Мета роботи. На підставі аналітичного огляду літературних даних виділити групу високотоксичних хімічних речовин, котрі за останні десятиліття найчастіше використовуються в умисних кримінальних та суїцидальних інцидентах, диверсійних і терористичних актах, обіг, зберігання, використання та утилізацію яких потрібно особливо прискіпливо контролювати правоохоронним органам. Матеріали та методи. Аналітичний огляд наукових публікацій виконаний з використанням реферативних баз даних наукових бібліотек Pub Med, Medline і текстових баз даних наукових видавництв Elsevier, Pub Med, Central, BMJ group та інших VIP-баз даних. Використано методи системного, порівняльного та контент-аналізу. Результати та висновки. Проаналізовано наукові публікації щодо небезпечних високотоксичних хімічних речовин, які за останню чверть сторіччя найчастіше використовуються у світі, зокрема в умисних кримінальних та суїцидальних інцидентах, диверсійних і терористичних актах. Установлено, що до них переважно відносяться: рицин, сполуки талію, фосфорорганічні сполуки та бойові отруйні речовини, миш’як і його сполуки, ціаніди та неорганічні водорозчинні сполуки ртуті (сулема, мертіолят натрію), а також пестициди паракват і дикват. На основі аналізу їхньої токсичності, клінічних та морфологічних проявів інтоксикації за різних шляхів надходження до організму обґрунтовано необхідність внесення їх до Переліку особливо небезпечних хімічних речовин, обіг яких, зберігання, використання та утилізація потребують більш жорсткого контролю правоохоронних органів. У першій частині даної статті представлені рицин, сполуки талію, фосфорорганічні сполуки та бойові отруйні речовини. Ключові слова: високотоксичні небезпечні хімічні речовини, рицин, сполуки талію, фосфорорганічні сполуки.

Object . Analysis of pesticide regulations documents and scientific works regarding processed agricultural products. Results. The principles to establish maximum residue levels (MRLs) for active ingredients of pesticides in raw agricultural commodities (RACs) and processed products are currently available in the European Union and Ukraine and are provided by the WHO Commission “Codex Alimentarius” and the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) were reviewed. The European Food Safety Authority (EFSA) project with the overall objective is to develop a database of validated processing factors based on the residue definitions for enforcement, which is compatible with the EFSA food classification and description system was outlined. The European Association of Plant Producers of the EU Vegetable Oil and Proteinmeal Industry (FEDIOL) position on pesticide MRLs in vegetable oils and fats were described. This concept has identified two main elements allowing to give an indication of the fat solubility of an substances. In particular, variants of interpretation of the octanol/water partition coefficient (log Pow) were analyzed. It can be used to predict whether the substance is fat - or water-soluble and to provides an estimate of the tendency of a active ingredients of pesticides to bioaccumulate in fat. In the case of vegetable oils, MRLs can be approximated based on the physico/chemical properties of the pesticides and on the oil content of the raw agricultural commodities (theoretical processing factors from oilseeds seed to oil). Conclusions. The review determines the necessity of improve Ukrainian pesticides regulation procedure and the development of a risk-oriented approach to the selection of priority indicators for the set of MRLs of pesticides in agricultural processed products. Key Words: pesticides, residues, processed products, oilseeds.

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Abstract. Aim. Substantiation of priority indicators for establishing the maximum permissible levels (MPL) for active substances of pesticides in vegetable oils in accordance with modern international requirements and taking into account the peculiarities of their application in agriculture of Ukraine. Results. Based on the analysis of international and existing in Ukraine approaches to the development of MPL for pesticides in processed agricultural raw materials, criteria for assessing the need for research to determine and regulate the residual amounts of active substances of PPP in vegetable oils were suggested. The following main indicators that must be taken into account when normalizing pesticides in oils are substantiated: physicochemical and toxic properties of the active substance, the predicted level of its residual amounts in agricultural raw materials, the impact of technological processing on pesticide content. The principles of calculation of MPL for pesticides in oils of vegetable origin are given based on theoretical processing factors based on the FEDIOL concept, with the values of the partition coefficient between n-octanol and water and oil content in agricultural raw materials (seeds or grains of oilseeds) taken into account. The proposed concept is a basic one and provides for its further refinement and adjustment, in particular in accordance with the results of further studies on the regulation of plant protection products, which are currently relevant in the European Union. Conclusions. Methodological approaches to the establishment of MPLs for pesticides in vegetable oils need to be improved taking into account the international provisions and recommendations, set out in the article, in order to harmonize them and optimize the procedure for exporting plant products containing pesticide residues and introduction into the pesticide regulation system in Ukraine. Key Words: pesticides, residual quantities, norm setting, processed products, oilseeds.

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ABSTRACT. Flupyradifurone is an insecticide recommended to protect vineyards, apple, pear trees and cabbage in agriculture. For the state registration in Ukraine, toxicological and hygienic assessment of flupyradifurone and its insecticidal product Sivanto Prime 200 SL was performed. Acceptable daily intake of flupyradifurone for human was justified at the level of 0.02 mg/kg; hygienic standards for flupyradifurone and regulations for the safe use of insecticide Sivanto Prime 200 SL, in agriculture were developed. Objective. Toxicological and hygienic assessment of flupyradifurone and its insecticidal preparation, evaluation of the risk of rural labourers and population exposure. Methods. Expert and analytical, toxicological, physical and chemical, statistical and hygienic. Results. Based on acute toxicity parameters for different ways of exposure, flupyradifurone and Sivanto Prime 200 SL are rated as hazard class II. Long-term effects (carcinogenicity, mutagenicity and teratogenicity, reproductive and developmental toxicity) are not limiting criteria when assessing flupyradifurone hazard. Field trials have shown that residual flupyradifurone was not detectable in grapes, apples, pears and cabbage during harvesting. Occupational risk degree under inhalation and cutaneous exposure of labours to flupyradifurone was within the acceptable level. Conclusion. Use of flupyradifurone-based insecticide Sivanto Prime 200 SL for the protection of vineyards, apple, pear trees and cabbage as per agricultural and hygienic standards and regulations will not lead to contamination of agricultural products and environmental objects and will be safe for the population. Keywords: insecticide, flupyradifurone, toxicological properties, hygienic standards and regulations, hazard assessment.

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