6 mm in diameter was placed on Whatman 4619 filter paper strips and transferred to the laboratory where they were stored for 1-7 days prior to analysis. Recovery of glucose from dried blood spots was approximately 98% at up to 3 weeks and the coefficient of variation between batches was 4% (Paisey et al, 1979). Discs of 6 mm diameter were punched from the centre of each blood spot and glucose was eluted from the filter paper by suspending the paper in 300 ml of 2 .…”

Improved diabetic control in insulin-dependent diabetics treated with insulin and glibenclamide

“…The same diet was maintained throughout the whole study. Diabetic control was assessed by patients collecting their own capillary blood glucose samples, using the capillary blood spot filter paper method (Paisey et al 1979) before and 2 h after their three main meals, on the same day of the week once a month for the duration of the study. At the end of each 3 months treatment period, the patients attended hospital after an over-night fast from midnight having omitted their morning insulin dose.…”

Monitoring blood glucose in gestational diabetes

“…Blood glucose values were obtained from the patients' own machines and therefore are potentially less accurate than via laboratory assay. Weekly home filter paper profiles3 4 would have been preferable and complimentary to the use of data from home machines.…”