6017 Retrospective analysis of resected primary colorectal cancer reveled no correlation b/w node harvest and node involvement

Khan, Kamrul Hasan; Rathore, Mobeen H.; Loughlin, Virginia Hebe Mac; Tham, Tck; Bhatti, Muhammad Ishaque; Allen, Danny; Wilson, Robin

doi:10.1016/s1359-6349(09)71112-7

Cited by 2 publications

(1 citation statement)

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“…14,15 Harvesting ≥12 nodes can be considered a quality assurance tool. 16 On the other hand, a study found that increased number of lymph nodes examined after colectomy does not improve colon cancer staging but associated with a slight improvement in overall survival. 13 To date, several studies examined the prognostic role of harvesting higher numbers of lymph node using different cutoff values.…”

Section: Discussionmentioning

confidence: 98%

Higher cut-offs for the number of lymph nodes harvested do not predict better prognosis in patients with colon cancer

Güner

Tümay

2020

Journal of Coloproctology

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Background Current threshold for minimum lymph node harvest may not be adequate for appropriate staging in colon cancer and newer surgical techniques may allow more lymph nodes to be harvested. The aim of this study was to examine the prognostic role of harvesting and examining lymph nodes higher in number than the recommended threshold (≥12), in patients with colon cancer. Methods This retrospective study included 179 patients that underwent open colon resection for adenocarcinoma of the colon. A D3 resection with high vascular ligation was made so that large number of lymph nodes was removed in most patients. Differences in overall survival between below and above three cutoff points (≥18, ≥24, ≥40) were estimated. Results During median 33 months of follow-up, 45 patients died and mean overall survival was 108.7 ± 5.6 months (95% CI, 97.7–119.7). The mean number of lymph nodes harvested and examined was 44.0 ± 25.7 (median 38; range, 7–150). No significant effect was found for three different cut-off values (≥18, ≥24, or ≥40 nodes) on mean overall survival (p > 0.05 for all comparisons). The same was true for the whole study population as well as for N0 (N negative) and N1-2 (N positive) patient subgroups, when they are analyzed separately. Conclusions Our findings do not support the survival benefit of substantially higher number of lymph nodes harvested in colon cancer.

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Section: Discussionmentioning

confidence: 98%

Higher cut-offs for the number of lymph nodes harvested do not predict better prognosis in patients with colon cancer

Güner

Tümay

2020

Journal of Coloproctology

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Blood CEA levels for detecting recurrent colorectal cancer

Nicholson

Shinkins

Pathiraja

et al. 2015

Cochrane Database of Systematic Reviews

153

149

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CEA is insufficiently sensitive to be used alone, even with a low threshold. It is therefore essential to augment CEA monitoring with another diagnostic modality in order to avoid missed cases. Trying to improve sensitivity by adopting a low threshold is a poor strategy because of the high numbers of false alarms generated. We therefore recommend monitoring for colorectal cancer recurrence with more than one diagnostic modality but applying the highest CEA cut-off assessed (10 µg/L).

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6017 Retrospective analysis of resected primary colorectal cancer reveled no correlation b/w node harvest and node involvement

Cited by 2 publications

References 0 publications

Higher cut-offs for the number of lymph nodes harvested do not predict better prognosis in patients with colon cancer

Higher cut-offs for the number of lymph nodes harvested do not predict better prognosis in patients with colon cancer

Blood CEA levels for detecting recurrent colorectal cancer

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