Occurrence of Fatty Livers in Rats Fed a Diet Containing Dried, Whole Liver

Abstract

Our observation of the presence of an abnormal amount of fat in the livers of rats fed a diet high in protein was first made in a series cf rats in which we were attempting to determine the stages of development of chronic nephritis. In rats placed on Liver Diet I and killed from 2 to 3 months later, we found that we could tell from the presence of fatty infiltration of the liver which rats were on the diet and which were not; whereas, we were unable to detect any difference between the kidneys of the rats on the Control or the Liver I diet. This observation led to a search for the cause of the phenomenal difference in the livers of the rats fed the 2 diets.The livers of rats fed Liver Diet I contain very large amounts of cholesterol and fat but less than the normal amount of lecithin. The -- RatNo.

Choline and the dietary production of fatty livers

“…of series H, and 0036 p.c. of the control series L. Blatherwick, Medlar, Bradshaw, Post and Sawyer [1931, 1933 have produced evidence that feeding animals on whole dried liver, raw liver or certain liver extracts causes fatty livers in rats. They found that the addition of 2 p.c.…”

The effect of varying amounts of dietary cholesterol and of choline upon liver lipids

“…These results require but little discussion. It might be mentioned that the cholesterol-rich diets containing liver or egg yolk fed by Blatherwick, Medlar, Bradshaw, Post & Sawyer (1931, 1932, 1933a and by Okey, Yokela & Knock (1933-34) and Okey & Yokela (1936), contained quantities of lecithin providing amounts of choline considerably outside the range examined in the present study. It is therefore impossible to make exact comparisons, but it is obvious from Fig.…”

36. Choline and the Dietary Production of Fatty Livers

“…of series H, and 0036 p.c. of the control series L. Blatherwick, Medlar, Bradshaw, Post and Sawyer [1931 have produced evidence that feeding animals on whole dried liver, raw liver or certain liver extracts causes fatty livers in rats. They found that the addition of 2 p.c.…”