Background: Abnormalities in serum lipids and lipoprotein levels with essential hypertension are vital independent causal factors for atherosclerotic cardiovascular disease (ASCVD). The coexistence of these factors has a synergistic effect in heightening the risk of cardiovascular events. The aim of the study was to evaluate the pattern of dyslipidemia among hypertensives and to determine some of its correlations in patients attending a tertiary hospital in South South Nigeria. Methods: This was a cross-sectional study conducted on 544 eligible hypertensive patients attending the Cardiology Clinic, University of Uyo Teaching Hospital (UUTH), Uyo, Nigeria, over a period of 6 months. Fasting lipids, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were evaluated. Results: Overall, 60.0% of the hypertensive patients had dyslipidemia, with 43.4.0% having high TC, 30.3% high LDL-C, 20.8% elevated TG, and 12.9% low HDL-C, respectively. There was a significant relationship between gender and lipoproteins, with women having significantly higher lipoproteins (TC, HDL-C, LDL-C, and non-HDL-C) than men. Women also had more measures of obesity with a higher body mass index and waist circumference. TC and non-HDL had a significant association with both systolic and diastolic blood pressure (BP). Altogether, 43.4% of the hypertensives had poorly controlled BP and significantly higher atherogenic lipoproteins (TC, LDL-C, and non-HDL-C). Conclusion: This study has demonstrated the relatively high prevalence of dyslipidemia among hypertensive patient in this population. High plasma TC is the most dominant pattern of dyslipidemia. Hypertensive patients with poorly controlled BP have worse atherogenic lipoprotein values and are more likely predisposed to ASCVD.

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<b><i>Background:</i></b> Unlike what obtains in childhood-onset type 1 diabetes, there remains a paucity of data on adult-onset type 1 diabetes in Nigeria. Hence, the current study aimed to determine the general characteristics of adult-onset type 1 diabetes among subjects (aged ≥18 years) presenting at the University of Uyo Teaching Hospital (UUTH) in Akwa Ibom State, South-south Nigeria. <b><i>Methods:</i></b> A 5-year (2014–2018) retrospective records review of subjects with type 1 diabetes was undertaken, using hospital medical records retrieved from the Department of Health Information Management of UUTH. Diagnosed adult cases of type 1 diabetes were meticulously identified and the relevant data at the point of initial diagnosis were acquired on a specially designed data acquisition template. <b><i>Results:</i></b> A total of 47,357 medical cases were identified of which 362 adults were diagnosed with type I diabetes (mean age 33.12 ± 4.40, range 20–51 years) and the females (<i>n</i> = 204; 56.4%) predominated among those diagnosed. The overall, male gender, and female gender prevalence was 7.4/1,000 (95% confidence interval [CI]: 6.89–7.98), 3.3/1,000 (95% CI: 2.52–4.08), and 4.3/1,000 (95% CI: 3.61–4.99), respectively. The females exhibited the highest trough, peak, annual, and overall prevalence during the study period. The female gender (OR: 2.334; 95% CI: 1.407–3.478; <i>p</i> = 0.010), age ≤30 years (OR: 1.976; 95% CI: 0.875–3.211; <i>p</i> &#x3c; 0.001), urban-dwelling (OR: 3.243; 95% CI: 2.3407.780; &#x3c;0.001), diabetes family history (OR: 1.365; 95% CI: 0.678–2.010; <i>p</i> = 0.033), and the rainy season (OR: 1.129; 95% CI: 0.401–1.910; <i>p</i> &#x3c; 0.001) were independent predictors among the overall adult type 1 diabetics. On gender-segregated analyses, age ≤30 years, urban-dwelling, diabetes family history, and the rainy season remained independent predictors among the male and female adult type 1 diabetics (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> The study demonstrated a high burden of type 1 diabetes among adult residents of Uyo, Akwa Ibom State, South-South Nigeria. The predictors of adult type 1 diabetes, identified in the present study, are valuable epidemiologic evidence for the design of type 1 diabetes-targeted preventive programs by various concerned stakeholders.

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Background: Stroke is one of the leading causes of morbidity and mortality globally. In recent time, there is increasing evidence that suggest that increased plasma fibrinogen is associated with increased risk of stroke with unfavourable clinical outcome. Objectives: To determine the plasma fibrinogen levels in stroke patients and compare with healthy controls. Study Design: The study design was Prospective case- control study.  Place and Duration of Study: The study was conducted in the department of Internal Medicine (Neurology Unit) and the department of Haematology between March to August, 2019. Methodology: A case- control study consisting of 41 patients (21M: 19F) diagnosed with stroke in line with WHO definition and confirmed by CT-Scan of the brain were recruited consecutively into the study. 20 (10M: 10F) healthy age and gender matched consenting adults were used as controls. Plasma fibrinogen was determined for both the patients and controls using ELISA method. Also, socio-demographic and clinical data were collected using questionnaire designed for the study. The level of significance was set at P=.05. Results: The mean plasma fibrinogen level of 458.0 ± 89.1 was significantly higher in the stroke patients compared to the controls 307.8 ± 61.5 (P<0.001). An increasing level of plasma fibrinogen was observed with increasing age in both the patients and controls. However, this increase was not statistically significant (P=0.98). Also, the plasma fibrinogen level was significantly higher in the female patients (501.21±83.96) than the males 420.59±77.02 (P=0.003). Conclusion: Plasma fibrinogen was significantly higher in the stroke patients compared to the controls with female patients having a significantly higher levels than males. Also, the plasma fibrinogen levels appear to increase proportionally with increasing age.

Background: Epidemiologic data indicate that the incident characteristics of type 2 diabetes mellitus (T2DM) are proper metrics to accurately define the true trajectory of the metabolic disorder. However, this is poorly characterized among Nigerians with T2DM. Hence, the current study evaluated the incident characteristics (pattern/trend) of T2DM among adult inhabitants of Akwa Ibom State, South-south Nigeria. Methods: A retrospective survey of incident adult-onset T2DM in the University of Uyo Teaching Hospital (UUTH) was conducted using 5-year (2014-2018) hospital medical data. Records of eligible cases were identified, relevant data retrieved on a well-designed research pro forma at the point of diagnosis, and acquired data analyzed using descriptive/comparative statistics. Results: A total of 47,357 adults with varied medical conditions presented in UUTH during 2014-2018 of whom 2,198 (mean age: 55.09±11.86 years) were diagnosed with T2DM, giving an overall crude incident rate (CIR) of 4.64% (95% Confidence Interval [CI]: 3.61-6.91) and age-standardized incidence rate (ASIR) of 5. ). An increasing trend of the annual incident cases, CIR, and ASIR of T2DM was observed during the period (p trend <0.001). The increase was obvious among both genders, young adults, middle-aged, urban dwellers, tertiary-level educated, paralleling the rising low physical activity, overweight, and obesity (p trend <0.05). However, a decreasing trend of the CIR and ASIR was observed among the rural-dwellers (p trend <0.05). Conclusion: The incidence of adult-onset T2DM has assumed an upward trend among inhabitants of Akwa Ibom State, South-south Nigeria. Public health measures are urgently recommended to stem this trend.

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