Severity Grade Assessment Classifications for Both Insulin Resistance Syndrome and Status of Pancreatic Beta Cell Function in Clinical Practice Using Homeostasis Model Assessment Method Indices

Fasipe, Olumuyiwa John; Ayoade, Olufisayo Gabriel; Enikuomehin, Adenike Christiana

doi:10.1016/j.jcjd.2020.02.003

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…C-peptide is more stable and is considered an effective substitute for insulin. 29 Moreover, the bone density we measured was based on the lumbar spine, which might also cause inconsistent results. It has been reported 30 that significant insulin resistance in T2DM patients is associated with low bone density.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

Wang¹,

Jiang²,

Shao³

2021

TCRM

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Background: To explore the relationship between insulin resistance and osteoporosis risk in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: A total of 234 T2DM patients were retrospectively analyzed, and their lumbar bone mineral density (BMD) and insulin resistance using C-peptide-based homeostasis model of insulin resistance [HOMA-IR (CP)] were assessed. Univariate and multivariable logistic regression methods were used to evaluate the association between HOMA-IR (CP) and osteoporosis, and subgroup analysis was performed on female and male patients. Results: After fully adjusting the covariates, the association between HOMA-IR (CP) and osteoporosis was only significant in female patients (P = 0.022); the interaction effect with gender was significant (P for interaction <0.05). Curve fitting showed that the relationship between HOMA-IR (CP) and osteoporosis in women was nonlinear. When HOMA-IR (CP) is <4.00, its effect on osteoporosis was not significant (P = 0.474); when HOMA-IR (CP) is >4.00, the risk of osteoporosis increased significantly, with OR = 26.88 (95% CI: 2.75-262.69, P = 0.005). The relationship between insulin resistance and osteoporosis risk in T2DM patients is significantly affected by gender. Conclusion:The higher the degree of insulin resistance in female patients, the greater the risk of osteoporosis, but the two are not linearly associated.

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Section: Discussionmentioning

confidence: 99%

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

Wang¹,

Jiang²,

Shao³

2021

TCRM

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“…With regard to the evaluation method of IR, the gold standard is the euglycemic-hyperinsulinemic clamp, and others include the insulin suppression test, 2 homeostasis model assessment-IR, 3 and the quantitative insulin sensitivity check index. 4 Because of the difficulty in technical use of these methods, their overall complexity, and the nature of the population, their clinical applications are relatively limited.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Zhao¹,

Tang²,

Zheng

et al. 2021

RMHP

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Purpose This study aimed to examine whether 25-hydroxyvitamin D (25OHD) levels (an indicator of vitamin D status) are independently associated with insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM). Patients and Methods This was a cross-sectional study. Participants with T2DM were recruited from the Department of Endocrinology in Hebei General Hospital according to inclusion and exclusion criteria. Data on basic characteristics and blood parameters were collected. We used the IR index (20/[fasting C-peptide × fasting plasma glucose]) to evaluate IR. Potential confounding factors were selected from comparisons among different IR index groups of quartiles and were adjusted in different models. Results We included 172 subjects (121 men and 51 women) whose mean age was 53.2±10.6 years. Body mass index (BMI), DM course, insulin use, glycated hemoglobin (HbA1c), fasting blood glucose, fasting C-peptide, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), and albumin were differed among different IR-index groups (all P value <0.05). In models 1 and 2, no or some confounding factors were adjusted for, and we found that there was no relationship between 25OHD and the IR index. In model 3, when all confounding factors (DM course, insulin use, BMI, HbA1c, TG, HDL-C, ApoA1, albumin and other bone turnover markers) were adjusted for, the IR index was increased by 5.6% when 25OHD levels increased by 1 ng/mL (odds ratio: 1.056; 95% confidence interval: 1.009, 1.105). Conclusion Vitamin D is independently associated with IR in patients with T2DM.

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“…Evaluation of islet function is important for patients with T2DM because it is usually used to assess the progress of T2DM and to guide drug usage. Traditionally, homeostasis model assessment (HOMA)-β has been used to evaluate islet function using fasting blood glucose (FBG) and insulin levels [1], but this is only used in patients who have not received insulin therapy; therefore, its application is limited for patients who have received injected insulin. Li [2] found that a modified HOMA-β that replaces insulin with fasting C-peptide (FCP) could be used in all patients whether or not they have taken insulin.…”

Section: Introductionmentioning

confidence: 99%

The relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus

et al. 2021

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Background The aim of the study was to explore the relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus. Methods The participants were recruited from Hebei General Hospital. Basic characteristics and blood indicators were collected after fasting overnight. The data were analyzed statistically using SPSS 22.0. Analysis of variance, a nonparametric test, or a trend Chi-square test was used for the comparisons. The association between 25-hydroxy vitamin D and modified homeostasis model assessment-β was assessed using multivariate ordinal logistic regression. Results One hundred seventy-four patients aged 26 to 79 years with type 2 diabetes mellitus were included in this study. Patients with vitamin D deficiency had a lower modified homeostasis model assessment-β level compared with those without vitamin D deficiency. There were differences in body mass index, diabetes course, glycosylated hemoglobin, fasting blood glucose, fasting blood C-peptide, triglyceride, and 25-hydroxy vitamin D among different modified homeostasis model assessment-β groups based upon the tertiles. 25-hydroxy vitamin D, as continuous or categorical variables, was positively related to modified homeostasis model assessment-β whether or not cofounding factors were adjusted. Conclusion There is an association between increased 25-hydroxy vitamin D levels and improvement in modified homeostasis model assessment-β function in patients with type 2 diabetes mellitus. Trial registration Cross-sectional trails ChiCTR2000029391, Registration Date: 29/01/2020.

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Severity Grade Assessment Classifications for Both Insulin Resistance Syndrome and Status of Pancreatic Beta Cell Function in Clinical Practice Using Homeostasis Model Assessment Method Indices

Cited by 5 publications

References 27 publications

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus

The relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus

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