Response to Alloxan Modified by Gonadectomy

Beach, Eliot F.; Bradshaw, Phoebe J.; Blatherwick, N. R.

doi:10.1210/endo-50-2-212

Cited by 4 publications

(4 citation statements)

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“…Early phases of this investigation confirmed the observations of Beach et al (1952) that the male rat is more resistant to the diabetogenic properties oí alloxan than is the female rat. In numerous experiments in this laborator) female rats routinely became diabetic after a dose of 150 mg/kg of alloxan.…”

Section: Discussionsupporting

confidence: 82%

“…The use of alloxan to produce ex¬ perimental diabetes in the rat (Dunn Sc McLetchie 1943) has provided a con¬ venient means of studying the diabetic condition in detail. Beach et al (1952) have carried out a study of alloxan diabetes in the albino rat as influenced by sex and indicate that female rats were more susceptible to the diabetogenic action of alloxan than were male rats. In another paper (1951) the same authors indicate that gonadectomy eliminates this sexual difference to some extent once diabetes is established.…”

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confidence: 99%

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The Effects of Alloxan Diabetes on the Reproductive System of Young Male Rats

Hunt

Bailey

1961

Acta Endocrinologica

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Male rats 23 days of age were rendered diabetic by subcutaneous injections of alloxan. Diabetes was determined one week later on the basis of urine sugar concentration. At regular intervals following treatment animals were sacrificed and the testes, seminal vesicles and prostate gland removed for histological study. Severe diabetes resulted in failure of descent of the testes, failure of development of the germinal epithelium and castrate-type accessory organs. A more moderate diabetic condition resulted in delayed testicular descent, delayed onset of spermatogenesis and development of accessory structures. Control rats maintained on an inadequate diet were comparable to the moderate diabetics. Treatment with insulin corrected all the deleterious effects of diabetes on the reproductive system. In diabetic animals, not receiving insulin, treatment with chorionic gonadotrophin resulted in hypertrophy of interstitial cells and some development of accessory structures, but did not bring about testicular descent nor onset of spermatogenesis. Treatment with testosterone stimulated accessory structures, but did not affect testicular descent.Numerous studies, both of a clinical and experimental nature, have been made regarding the effects of diabetes on the reproductive behavior in the female. Less attention seem to have been paid to the effects in the male. Bergqvist (1954) has reviewed the material pertinent to sterility in human male diabetics and on the basis of the observed decrease in excretion of 17-ketosteroids con¬ cluded that the results indicate one or more of three possibilities. First, that diabetes in its disturbance of body metabolism involves also a disturbance of

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Section: Discussionsupporting

confidence: 82%

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confidence: 99%

The Effects of Alloxan Diabetes on the Reproductive System of Young Male Rats

Hunt

Bailey

1961

Acta Endocrinologica

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“…When not focused on GDM or maternal diabetes, most of these studies use male rodents, proving problematic when applied to female rodents because of sex differences in disease severity and consequences in both rodents and humans [217]. Furthermore, several strains of female rodents, or female rodents under chemical or dietary treatment, exhibit resistance to developing diabetes [60,[137][138][139][140][144][145][146]153,157]. Reproductive ability in some rodent strains used for diabetic studies can also be affected [119][120][121][122][123][124][125].…”

Section: Discussionmentioning

confidence: 99%

“…Like STZ, females of rodent strains react differently to alloxan. Albino female rats have higher susceptibility to alloxan-induced diabetes than males [140].…”

Section: Alloxanmentioning

confidence: 94%

Maternal diabetes negatively impacts fetal health

Corona¹,

Parchem

2022

Open Biol.

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Diabetes is a chronic metabolic disease affecting an increasing number of people. Although diabetes has negative health outcomes for diagnosed individuals, a population at particular risk are pregnant women, as diabetes impacts not only a pregnant woman's health but that of her child. In this review, we cover the current knowledge and unanswered questions on diabetes affecting an expectant mother, focusing on maternal and fetal outcomes.

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Die Androgene des Hodens in ihren Beziehungen zu den anderen endokrinen Drüsen

Voss¹

1973

Androgene I

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Response to Alloxan Modified by Gonadectomy

Cited by 4 publications

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The Effects of Alloxan Diabetes on the Reproductive System of Young Male Rats

The Effects of Alloxan Diabetes on the Reproductive System of Young Male Rats

Maternal diabetes negatively impacts fetal health

Die Androgene des Hodens in ihren Beziehungen zu den anderen endokrinen Drüsen

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