Background/Aims: Non-alcoholic steatohepatitis (NASH) lacks effective medical treatment.Since tumor necrosis factor alpha (TNF-α) plays an important role in NASH pathogenesis, we aimed to investigate drugs affecting TNF-α as possible treatment options during the development of NASH. Materials and Methods: A total of 35 rats were divided into five groupsand evaluated over a 6week period. One group received a normal diet alone or in combination with the administration of infliximab, adalimumab or pentoxifylline Results: NASH was successfully established in the MCD diet group. Levels of TNF-α were effectively suppressed in the three groups that received anti-TNF agents. No statistically significant differences were observed between the three agents in terms of the histological NASH score. Conclusion: Our study showed that the anti-TNF agents infliximab, adalimumab, and pentoxifylline effectively suppress TNF-α. Although these drugs did not prevent the development of NASH, they were able to slightly reverse the NASH histopathology score and positively affect liver function tests

Myxoinflammatory fibroblastic sarcoma (MIFS) is a recently described, rare low-grade sarcoma. Generally located in the upper and lower extremities, MIFS clinically mimics a benign cystic mass and is composed of spindle-like or atypical cells and mixed inflammatory infiltrates located in the fibroblastic myxoid stroma. Radiologic images and macroscopic appearance generally resemble a lobulated mass with irregular margins. We present a case of a tumoral mass with neoplastic cells at the center and a smooth surface with a previously undefined appearance. Myxoinflammatory fibroblastic sarcoma is significantly difficult to distinguish clinically from benign lesions and the surgeon should consider the possibility of malignancy in lesions located at the extremities.

Solitary fibrous tumors are unusual neoplasms that are rarely found in the liver parenchyma. They are usually described as hard, grayish white, well-defined lesions. Predominant cystic change in a solitary fibrous tumor is an unexpected finding, with only a few previous cases reported in the literature, two of which are localized in the head and neck region. Herein, we report a unique case of solitary fibrous tumor of the liver in a 38-year-old female with predominant multiloculated cystic appearance, and discuss the histopathologic differential diagnosis.

One of the most common post-operative deficiencies after bariatric surgery is iron deficiency and one of the important determinants of post-operative iron deficiency is the preoperative condition. In this study, it was aimed to investigate the relationship between iron levels and histopathological findings observed in gastric tissue resected in sleeve gastrectomy. Preoperative and postoperative iron levels were compared with the presence of inflammation, atrophy, Helicobacter pylori, intestinal metaplasia, lymphoid follicles, and lymphoid aggregates observed in patients operated due to morbid obesity. The postoperative serum iron levels and preoperative values were compared and a statistically significant increase was found due to the use of iron-containing preparations after the operation. Among the parameters evaluated, inflammation, atrophy, Helicobacter pylori, intestinal metaplasia, and the presence of lymphoid follicles were not found to be associated with iron levels, but it was noted that the presence of lymphoid aggregate in all cases and male cases was correlated with preoperative low iron levels (p values 0.047 and 0.015 respectively). In this study, which investigated the role of histopathological findings in the prediction of iron deficiency in sleeve gastrectomies, the relationship between preoperative iron levels, which was reported to be predictive for post-operative iron deficiency, and the presence of lymphoid aggregates was revealed. It is thought that other histopathological findings such as the presence of lymphoid follicle and Helicobacter pylori are also important in terms of iron levels but could not be revealed due to the limitations of the study.

Barret özofagusu, özofagus adenokarsinomları için öncül bir lezyon olarak kabul edilir. Endoskopik incelemenin önemli yer tuttuğu Barret özofagusu için histopatolojik inceleme gereklidir. Histopatolojik incelemelerde hematoksilen & eozin (H&E) ve alcian blue (AB) ile intestinal metaplazi ortaya çıkarılır. Bu konuda 2 farklı görüş mevcuttur. Bunlardan biri, rutin H&E boyamasında intestinal metaplaziden şüphelenildiğinde AB veya Periodic acid schiff alcian blue (PAS-AB) için histokimyasal inceleme yapmak, diğeri ise tüm özofagus biyopsilerinde H&E boyaması yanı sıra rutin olarak AB veya PAS-AB ile histokimyasal inceleme yapmaktır. Bu çalışma, intestinal metaplazinin değerlendirilmesinde H&E ve AB boyama yöntemlerinin rolünü ortaya koymayı amaçlamaktadır. Çalışmaya 200 özofagus endoskopik biyopsisi dahil edildi. Biyopsi kesitleri iki patolog tarafından kör olarak yeniden değerlendirildi. H&E ve Periodic acid schiff alcian blue (PAS-AB) boyaları sensitivite, spesifite ve pozitif prediktivite açısından karşılaştırıldı. İstatistiksel analizde intestinal metaplazinin değerlendirilmesinde H&E ve AB arasında güçlü bir korelasyon bulundu (Kendall, p = 0,00; r = 0, 81). PAS-AB boyalı kesitlerde sensitivite %100, spesifite %100, pozitif prediktivite %100, negatif prediktivite %100 iken; H&E değerlendirmesinde, sensitivite %79, spesifite %100, pozitif prediktivite %100, negative prediktivite %82.6'dır. İntestinal metaplazinin histopatolojik değerlendirmesinde temel amaç pozitif olguları tespit etmektir. İntestinal metaplazinin yokluğu daha az önemli olduğundan H&E kesitlerde gözlenen %100 spesifite ve pozitif prediktivite değerleri yerine; daha yüksek sensitivite ve negatif prediktivite değerleri tercih edilmelidir. Bu koşullar göz önünde bulunduruldğunda, AB içeren yardımcı bir histokimya kullanmak mantıklı görünmektedir.