Object . Analysis of pesticide regulations documents and scientific works regarding processed agricultural products. Results. The principles to establish maximum residue levels (MRLs) for active ingredients of pesticides in raw agricultural commodities (RACs) and processed products are currently available in the European Union and Ukraine and are provided by the WHO Commission “Codex Alimentarius” and the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) were reviewed. The European Food Safety Authority (EFSA) project with the overall objective is to develop a database of validated processing factors based on the residue definitions for enforcement, which is compatible with the EFSA food classification and description system was outlined. The European Association of Plant Producers of the EU Vegetable Oil and Proteinmeal Industry (FEDIOL) position on pesticide MRLs in vegetable oils and fats were described. This concept has identified two main elements allowing to give an indication of the fat solubility of an substances. In particular, variants of interpretation of the octanol/water partition coefficient (log Pow) were analyzed. It can be used to predict whether the substance is fat - or water-soluble and to provides an estimate of the tendency of a active ingredients of pesticides to bioaccumulate in fat. In the case of vegetable oils, MRLs can be approximated based on the physico/chemical properties of the pesticides and on the oil content of the raw agricultural commodities (theoretical processing factors from oilseeds seed to oil). Conclusions. The review determines the necessity of improve Ukrainian pesticides regulation procedure and the development of a risk-oriented approach to the selection of priority indicators for the set of MRLs of pesticides in agricultural processed products. Key Words: pesticides, residues, processed products, oilseeds.
Abstract. Aim. Substantiation of priority indicators for establishing the maximum permissible levels (MPL) for active substances of pesticides in vegetable oils in accordance with modern international requirements and taking into account the peculiarities of their application in agriculture of Ukraine. Results. Based on the analysis of international and existing in Ukraine approaches to the development of MPL for pesticides in processed agricultural raw materials, criteria for assessing the need for research to determine and regulate the residual amounts of active substances of PPP in vegetable oils were suggested. The following main indicators that must be taken into account when normalizing pesticides in oils are substantiated: physicochemical and toxic properties of the active substance, the predicted level of its residual amounts in agricultural raw materials, the impact of technological processing on pesticide content. The principles of calculation of MPL for pesticides in oils of vegetable origin are given based on theoretical processing factors based on the FEDIOL concept, with the values of the partition coefficient between n-octanol and water and oil content in agricultural raw materials (seeds or grains of oilseeds) taken into account. The proposed concept is a basic one and provides for its further refinement and adjustment, in particular in accordance with the results of further studies on the regulation of plant protection products, which are currently relevant in the European Union. Conclusions. Methodological approaches to the establishment of MPLs for pesticides in vegetable oils need to be improved taking into account the international provisions and recommendations, set out in the article, in order to harmonize them and optimize the procedure for exporting plant products containing pesticide residues and introduction into the pesticide regulation system in Ukraine. Key Words: pesticides, residual quantities, norm setting, processed products, oilseeds.
Abstract. The scale and nature of the existing external and internal threats form the directions of international security cooperation for Ukraine, which today focus on a range of topical issues in the field of chemical, biological and radiation safety. Aim. Evaluation of the results of international cooperation of the Scientific Center in the field of chemical safety, in particular in matters related to the identification of controlled and toxic chemical substances. Materials and Methods. The results of the international activity of the Scientific Center in the field of chemical safety for the past 5 years are summarized; cooperation with international donors, representatives of the government of Ukraine, scientists and non-governmental organizations is summarized. Results. A key event in the field of international cooperation was participation in G-7 Regular Meeting within the framework of the Global Partnership (Munich, Germany, 2014), where Ukraine presented about 90 projects in three areas: chemical, biological and physical nuclear safety. The results of the implementation of OSCE Project Coordinator in Ukraine: "Integrated Chemical Safety and Security Program in Ukraine (ICSSP) (2014-2019) and "Enhancing Ukraine's Chemical Emergency Response Capacity) (2020-2021) are highly appreciated. Participation in Project Project 57: Strengthening crime scene forensics capabilities in investigating CBRN incidents in the South East and Eastern Europe Centers of Excellence Region (2018-2020) and "South East and Eastern Europe CBRN Risk Mitigation and Security Governance Program (UNICRI) (2021) had significant scientific and practical results. Conclusions. Participation in the work of international projects is invaluable in shaping the professional worldview of scientists and specialists whose activities belong to the sphere of CBRN security. The joint implementation of international initiatives provides a real opportunity for the operational implementation of new experience in practice, which is reflected in the plans of scientific works, the content of trainings and educational programs for the training of specialists who, according to their professional duties, need modern knowledge in the field of managing the consequences of CBRN threats. Key Words: chemicals, chemical safety, toxicology.
Florpyrauxifen-benzyl is a novel synthetic selective leaf herbicide of the pyridine group with an auxin mechanism of action. The drug Divixton EC (a.i. - florpyrauxifen-benzyl, 25 g/l) is suggestedfor protection of rice crops from weeds. For the state registration for agricultural use in Ukraine and to prevention of toxic impact on human health and quality of environment, risk assessment of the new plant protection product was conducted, and the safety criteria for human health and the environment were substantiated. The allowable daily dose of florpyrauxifen-benzyl for humans at the level of 0.02 mg/kg was substantiated; the hygienic standards for florpyrauxifen-benzyl in rice, working environment, air, water and soil, criteria for the control of the exposureon on workers, regulations for safe use of herbicide Divixton EC in agriculture have been developed. Objective. Toxicological and hygienic assessment of florpyrauxifen-benzyl and Divixton EC drug, substantiationof safety criteria for human health, assessment of the potential impact of florpyrauxifen-benzyl on agricultural workers and the population in case of ground and aerial spraying of the preparation for the protection of rice crops. Methods. Expert-analytical, toxicological, physical, chemical, statistical and hygienic. Results. Based on the parameters of acute toxicity for different routes of exposure, sensitizing properties and irritative effects on the mucous membranes of the eyes and the skin, florpyrauxifen-benzyl and herbicide Divixton EC are classified as moderately hazardous (category 3). Long-term effects (carcinogenicity, mutagenicity and teratogenicity, toxicity for the reproductive function and development) are not limiting criteria for the assessment of florpyrauxifen-benzyl hazard. Approved in Ukraine allowable of florpyrauxifen-ben-zyl for humans is 0.02 mg/kg. As a result of field tests conducted in Ukraine, it was found that the value of occupational risk due to inhalation and through the skin in the course of ground and aerial application of florpyrauxifen-benzyl did not exceed the accepted level, sanitary protection zones ensure the safety of herbicide application for the population and environmental objects; no residues of florpyrauxifen-benzyl were detected during the harvesting of in rice grain and rice paddy. Conclusion. Application of herbicide Divixton EC for rice protectionin accordance with agricultural and hygiene rules and regulations will not result in contamination of agricultural products and environmental objects and will be safe for population and agricultural workers. Key Words: herbicide, florpyrauxifen-benzyl, toxicological characteristics, hazard assessment, hygiene standards and regulations.
ABSTRACT. Flupyradifurone is an insecticide recommended to protect vineyards, apple, pear trees and cabbage in agriculture. For the state registration in Ukraine, toxicological and hygienic assessment of flupyradifurone and its insecticidal product Sivanto Prime 200 SL was performed. Acceptable daily intake of flupyradifurone for human was justified at the level of 0.02 mg/kg; hygienic standards for flupyradifurone and regulations for the safe use of insecticide Sivanto Prime 200 SL, in agriculture were developed. Objective. Toxicological and hygienic assessment of flupyradifurone and its insecticidal preparation, evaluation of the risk of rural labourers and population exposure. Methods. Expert and analytical, toxicological, physical and chemical, statistical and hygienic. Results. Based on acute toxicity parameters for different ways of exposure, flupyradifurone and Sivanto Prime 200 SL are rated as hazard class II. Long-term effects (carcinogenicity, mutagenicity and teratogenicity, reproductive and developmental toxicity) are not limiting criteria when assessing flupyradifurone hazard. Field trials have shown that residual flupyradifurone was not detectable in grapes, apples, pears and cabbage during harvesting. Occupational risk degree under inhalation and cutaneous exposure of labours to flupyradifurone was within the acceptable level. Conclusion. Use of flupyradifurone-based insecticide Sivanto Prime 200 SL for the protection of vineyards, apple, pear trees and cabbage as per agricultural and hygienic standards and regulations will not lead to contamination of agricultural products and environmental objects and will be safe for the population. Keywords: insecticide, flupyradifurone, toxicological properties, hygienic standards and regulations, hazard assessment.
Мета. Виділити групу високотоксичних хімічних речовин, які за останні десятиліття найчастіше використовуються в умисних кримінальних та суїцидальних інцидентах, диверсійних і терористичних актах, обіг, зберігання, використання та утилізацію яких потрібно особливо прискіпливо контролювати правоохоронним органам. У даній частині статті йдеться про сполуки миш’яку та ціаніди. Матеріали та методи. Аналітичний огляд наукових публікацій виконаний з використанням реферативних баз даних наукових бібліотек Pub Med, Medline і текстових баз даних наукових видавництв Elsevier, Pub Med, Central, BMJ group та інших VIP-баз даних. Використано методи системного, порівняльного та контент-аналізу. Результати та висновки. Проаналізовано наукові публікації, в яких йдеться про високотоксичні сполуки миш’яку та ціаніди, які становлять загрозу життю і здоров’ю людини. Останнім часом, зокрема понад чверть сторіччя, вони стали справжньою зброєю в руках злочинців, кримінальних елементів і терористів у всьому світі. Не можна замовчувати й суїцидальні інциденти, які також мають місце поряд з умисними кримінальними, терористичними та диверсійними актами. На основі аналізу токсичності, клінічних та морфологічних проявів інтоксикації цих хімічних речовин, враховуючи різні шляхи надходження до організму, обґрунтовано необхідність внесення їх до Переліку особливо небезпечних хімічних речовин, обіг яких, зберігання, використання та утилізація потребують більш жорсткого контролю з боку правоохоронних органів. Ключові слова: сполуки миш’яку, ціаніди, ризик для здоров’я, гострі отруєння.
The Aim of the Research. To identify a group of highly toxic chemicals which over the past decades are most often used in deliberate criminal and suicidal incidents, sabotage, and terrorist act; the handling, storage, use and disposal of which must be especially carefully monitored by law enforcement agencies. In this part of the article arsenic compounds and cyanide are considered. Materials and Methods. An analytical review of scientific publications was carried out using the abstract databases of scientific libraries Pub Med, Medline and text databases of scientific publishing houses Elsevier, Pub Med, Central, BMJ group as well as other VIP databases. Methods of systemic, comparative, and content analysis were used. Results and Conclusions. Scientific publications that contain information on highly toxic arsenic compounds and cyanides, which pose a threat to human life and health, were analyzed. Recently, in particular for more than a quarter of a century, they have become a real weapon in the hands of criminals, delinquents, and terrorists all over the world. Suicidal incidents, which also take place along with intentional criminal, terrorist, and sabotage acts, should not be concealed. Based on the analysis of the toxicity, clinical and morphological expression of intoxication when exposed to these chemicals, considering various routes of entry into the body, the need to include them in the List of hazardous highly toxic chemicals, the handling, storage, use, and disposal of which require stricter control of law enforcement agencies, is justified. Key Words: arsenic compounds, cyanide, health risk, acute poisoning.
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