Myxoinflammatory fibroblastic sarcoma: a case report

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a recently described, rare low-grade sarcoma. Generally located in the upper and lower extremities, MIFS clinically mimics a benign cystic mass and is composed of spindle-like or atypical cells and mixed inflammatory infiltrates located in the fibroblastic myxoid stroma. Radiologic images and macroscopic appearance generally resemble a lobulated mass with irregular margins. We present a case of a tumoral mass with neoplastic cells at the center and a smooth surface with a previously undefined appearance. Myxoinflammatory fibroblastic sarcoma is significantly difficult to distinguish clinically from benign lesions and the surgeon should consider the possibility of malignancy in lesions located at the extremities.

Giant myxoinflammatory fibroblastic sarcoma with bone invasion: a very rare clinical entity and literature review

“…Ertener et al . [10] stated that the MRI features were different from the previously described findings of a presented case report, and a hyperintense lesion with a homogenous internal structure and regular and inflammatory cell contents was observed in this case. Therefore, the MRI signal features of MIFS are nonspecific.…”

Recurrent myxoinflammatory fibroblastic sarcoma: a case report

“…The lesion was described as being hypointense with a homogenous internal structure and regular margin characteristic of a benign and cystic lesion [7]. An irregular hypointense area present in the center of the lesion motivated total excision, which confirmed the diagnosis [7].…”

“…The difficulty that exists in identifying MIFS tumors was reflected in a case of a 53year-old female who was diagnosed with a smooth, painless, cystic mass of 2 9 2 cm on her right ankle [7]. The lesion was described as being hypointense with a homogenous internal structure and regular margin characteristic of a benign and cystic lesion [7]. An irregular hypointense area present in the center of the lesion motivated total excision, which confirmed the diagnosis [7].…”

“…Lang et al drew attention to the notion that heterogenous hyperintense areas may be found in conjunction with focal hypointense areas on T2‐weighted sequences, yielding the potential for confusion with the characteristics of giant cell tumors . The difficulty that exists in identifying MIFS tumors was reflected in a case of a 53‐year‐old female who was diagnosed with a smooth, painless, cystic mass of 2 × 2 cm on her right ankle . The lesion was described as being hypointense with a homogenous internal structure and regular margin characteristic of a benign and cystic lesion .…”

Myxoinflammatory Fibroblastic Sarcoma of the Scalp

“…Although the numbers studied are relatively few, α1-antitrypsin, EGFR, and CD163 are reported to be consistently positive. [2][3][4]6,7,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] Genetically, MIFS has been shown to be associated with t(1;10)(p22:q24), with rearrangements of the TGFBR3 and MGEA5 genes on 1p22 and 10q24. This causes upregulation of the FGF8 gene, which can be visualized in some cases using immunohistochemistry for the antigen FGF8.…”