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This study was aimed to investigate the potential harmful element (PHE) concentrations in coal dust and evaluate the human risk assessment and health effects near coal mining areas. For this purpose, dust samples were collected near various coal mines in Cherat, Pakistan, and analyzed for the PHE concentrations. Determined PHE concentrations were evaluated for the health risk assessment. Results revealed that ingestion was the major pathway as compared to others for PHE exposure. Individual chronic daily intake (CDI) of PHEs was higher than their respective permissible exposure limits set for oral exposure routes by the Agency for Toxic Substances and Disease Registry (ATSDR). Chronic risk or health index (HI) values were observed < 1 for all PHEs and in the order of Pb > Cr > Cd > Ni > Cu > Co > Zn. Higher HI values of Pb, Cr, and Cd could attribute to various chronic health problems as observed during the medical examination survey of this study. Cancer risk (CR) values for this study were observed within the US Environmental Protection Agency (EPA) limits. However, if current practices continued, the PHEs will cross these limits in a near future. Therefore, this study strongly recommends the provision of safety measures, rules, and regulation to avoid health hazards in the future.

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Enzyme inhibitory agents are atractive because of their application in treating diferent ailments. The absence of enzymes produce a number of diseases. Medicinal plants are a rich source of producing secondary metabolites which showed broad-spectrum enzyme inhibitory potential. The position of enzyme inhibitors as new drugs is vast since these compounds have been used for the treatment of various physiological disorders. Bioactive secondary metabolites can deliver excellent pharmacophore paterns for drugs related to numerous illnesses. This book chapter is planned to document the enzyme inhibitory potential of natural compounds, medicinal plant extract, and its isolated compounds.

Historically, non-Indigenous researchers have contributed to colonisation by research based on Western positivistic philosophical frameworks. This approach led to disembodying knowledge from Indigenous people's histories, worldviews, and cultural and social practices, thus perpetuating a deficit-based discourse which situates the responsibility of problems within Indigenous peoples and ignores the larger socioeconomic and historical contexts in which problems are rooted. Rectifying this position requires decolonising Western positivistic research by shifting to basing research on social constructionist paradigms that lead to strength-based approaches. Based on our experiences gained exploring disaster risk reduction perspectives with two remote Indigenous communities in Australia and Pakistan, we suggest in this conceptual paper that a synergy of systems theory and symbolic interactionism offers an appropriate philosophical lens to non-Indigenous researchers for gaining a more comprehensive and deeper understanding of Indigenous holistic and relational perspectives, experiences, interpretations and actions/ interaction. Research based on these philosophical worldviews promotes a strength-based approach that aligns with and empowers Indigenous ways of facilitating health and wellbeing. We offer our experiences of utilising these two frameworks and of how they could assist other non-Indigenous researchers to discover valuable insights into Indigenous perspectives and interpretations that might otherwise be ignored or neglected.

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Ethanolic extracts of Ferula assafoetida resin, Grewia asiatica leaves, Ipomoea hederacea seeds, Lepidium sativum seeds, Nigella sativa seeds and Terminalia chebula fruits were tested in vitro for their antibacterial and antifungal activities. The antibacterial study performed against eight bacterial species viz., Escherichia coli, Citrobacter, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, Micrococcus luteus, Proteus mirabilis and Bacillus subtilis indicated that the investigated plants have potent activity against all the tested microorganisms. The antifungal activity of these extracts was performed against nine fungal strains, viz., Aspergillus parasiticus, Aspergillus niger, Yersinia aldovae, Candida albicans, Aspergillus effusus, Fusarium solani, Macrophomina phaseolina, Saccharomyces cerevisiae and Trichophyton rubrum. The extracts showed moderate as well as significant activity against the different fungal strains