Metal-organic framework (MOF) nanomaterials offer a wide range of promising applications due to their unique properties, including open micro- and mesopores and rich of functionalization. Herein, a facile synthesis via...

This review highlights the recent development of mesoporous TiO2-based architectures as promising sensing materials for diagnosing diseases and detecting harmful substances in the human body.

Electrochemical biosensors have attracted a tremendous attention for many researchers recently due to its facile synthesis process, tunability easiness by tailoring the material properties or composition, and wide range of biological analyte types detection. To obtain an excellent electrochemical biosensor performance, a material that facilitates fast electron transfer, large surface area, excellent electrocatalytic activity, and abundant available sites for bioconjugation is immensely needed. Metal-organic frameworks in the two-dimensional form (2D MOFs) provide all of the criteria needed as the sensing material for electrochemical biosensors application. However, the design and preparation of 2D MOFs, which have high stability and sensitivity as well as good selectivity for biological analyte detection, is still quite challenging. This review provides the recent studies and development of 2D MOFs as electrochemical biosensor. A detailed discussion about 2D MOFs structures, their synthesis strategy and control, 2D MOFs materials in electrochemical biosensor application, and the future challenges is thoroughly explained in this review. Hopefully, this review will also provide a new inspiration to advance future studies of 2D MOFs materials development as electrochemical biosensor.

The recent trend on metal organic framework (MOF) studies has shifted to the development of MOFs with many metal nodes, also known as multi metallic MOF (MM-MOF). Many studies have shown that MM-MOF display much better performance compared to single metallic MOFs. In addition, derived MM-MOF products such as metal hybrids, MM-MOF composites, and MOF-on-MOF also provide interesting unique characteristics. In this review, we summarize the synthesis strategy of MM-MOF and their derivates in three different approaches, including one-pot synthesis/direct mixing, post-synthesis modification, and MOFs derivative preparation. In many applications, such as cancer markers detection, diabetic disease detection, metabolic disease detection, infectious disease detection, and toxic pollutant detection, MM-MOF based biosensors displayed excellent sensing performance as well as stability, selectivity, and reproducibility. This review provides a point of view on the recent development, preparation, and application of MM-MOF including the challenge and future prospect of this material.

In this work, a metal-organic framework (MOF) based on cobalt was decorated with graphene and used as a sensing material for glucose determination with electrochemical principles. The selection of Co-MOF material is based on its porous nature, large surface area, and excellent electrochemical properties. The combination of Co-MOF with graphene (high conductivity) effectively increased the electrochemical sensor current. The fabricated composite owned the good crystallinity with graphene particles attached to the Co-MOF surface. The biosensing performance was evaluated by cyclic voltammetry (CV) with 0.1 M NaOH solution as the bolstering electrolyte. The electrochemical measurement indicated that the prepared materials possessed a well-moved transfer electron between the electrode surface and electrolyte solution. The Co-BDC-3Gr sample obtained the best electrochemical performance with the lowest limit of detection (LOD) of 5.39 μM and the highest sensitivity of 100.49 μA mM-1 cm-2. The selectivity test of the modified Co-MOF was done by comparing the response with other compounds such as dopamine, uric acid, and NaCl. The acquired biosensor had excellent stability, with 93% of the initial response after 30 days of storage.