Alloxan Diabetes in the Albino Rat as Influenced by Sex

Beach, Eliot F.; Bradshaw, Phoebe J.; Blatherwick, N. R.

doi:10.1152/ajplegacy.1951.166.2.364

Cited by 9 publications

(4 citation statements)

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“…Observations of the alloxan reaction in 72 male and 72 female albino rats of Wistar origin which were reported previously 1 albinos of the Osborne-Mendel strain. * These were bred in our own colony from descendants of a small stock secured from The Connecticut Agricultural Experiment Station in New Haven.f In designing the work the Osborne-Mendel rat seemed of special significance because investigation of this hereditary line in other laboratories has demonstrated it to be physiologically unique.…”

Section: Methodsmentioning

confidence: 78%

“…It is clear that while the two strains differ from each other in sensitivity to alloxan both strains show the same sort of sex divergence in susceptibility, namely, that the females are more severely affected than the males, a difference originally demonstrated in the Wistar strain. 1 Sixty-three per cent of the Osborne-Mendel females but only 30 per cent of the corresponding males developed diabetes which terminated fatally. Although alloxan treated animals classed in the subgroup "Fatal" under "Severe Diabetes" died with high blood sugars and had every evidence of severe diabetes, it is possible that other toxic damage may have contributed to the fatal issue, for it is well known that alloxan injury is not limited exclusively to the pancreas.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Strain Differences on Alloxan Diabetes in Albino Rats

Beach¹,

Bradshaw²,

Cullimore³

1956

Diabetes

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Studies in this laboratory on the details of the alloxan reaction in albino rats of Wistar parentage have revealed a number of features hitherto not reported in this or other species of experimental animal. 1 ' 2 > 3 These features include:1. Greater susceptibility of females than of males to alloxan diabetes, a sex difference not eliminated by prepubertal gonadectomy.2. Marked and delayed hypoglycemic phase of the alloxan reaction occurring at about the 24th to 37th hours after injection.3. Inability of severely diabetic animals to maintain high fasting blood sugars and the frequent occurrence of severe fasting hypoglycemia, a demonstration that alloxan diabetes in Wistar rats is of a complex and unorthodox type.It seemed strange that these characteristics of alloxan diabetes, so marked in the Wistar derivative, were not described by other workers who have observed alloxan treated rats. It appeared likely that the explanation might lie in strain differences. The present work, which explores this possibility, demonstrates that such a strain difference does in fact exist and implies diversity between strains in endocrine endowment relating to carbohydrate metabolism. EXPERIMENTALObservations of the alloxan reaction in 72 male and 72 female albino rats of Wistar origin which were reported previously 1 are compared herein with those from a similar experiment using 68 male and 66 female

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Section: Methodsmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Effect of Strain Differences on Alloxan Diabetes in Albino Rats

Beach¹,

Bradshaw²,

Cullimore³

1956

Diabetes

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“…When not focused on GDM or maternal diabetes, most of these studies use male rodents, proving problematic when applied to female rodents because of sex differences in disease severity and consequences in both rodents and humans [217]. Furthermore, several strains of female rodents, or female rodents under chemical or dietary treatment, exhibit resistance to developing diabetes [60,137–140,144–146,153,157]. Reproductive ability in some rodent strains used for diabetic studies can also be affected [119–125].…”

Section: Discussionmentioning

confidence: 99%

“…Like STZ, females of rodent strains react differently to alloxan. Albino female rats have higher susceptibility to alloxan-induced diabetes than males [ 140 ].…”

Section: Current Methods Of Studying Diabetesmentioning

confidence: 99%

Maternal diabetes negatively impacts fetal health

Corona¹,

Parchem

2022

Open Biol.

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Diabetes is a chronic metabolic disease affecting an increasing number of people. Although diabetes has negative health outcomes for diagnosed individuals, a population at particular risk are pregnant women, as diabetes impacts not only a pregnant woman's health but that of her child. In this review, we cover the current knowledge and unanswered questions on diabetes affecting an expectant mother, focusing on maternal and fetal outcomes.

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Steatopygia: The fatty acid composition of subcutaneous adipose tissue in the Hottentot

Krut

Singer

1963

American J Phys Anthropol

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Alloxan Diabetes in the Albino Rat as Influenced by Sex

Cited by 9 publications

References 0 publications

Effect of Strain Differences on Alloxan Diabetes in Albino Rats

Effect of Strain Differences on Alloxan Diabetes in Albino Rats

Maternal diabetes negatively impacts fetal health

Steatopygia: The fatty acid composition of subcutaneous adipose tissue in the Hottentot

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