Review—Recent Trend on Two-Dimensional Metal-Organic Frameworks for Electrochemical Biosensor Application

Abstract

Electrochemical biosensors have attracted a tremendous attention for many researchers recently due to its facile synthesis process, tunability easiness by tailoring the material properties or composition, and wide range of biological analyte types detection. To obtain an excellent electrochemical biosensor performance, a material that facilitates fast electron transfer, large surface area, excellent electrocatalytic activity, and abundant available sites for bioconjugation is immensely needed. Metal-organic frameworks in the two-dimensional form (2D MOFs) provide all of the criteria needed as the sensing material for electrochemical biosensors application. However, the design and preparation of 2D MOFs, which have high stability and sensitivity as well as good selectivity for biological analyte detection, is still quite challenging. This review provides the recent studies and development of 2D MOFs as electrochemical biosensor. A detailed discussion about 2D MOFs structures, their synthesis strategy and control, 2D MOFs materials in electrochemical biosensor application, and the future challenges is thoroughly explained in this review. Hopefully, this review will also provide a new inspiration to advance future studies of 2D MOFs materials development as electrochemical biosensor.

Converging 2D Nanomaterials and 3D Bioprinting Technology: State‐of‐the‐Art, Challenges, and Potential Outlook in Biomedical Applications

“…[243] Adjacent layers in the MOFs layered crystal structures connected with weak van der Waals forces that can be exfoliated into individual nanosheets by a variety of methods and synthesize 2D MOFs. [244] Compared to the bulk MOFs, the 2D nanostructure of MOFs possessed several merits including ) Endow photothermal effect along with improved tissue formation. [174] Reproduced with permission.…”

Multimodal/Multifunctional Nanomaterials in (Bio)electrochemistry: Now and in the Coming Decade

“…Recently, ultra-thin MOFs layers with large surface area and excellent electrocatalytic activity, a high number of accessible sites for biomolecular adsorption and, most importantly, good dispersibility in solution, have been synthesized [ 70 ]. In this context, Li et al reported the preparation of a Co-MOF nanosheet array on nickel foam (NF) which was used as the sensing material for the non-enzymatic electrochemical detection of glucose on the basis of the high electrocatalytic effect towards glucose oxidation.…”

A Comprehensive Review of Metal–Organic Framework: Synthesis, Characterization, and Investigation of Their Application in Electrochemical Biosensors for Biomedical Analysis

“…It is possible to largely enhance the function of electrochemical biosensors with the use of the MOFs as the sensing platforms because of the significant electro-chemistry features of the MOF. Moreover, MOFs are an attractive alternative as electrochemical biosensing materials due to higher mass transfer ability in the controlled porous structures [ 16 , 17 , 18 , 19 ]. Indeed, they carry the materials’ features and several beneficial features for electrochemical biosensor uses such as porous structures and higher specific surface areas.…”