Background. Earlier we showed that profile patients of Truskavets’ spa are characterized by a wide range of blood pressure (BP) - from low norm to arterial hypertension III that correspond to the hemodynamics parameters. The purpose of this study is to clarify the autonomic and endocrine accompaniments of quantitative-qualitative BP clusters in the same contingent. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). The parameters of HRV ("CardioLab+HRV", Ukraine), plasma levels of Cortisol, Aldosterone, Testosterone, Triiodothyronine and Calcitonin (ELISA) as well as Ca-P marker of parathyroid hormone were determined. Results. In order to identify among the registered parameters, those for which the BP clusters differ from each other, a discriminant analysis was performed. The program forward stepwise included in the discriminant model 29 parameters. The most informative among them are HRV-markers of sympathetic tone and sympathetic-vagal balance as well as testosterone and cortisol, whose levels are maximal in patients with hypertension II, while minimal in patients with low norm BP, on the one hand, and markers of vagal tone and Kerdoe vegetative index, the levels of which are polar, on the other hand. The accuracy of patient classification is 98,9%. Conclusion. Autonomic and endocrine accompaniments of quantitative-qualitative blood pressure clusters corresponding to the existing ideas about the regulation of blood pressure.
Background. The influence of balneotherapy at the Truskavets’ spa on the blood pressure (BP) of his patients is still not in the focus of researchers. Therefore, we initiated the project “Neuroendocrine-immune and metabolic mechanisms of the effect of balneotherapy on BP”. The first swallow of the project is the analysis of a condition of BP and its hemodynamic support of profile patients of a resort. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). Simultaneously the parameters of hemodynamics were determined (echocamera “Toshiba-140”, Japan). Results. The optimal level of systolic BP (range 120÷129 mmHg) stated in 18,2% of cases only, high norm (130÷139 mmHg) in 14,8%, arterial hypertension (AH) I (140÷160 mmHg) – in 39,8%, AH II (over 160 mmHg) in 12,5%, however, in 14,8% of cases the BP was lower than 120 mmHg. In order to identify among the registered parameters of hemodynamics, those for which the BP clusters differ from each other, a discriminant analysis was performed. The program forward stepwise included in the discriminant model 13 parameters out of 17. The most informative among them: contractility index of left ventricle, heart work per minute, ejection fraction and time as well as end-systolic volume. Conclusion. Profile patients of Truskavets’ spa are characterized by a wide range of blood pressure - from low norm to arterial hypertension II that correspond to the hemodynamics parameters.
Background. Earlier we studied the neural, endocrine, immune, microbiome and metabolome accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The obtained results give us grounds to put forward the concept of tensioregulome by analogy with the metabolome and the microbiome. The purpose of this study is detailing this concept. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP. We determined parameters of EEG and HRV, plasma levels of adaptation hormones, electrolytes, lipids, and nitrogenous metabolites, components of humoral, cellular, and phagocytic links of immunity and markers of pyelonephritis. Results. The forward stepwise program identified 26 tensioregulome parameters as characteristic of quantitative-qualitative blood pressure clusters: 10 EEG, 6 metabolic, 6 immune, testosterone, cotrisol, sympathetic tone as well as sex. The accuracy of patient classification is 98,9%. Another 25 parameters were found to be characteristic, but were outside the discriminant model, including 11 EEG, 2 HRV, 5 metabolic, 4 immune, bacteriuria, body mass index, and age. Both linear and non-linear correlations between the BP and tensioregulome parameters were revealed. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic accompaniment named tensioregulome.
The article represents the results of the study of the micronutrient deficiency effect (iron and iodine) on the morphometric and optical indices of the oral cavity mucous membrane (OCMM) in school children. In order to achieve this goal, 99 school children aged 6-18 years with adequate iodine and iron supply (control group), latent iron deficiency, and mild iodine deficiency were examined. The morphodensitometric study included the determination of the perimeter and area of cells and nuclei, the nuclear-cytoplasmic ratio, the state of chromatin condensation of the epitheliocyte OCMM. The study material was: epitheliocytes of the buccal scraping. It was determined that the area of epitheliocytes in girls aged 6-11 has significantly increased in mild iodine deficiency and in latent iron deficiency. Instead, the decrease of nuclei area was more noticeable in boys of this age in mild iodine deficiency. During the analysis of the general level of chromatin condensation of epitheliocyte nuclei in children, a gender peculiarity has been proved, which was manifested by a greater sensitivity of girls to microelementosis (increase of the integrative optical density of nuclei in the latent iron deficiency at 97.9%, p 1-3 < 0.05, and cell area at 45.8%, p 1-4 < 0.01 relative to control). Among children aged 12-18 years,young men were more sensitive to the deficiency of the studied trace elements. Significant growth of the cell area at 38.7% (p 1-2 < 0.05) in adolescents with mild iodine deficiency and total optical density of nuclei at 63.6% (p 1-2 < 0.05) was substantiated with respect to control in the decrease of karyoplasmic area.
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