Metal-organic framework (MOF) nanomaterials offer a wide range of promising applications due to their unique properties, including open micro- and mesopores and rich of functionalization. Herein, a facile synthesis via...
Electrochemical biosensors have attracted a tremendous attention for many researchers recently due to its facile synthesis process, tunability easiness by tailoring the material properties or composition, and wide range of biological analyte types detection. To obtain an excellent electrochemical biosensor performance, a material that facilitates fast electron transfer, large surface area, excellent electrocatalytic activity, and abundant available sites for bioconjugation is immensely needed. Metal-organic frameworks in the two-dimensional form (2D MOFs) provide all of the criteria needed as the sensing material for electrochemical biosensors application. However, the design and preparation of 2D MOFs, which have high stability and sensitivity as well as good selectivity for biological analyte detection, is still quite challenging. This review provides the recent studies and development of 2D MOFs as electrochemical biosensor. A detailed discussion about 2D MOFs structures, their synthesis strategy and control, 2D MOFs materials in electrochemical biosensor application, and the future challenges is thoroughly explained in this review. Hopefully, this review will also provide a new inspiration to advance future studies of 2D MOFs materials development as electrochemical biosensor.
This review highlights the recent development of mesoporous TiO2-based architectures as promising sensing materials for diagnosing diseases and detecting harmful substances in the human body.
The recent trend on metal organic framework (MOF) studies has shifted to the development of MOFs with many metal nodes, also known as multi metallic MOF (MM-MOF). Many studies have shown that MM-MOF display much better performance compared to single metallic MOFs. In addition, derived MM-MOF products such as metal hybrids, MM-MOF composites, and MOF-on-MOF also provide interesting unique characteristics. In this review, we summarize the synthesis strategy of MM-MOF and their derivates in three different approaches, including one-pot synthesis/direct mixing, post-synthesis modification, and MOFs derivative preparation. In many applications, such as cancer markers detection, diabetic disease detection, metabolic disease detection, infectious disease detection, and toxic pollutant detection, MM-MOF based biosensors displayed excellent sensing performance as well as stability, selectivity, and reproducibility. This review provides a point of view on the recent development, preparation, and application of MM-MOF including the challenge and future prospect of this material.
In this work, a metal-organic framework (MOF) based on cobalt was decorated with graphene and used as a sensing material for glucose determination with electrochemical principles. The selection of Co-MOF material is based on its porous nature, large surface area, and excellent electrochemical properties. The combination of Co-MOF with graphene (high conductivity) effectively increased the electrochemical sensor current. The fabricated composite owned the good crystallinity with graphene particles attached to the Co-MOF surface. The biosensing performance was evaluated by cyclic voltammetry (CV) with 0.1 M NaOH solution as the bolstering electrolyte. The electrochemical measurement indicated that the prepared materials possessed a well-moved transfer electron between the electrode surface and electrolyte solution. The Co-BDC-3Gr sample obtained the best electrochemical performance with the lowest limit of detection (LOD) of 5.39 μM and the highest sensitivity of 100.49 μA mM-1 cm-2. The selectivity test of the modified Co-MOF was done by comparing the response with other compounds such as dopamine, uric acid, and NaCl. The acquired biosensor had excellent stability, with 93% of the initial response after 30 days of storage.
This study reports on an enzymatic glucose sensor based on mesoporous TiO2 nanoparticles (MTNPs) synthesized by a simple solvothermal method. The unique structure of MTNPs with a fairly homogenous shape, porous, and high crystallinity is the consequence of the use of PVP yang during the synthesis process. PVP plays an important role in creating the uniform morphology and mesoporous structure of MTNPs-2. The success of glucose oxidase immobilization on the surface of MTNPs was proven by FTIR and UV–vis characterizations. The prepared GCE/MTNPs-2/GOx electrode successfully detects glucose molecules with good sensing performance with a sensitivity of 0.4098 μA mM−1 cm−2, a wide linear range of 0.1–1 mM, and a relatively low detection limit of 73 μM.
Tujuan dari pelaksanaan kegiatan pengabdian ini adalah untuk meningkatkan pendapatan UMKM di kelurahan Tembesi dengan melakukan pendampingan dan penyuluhan tentang metode pemasaran pada masa pandemi Covid-19. Metode yang digunakan adalah dengan melakukan pengecekan langsung masalah yang dihadapi oleh pelaku UMKM. Mitra dari kegiatan pengabdian masyarakat adalah enam pelaku UMKM di Kelurahan Tembesi yaitu Es campur, Distera taylor, tempe mendoan, warung makan, empek-empek, rujak. Pendapatan dari para mitra pelaku UMKM terpengaruh oleh pandemi Covid-19. Semua pelaku belum melakukan promosi dengan media sosial, sedangkan di masa pandemi Covid-19 mayoritas masyarakat mengurangi kegiatan diluar dan melakukan pembelian secara online. Pelaku UMKM yang bergerak dibidang makanan dan minuman, mayoritas belum memperhatikan kemasan dan tidak menggunakan label sebagai identitas dari pelaku UMKM. Dalam proses pendampingan dan penyuluhan mayoritas pelaku UMKM mengikuti arahan dari pelaku pengabdian masyarakat, meskipun ada 2 pelaku UMKM yang tidak bersedia menerapkan promosi dengan media sosial yaitu UMKM tempe mendoan dan rujak. Secara keseluruhan, pelaksanaan pengabdian masyarakat memberikan perubahan positif terhadap pendapatan pelaku UMKM.
Ir ) is a radionuclide currently suggested for brachyteraphy. One of the methods employed to produce high purity 192 Ir is by irradiation of Os) target using cyclotron. The success of 192 Ir radionuclide production in cyclotrons requires deep understanding of irradiation parameters, including particle energy, target preparation and thickness, particle beam curent and irradiation time. Therefore, theoretical calculations of the 192 Ir radioactivity yields should be carried out as a preliminary measure for more efficient 192 Ir production. In this study, 192 Ir production was simulated using the SRIM 2013 program to determine the optimum target thickness while the nuclear cross-section data were extracted from TENDL 2017. Two nuclear reactions for 192 Ir production yield calculations were compared, i.e., 192 Os(p,n) 192 Ir and 192 Os(d,2n) 192 Ir. The radioactivity yields for 192 Os(p,n) 192 Ir nuclear reaction was found to be lower than 192 Os(d,2n) 192 Ir reaction. For proton and deuteron energy of 30 MeV, the maximum radioactivity yield was 6.79 GBq for 192 Os(p,n) 192 Ir and 26.14 GBq for 192 Os(d,2n) 192 Ir. Several radionuclide impurities such as 191m Ir, 190 Ir, 191 Os and 189 Re were predicted to be generated during 192 Os(p,n) 192 Ir reaction for proton incident energy between 1 and 30 MeV; meanwhile, 192 Ir, 191m Ir, 193 Os, 193m Ir, 192m Os and 191 Os radionuclides were expected to contaminate during 192 Os(d,2n) 192 Ir reaction for deuteron energy between 1 and 30 MeV. Results of this study can be used as a reference for future 192 Ir radionuclide production when proton or deuteron beams are considered to be employed.
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