Aim: To determine the effects of vitamin E therapy in the management of dyslipidemia with combination of statin drugs and also to determine the efficacy of statin drugs with combination of vitamin E therapy. Methodology: This case control study was conducted at LUMHS Jamshoro. Total 200 patients of dyslipidemia with the age between 30 to 50 years were included with mentioned inclusion and exclusion criteria & aere divided in to two groups; control group who received only statin drugs for treatment of dyslipidemia and case control group who received station drugs along with Vitamin E 800 mgs in divided dose.The fasting blood glucose level was measured by glucose oxidase method while lipid profile parameters serum cholesterol, TG’s, Serum LDL levels were estimated byenzyme caloric method on Cobas auto analyzer (model c-111 ACN 435 GERMANY) while HbA1c% was estimated on microlab. The statistical analysis was done on SPSS version 21 by applying unpaired student t test and ANOVA. The p value less than 0.05 consider as significant. Results: Finally after treatment phase the Mean & SD value of serum cholesterol in control group was 209.13 ± 5.15 mg/dl while in case study group was 189.51 ± 6.11 mg/dl , serum TG’s levels in control group was 191.52 ± 7.83 mg/dl & case study group was 168.56 ± 7.81 mg/dl, serum LDL levels in control group was 120.44 ± 4.67 mg/dl & in case study group was 97.15 ± 5.76 mg/dl. All parameters of lipid profile significantly decline in case study group. Conclusion: This research concluded that there is strong positive impact of vitamin E along with statin therapy on the management of dyslipidemia and in prevention of cardiovascular complications. Keywords: Dyslipidemia, Vitamin E, Statin Drugs.
Introduction: Diabetes mellitus and its complications are spreading with increased rate in Asian population especially in Pakistan. Uncontrolled diabetes can lead to different micro vascular complications. Cataract is one of the complications of diabetes which may lead to lens degenerative changes and visual impairment. G6PD plays a vital role in preventive measurements from cataract development in normal population. Objectives: This Study was designed to estimate G6PD levels in diabetic without ocular manifestations & diabetic cataract population. Methodology: This cross sectional comparative study was done at the Department of Biochemistry LUMHS Jamshoro in collaboration with the Diabetic clinic, Institute of Ophthalmology & Diagnostic Research Laboratory LUMHS Jamshoro. 100 diagnosed subjects of diabetes were selected by Non-Probability type of sample technique with consent of subjects and they were divided in to two groups Group A as control 50 diabetic subjects with out ocular manifestation while Group B as case study group contain 50 subjects of diabetes with cataract. The fasting blood glucose level was estimated by Hexokinase Method while G6PD level was measured by kit method on SD Biosensor while HbA1c(% ) was estimated by TTAB methodology. The data was statistically analyzed by SPSS 21. Results: The mean level of G6PD in Group A was 15.63±2.45 u/Hb while in group B it was 9.01±3.11 u/G HB. This result finally concluded that there was significantly (<0.05) decline of G6PD diabetic cataract as compared with diabetic without cataract. Conclusion: This study concluded that there was significant decline in G6PD level in diabetic cataract. It is also concluded that the estimation of G6PD level in diabetic population will be beneficial to take early preventive measurements against diabetic vascular complications.
Background: Diabetes Mellitus is one of the alarming health hazardous indicator and with poor glycemic control, it will be dangerous for human health because it is more prone to development of different systemic & vascular complications. G6PD is one of the carbohydrate metabolic enzyme which prevent from oxidative stress and development of free radicals. Objective: The purpose of this research is to evaluate the level of G6PD in patients of type-2 diabetes mellitus with their different levels of glycemic control index. Methodology: This study was done at Department of Biochemistry LUMHS in collaboration with Diabetic clinic LUMHS and Diagnostic & Research Laboratory LUMHS Jamshoro. Total 100 diagnosed cases of type-2 diabetes were selected and divided into three groups with different categories of glycemic control index. The HbA1c% was measured by Bio Red Variant while G6PD was measured by standard G6PD quantitative measurement method at Diagnostic laboratory LUMHS using assay kit (SD Biosensor, Inc. Republic of Korea). Results: The G6PD significantly (p < 0.05) decline in diabetic patients with poor glycemic control having mean values of HbA1c% between 11-13%. Conclusion: This research study concluded that there is significant decline in G6PD in patients of diabetes mellitus with poor glycemic control. Estimation G6PD also can use as screening test in diabetic population to determine their genetic involvement. Keywords: Type-2 Diabetes Mellitus, HbA1c%, G6PD
Background: Diabetes Mellitus is one of the alarming health hazardous indicator and with poor glycemic control it will be dangerous for human health because more prone to development of different systemic & vascular complications. G6PD is one of the carbohydrate metabolic enzyme which prevent from oxidative stress and development of free radicals. Objective: The purpose of this research to evaluate the level of G6PD in patients of type-2 diabetes mellitus with their different levels of glycemic control index. Methodology: This study was done at Department of Biochemistry LUMHS with collaboration of Diabetic clinic LUMHS and Diagnostic & Research Laboratory LUMHS Jamshoro. Total 100 diagnosed cases of type-2 diabetes were selected and divided into three groups with different categories of glycemic control index. The HbA1c% was measured by Bio Red Variant while G6PD was measured by standard G6PD quantitative measurement method at Diagnostic laboratory LUMHS using assay kit (SD Biosensor, Inc. Republic of Korea). Results: The G6PD significantly (p < 0.05) decline in diabetic patients with poor glycemic control having mean values of HbA1c% between 11-13%. Conclusion: This research study concluded that there is significant decline in G6PD in patients of diabetes mellitus with poor glycemic control. Estimation G6PD also can use as screening test in diabetic population to determine their genetic involvement. Keywords: Type-2 Diabetes Mellitus, HbA1c%, G6PD
Hypertension is one of the leading health hazards which increases cardiovascular mortality and morbidity all over the world. Hyperuricemia associated with hypertension can cause the development of gout, especially in the female gender. Different antihypertensive drugs have different effects on serum uric acid levels. Aims & Objective: To compare the effects of beta blockers (metoprolol) and calcium channel blocker (amlodipine) on serum uric acid level I the patients of hypertension. Methodology: This study was conducted at the Medical OPD of Bhittai Dental & Medical College Mirpurkhas from July 2021 to December 2021. A total of 100 hypertensive patients were selected under inclusion and exclusion criteria and divided into two groups with equal numbers of patients. Group A patients used beta blockers (metoprolol) and group B patients used calcium channel blockers (amlodipine) for the treatment of hypertension for three months' duration. Serum uric acid was measured by the PAP uricase method before the start of treatment and after completion of the treatment research phase. Statistical analysis was done by SPSS version 22. Results: The mean serum uric acid level of male patients in group A was 7.4± 0.4 mg/dl and that of female patients in group A was 6.2± 0.1 mg/dl before the start of research. After three months of complete treatment phase, the mean serum uric acid level of male patients in group A was 7.1± 0.35 mg/dl and that of female patients in group A was 6.0 ± 0.31 mg/dl. The mean serum uric acid level of male patients in group B was 7.2± 0.38 mg/dl and that of female patients in group B was 6.1± 0.28 mg/dl before the start of research. After three months of the complete treatment phase, the mean serum uric acid level of male patients in group B was 7.0± 0.22 mg/dl and that of female patients in group B was 5.91± 0.27 mg/dl. There was no significant change in serum uric acid observed in either group under study. Conclusion: This study concluded that metoprolol (beta blocker) or amlodipine (calcium channel blocker) have no significant effect on serum uric acid levels in hypertensive patients. Keywords: Hypertension. Serum Uric Acid , Beta blockers, Calcium Channel blockers,
Background: Statin drugs are using all over the world for the treatment of hypercholesterolemia. There is hypothesis that post menopausal women who used statin drugs long time can develop the onset of type 2 diabetes mellitus because statin drugs inhibit the signal transduction of insulin by inhibiting oxidative phosphorylation resulting in decrease secretion of insulin leads to hyperglycemia. The aim of this study to estimate the effects of statin drugs on blood glucose level and HbA!c% in post menopausal women. Methodology: This case comparative study was done at LUMHS Jamshoro. The sampling was done by Non Probability method. Total number of150 subjects were divided in 2 group’s i.e group A (Control group) & group B (Case study group). The fasting glucose level was measured by glucose oxidase method while HbA1c% & serum cholesterol levels were determined by Kit method by using auto analyzer. The statistical analysis was done by SPSS 21 by applying ANOVA test for multiple variants. Results: The mean with S.D fasting blood glucose levels in control group was 78± 9.05 mg/dl while in case study group it was 134 ± 12.15mg/dl (p <0.05), HbA1c% levels in control group was 5.3 ± 1.1% while in case study group it was 7.4 ± 1.3% (p<0.05) and serum cholesterol in control group was 157± 9.75 mg/dl while in case study group it was 195 ± 8.78 mg/dl (p<0.05) was significantly (P<0.05). The glycemic index & fasting blood glucose levels significantly observed elevated in post menopausal women who were use statin drugs since last three years Conclusion: This study concluded that there was significant relation of statin drugs on increasing of blood glucose levels so they can induce the onset of Type-2 Diabetes Mellitus.
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