Background. Earlier we showed that profile patients of Truskavets’ spa are characterized by a wide range of blood pressure (BP) - from low norm to arterial hypertension III that correspond to the hemodynamics parameters. The purpose of this study is to clarify the autonomic and endocrine accompaniments of quantitative-qualitative BP clusters in the same contingent. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). The parameters of HRV ("CardioLab+HRV", Ukraine), plasma levels of Cortisol, Aldosterone, Testosterone, Triiodothyronine and Calcitonin (ELISA) as well as Ca-P marker of parathyroid hormone were determined. Results. In order to identify among the registered parameters, those for which the BP clusters differ from each other, a discriminant analysis was performed. The program forward stepwise included in the discriminant model 29 parameters. The most informative among them are HRV-markers of sympathetic tone and sympathetic-vagal balance as well as testosterone and cortisol, whose levels are maximal in patients with hypertension II, while minimal in patients with low norm BP, on the one hand, and markers of vagal tone and Kerdoe vegetative index, the levels of which are polar, on the other hand. The accuracy of patient classification is 98,9%. Conclusion. Autonomic and endocrine accompaniments of quantitative-qualitative blood pressure clusters corresponding to the existing ideas about the regulation of blood pressure.
Background. The influence of balneotherapy at the Truskavets’ spa on the blood pressure (BP) of his patients is still not in the focus of researchers. Therefore, we initiated the project “Neuroendocrine-immune and metabolic mechanisms of the effect of balneotherapy on BP”. The first swallow of the project is the analysis of a condition of BP and its hemodynamic support of profile patients of a resort. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). Simultaneously the parameters of hemodynamics were determined (echocamera “Toshiba-140”, Japan). Results. The optimal level of systolic BP (range 120÷129 mmHg) stated in 18,2% of cases only, high norm (130÷139 mmHg) in 14,8%, arterial hypertension (AH) I (140÷160 mmHg) – in 39,8%, AH II (over 160 mmHg) in 12,5%, however, in 14,8% of cases the BP was lower than 120 mmHg. In order to identify among the registered parameters of hemodynamics, those for which the BP clusters differ from each other, a discriminant analysis was performed. The program forward stepwise included in the discriminant model 13 parameters out of 17. The most informative among them: contractility index of left ventricle, heart work per minute, ejection fraction and time as well as end-systolic volume. Conclusion. Profile patients of Truskavets’ spa are characterized by a wide range of blood pressure - from low norm to arterial hypertension II that correspond to the hemodynamics parameters.
Background. Despite the well-documented relationships between HRV, EEG and anxiety parameters, studies of their sexual dimorphism, judging by the results of the meta-analysis, have so far been conducted separately. The purpose of this study is to clarify sexual dimorphism in almost synchronously registered psycho-neuro-endocrine parameters. Materials and Methods. The object of observation were practically healthy volunteers: 30 females (30÷76 yr) and 31 males (24÷69 yr). In basal conditions we recorded the ongoing HRV and EEG, determined serum levels of testosterone, calcitonin, cortisol, aldosterone, and triiodothyronine, estimated the severity of the trait and reactive anxiety. After 4 or 7 days, repeated testing was performed. Results. Regardless of age, females differ significantly from males, except for drastically lower levels of testosterone and calcitonin by definition (but not cortisol, aldosterone and triiodothyronine), lower levels of HRV-markers of sympathetic tone (but not heart rate), reactive anxiety, and beta-rhythm asymmetry. On the other hand, trait anxiety, levels of HRV-markers of vagal tone, variability and amplitude of the beta-rhythm, and its power spectral density (PSD) in 12 loci (maximum differences in T6, F3, and T3 loci), amplitude of the theta-rhythm and its PSD in 16 loci (maximum differences in F3, C3, and T3 loci), PSD of the alpha-rhythm in T3, T6, F7, and T4 loci as well as entropy of PSD in F7 and F8 loci are significantly higher in females than in males. The listed parameters are determined by testosterone for 31,7%, and calcitonin for 26,3%. The method of discriminant analysis revealed 20 EEG and 6 HRV parameters as well as trait and reactive anxiety, based on the totality of which males can be retrospectively recognized (without testosterone and calcitonin) with an accuracy of 90,3%, and females with an accuracy of 88,3%. Conclusion. The revealed differences between the sexes were not influenced by at least two bioactive factors, that is, they are robust sex markers.
Background. Earlier we studied the neural, endocrine, immune, microbiome and metabolome accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The obtained results give us grounds to put forward the concept of tensioregulome by analogy with the metabolome and the microbiome. The purpose of this study is detailing this concept. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP. We determined parameters of EEG and HRV, plasma levels of adaptation hormones, electrolytes, lipids, and nitrogenous metabolites, components of humoral, cellular, and phagocytic links of immunity and markers of pyelonephritis. Results. The forward stepwise program identified 26 tensioregulome parameters as characteristic of quantitative-qualitative blood pressure clusters: 10 EEG, 6 metabolic, 6 immune, testosterone, cotrisol, sympathetic tone as well as sex. The accuracy of patient classification is 98,9%. Another 25 parameters were found to be characteristic, but were outside the discriminant model, including 11 EEG, 2 HRV, 5 metabolic, 4 immune, bacteriuria, body mass index, and age. Both linear and non-linear correlations between the BP and tensioregulome parameters were revealed. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic accompaniment named tensioregulome.
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