Background. Earlier we showed that profile patients of Truskavets’ spa are characterized by a wide range of blood pressure (BP) - from low norm to arterial hypertension III that correspond to the hemodynamics parameters. The purpose of this study is to clarify the autonomic and endocrine accompaniments of quantitative-qualitative BP clusters in the same contingent. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). The parameters of HRV ("CardioLab+HRV", Ukraine), plasma levels of Cortisol, Aldosterone, Testosterone, Triiodothyronine and Calcitonin (ELISA) as well as Ca-P marker of parathyroid hormone were determined. Results. In order to identify among the registered parameters, those for which the BP clusters differ from each other, a discriminant analysis was performed. The program forward stepwise included in the discriminant model 29 parameters. The most informative among them are HRV-markers of sympathetic tone and sympathetic-vagal balance as well as testosterone and cortisol, whose levels are maximal in patients with hypertension II, while minimal in patients with low norm BP, on the one hand, and markers of vagal tone and Kerdoe vegetative index, the levels of which are polar, on the other hand. The accuracy of patient classification is 98,9%. Conclusion. Autonomic and endocrine accompaniments of quantitative-qualitative blood pressure clusters corresponding to the existing ideas about the regulation of blood pressure.
Background. The influence of balneotherapy at the Truskavets’ spa on the blood pressure (BP) of his patients is still not in the focus of researchers. Therefore, we initiated the project “Neuroendocrine-immune and metabolic mechanisms of the effect of balneotherapy on BP”. The first swallow of the project is the analysis of a condition of BP and its hemodynamic support of profile patients of a resort. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). Simultaneously the parameters of hemodynamics were determined (echocamera “Toshiba-140”, Japan). Results. The optimal level of systolic BP (range 120÷129 mmHg) stated in 18,2% of cases only, high norm (130÷139 mmHg) in 14,8%, arterial hypertension (AH) I (140÷160 mmHg) – in 39,8%, AH II (over 160 mmHg) in 12,5%, however, in 14,8% of cases the BP was lower than 120 mmHg. In order to identify among the registered parameters of hemodynamics, those for which the BP clusters differ from each other, a discriminant analysis was performed. The program forward stepwise included in the discriminant model 13 parameters out of 17. The most informative among them: contractility index of left ventricle, heart work per minute, ejection fraction and time as well as end-systolic volume. Conclusion. Profile patients of Truskavets’ spa are characterized by a wide range of blood pressure - from low norm to arterial hypertension II that correspond to the hemodynamics parameters.
Background. Earlier we studied the neural, endocrine, immune, microbiome and metabolome accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The obtained results give us grounds to put forward the concept of tensioregulome by analogy with the metabolome and the microbiome. The purpose of this study is detailing this concept. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP. We determined parameters of EEG and HRV, plasma levels of adaptation hormones, electrolytes, lipids, and nitrogenous metabolites, components of humoral, cellular, and phagocytic links of immunity and markers of pyelonephritis. Results. The forward stepwise program identified 26 tensioregulome parameters as characteristic of quantitative-qualitative blood pressure clusters: 10 EEG, 6 metabolic, 6 immune, testosterone, cotrisol, sympathetic tone as well as sex. The accuracy of patient classification is 98,9%. Another 25 parameters were found to be characteristic, but were outside the discriminant model, including 11 EEG, 2 HRV, 5 metabolic, 4 immune, bacteriuria, body mass index, and age. Both linear and non-linear correlations between the BP and tensioregulome parameters were revealed. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic accompaniment named tensioregulome.
Background. Earlier we studied the neural, endocrine, and metabolic accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The purpose of this study is to clarify the immune accompaniment in the same contingent. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP. We determined in the blood the relative content of leukocyte forms, of T-lymphocytes and their killer, helper and regulatory subpopulations as well as NK- and B-lymphocytes; in serum - the concentration of C-reactive protein, Tumor Necrosis Factor-α, Interleukins 1β and 6, immunoglobulins classes G, A, and M as well as circulating immune complexes; in saliva - IgG, IgA, and secretory IgA. In addition, we determined parameters of phagocytosis by neutrophils of Staph. aureus and E. coli; components of stool and urine microbiota. Results. The forward stepwise program identified 18 parameters as characteristic of quantitative-qualitative blood pressure clusters. In addition to BP parameters by default, the most informative among them are serum levels of IL-6 and TNF-α as well as activity and intensity of phagocytosis by neutrophils of Staph. aureus. The accuracy of patient classification is 96,6%. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic immune accompaniment.
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