The study was carried out in order to assess the impact of the various pollutants of textile dyeing effluents on the surface water quality of the industrial area inside Dhaka-Narayanganj-Demra (D.N.D) embankment, Narayanganj. Physicochemical parameters such as TSS, TDS, DO, pH, EC, Turbidity, BOD, COD, anionic parameters such as F -, Cl -, NO 2 -, NO 3 -, SO 4 -and PO 4 3-and heavy metals such as Pb, Zn, Cd and Cu of the samples were investigated by using various techniques. The results showed that, textile dyeing industries inside D.N.D embankment area discharges effluents composed of various physicochemical and anionic pollutants at considerably higher level compared to pollution limit.Further, the surface water of the D.N.D channel, ponds and lakes around the studied textile dyeing industries also contain various physicochemical and anionic pollutants at intolerable limit. A significant correlation was also observed among some important water parameters of the effluents and surface water. The above findings point out that the surface water around the studied textile dyeing industries is highly polluted by the industrial activities of the D.N.D. embankment area and not good for human consumption.

The current study was designed to isolate and characterize some bioactive secondary metabolites by using repeated chromatographic and spectroscopic techniques, targeting their anticancer, antimicrobial, and antioxidant properties through in vitro and in silico approaches. Six compounds were isolated and analyzed by thin layer chromatographic technique and the compounds were identified as 5- O -caffeoyl quinic acid ( 1 ), syringin ( 2 ), luteolin ( 3 ), apigenin ( 4 ), jhanol ( 5 ), and jhanidiol ( 6 ) based on spectroscopic methods. The cytotoxic effect of each compound was dose-dependent, and compound 1 showed a higher anti-proliferative effect (IC 50 = 181.3 μg/ml) than other compounds (compound 2 , 4 , 5 , and 6 ). Besides, compound 1 showed the most promising antibacterial activity with a zone of inhibition ranges from 12–15 mm against different strains compared to ciprofloxacin (14–22 mm). In contrast, compound 3 exerted the highest scavenging property against DPPH free radical. Finally, the in vitro bioactivities were also supported by molecular docking studies. The computational study demonstrated that the isolated compounds exerted stronger affinity compared to the standard drugs towards the binding sites of dihydrofolate reductase (DHFR), glutathione reductase, and urase oxidase.

The main source of irrigation water in Bangladesh is groundwater, hence its quality needs

Background The present study evaluated the antinociceptive effect of the bark of Artocarpus lacucha , which is used for the treatment of stomachache, headache and boils in the traditional system of medicine. Methods The antinociceptive activity was investigated by the tail immersion, hot plate, acetic acid- & formalin-induced nociception and carrageenan-induced paw edema tests using a hydro-methanolic extract of A. lacucha bark. The plant extract was found to contain a substantial amount of phenolic compounds according to the total phenolic and flavonoid content assay. A phenolic metabolite, (+)-catechin, has been isolated using different chromatographic techniques. The compound was characterized with 1D and 2D NMR spectroscopic data. (+)-catechin, isolated from A. lacucha was assessed for antinociceptive effects swiss albino mice. Furthermore, the possible involvement of opioid receptors and ATP-sensitive K + channel for the effect of the plant extract and (+)-catechin has been justified using naloxone and glibenclamide, respectively. Results Oral administration (p.o) of the plant extract (50–200 mg/Kg b.w.) resulted in significant thermal pain protection in the hot plate and tail immersion tests. The action of the plant extract was significantly antagonized by naloxone, a non-selective opioid antagonist, in the hot plate and tail immersion tests, which supports the involvement of opioid receptors. Both the plant extract and (+)-catechin, (50–200 mg/Kg b.w., p.o.) significantly diminished the acetic acid- & formalin-induced nociception, and carrageenan-induced paw edema. Glibenclamide, an ATP-sensitive K + channel blocker, significantly reversed their effect in the acetic acid-induced writhing test which indicates the participation of ATP-sensitive K + channel system. Conclusions The investigation revealed potential central and peripheral antinociceptive effects of A. lacucha bark supports its applications in the traditional system of medicine. Electronic supplementary material The online version of this article (10.1186/s12906-019-2565-x) contains supplementary material, which is available to authorized users.

With the aid of Injection Moulding Machine (IMM) Palm fiber reinforced Acrylonitrile Butadiene Styrene (ABS) composites (PF-ABS) were prepared. Three sets of samples were prepared for three different wt% (5%, 10% and 20%) of fiber contents. Scanning Electron Microscopy (SEM), X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) experiments were performed to study the surface morphology, microstructure (if it crystalline or noncrystalline) and new bond formation after preparation of the composites. SEM pattern shows that after addition of palm fiber in PF-ABS composites the brittleness increased due to creation of voids in the composites except 10% fiber content in PF-ABS. From XRD pattern it is clear that the palm fiber, ABS and PF-ABS composites are amorphous in nature. Moreover FTIR spectrum shows that there is no new bond formed after addition of palm fiber in ABS polymeric matrix to create PF-ABS composites.

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Wendlandia tinctoria var. grandis (Roxb.) DC. (Family: Rubiaceae) is a semi-evergreen shrub distributed over tropical and subtropical Asia. The present research intended to explore the pharmacological potential of the stem extract of W. tinctoria, focusing on the antioxidant, hypoglycemic, and antidiarrheal properties, and to isolate various secondary metabolites as mediators of such activities. A total of eight phenolic compounds were isolated from the dichloromethane soluble fraction of the stem extract of this plant, which were characterized by electrospray ionization (ESI) mass spectrometric and 1H NMR spectroscopic data as liquiritigenin (1), naringenin (2), apigenin (3), kaempferol (4), glabridin (5), ferulic acid (6), 4-hydroxybenzoic acid (7), and 4-hydroxybenzaldehyde (8). The dichloromethane soluble fraction exhibited the highest phenolic content (289.87 ± 0.47 mg of GAE/g of dried extract) and the highest scavenging activity (IC50 = 18.83 ± 0.07 µg/mL) against the DPPH free radical. All of the isolated compounds, except 4-hydroxybenzaldehyde, exerted a higher antioxidant effect (IC50 = 6.20 ± 0.10 to 16.11 ± 0.02 μg/mL) than the standard butylated hydroxytoluene (BHT) (IC50 = 17.09 ± 0.01 μg/mL). Significant hypoglycemic and antidiarrheal activities of the methanolic crude extract at both doses (200 mg/kg bw and 400 mg/kg bw) were observed in a time-dependent manner. Furthermore, the computational modeling study supported the current in vitro and in vivo findings, and the isolated constituents had a higher or comparable binding affinity for glutathione reductase and urase oxidase enzymes, glucose transporter 3 (GLUT 3), and kappa-opioid receptor, inferring potential antioxidant, hypoglycemic, and antidiarrheal properties, respectively. This is the first report of all of these phenolic compounds being isolated from this plant species and even the first demonstration of the plant stem extract's antioxidant, hypoglycemic, and antidiarrheal potentials. According to the current findings, the W. tinctoria stem could be a potential natural remedy for treating oxidative stress, hyperglycemia, and diarrhea. Nevertheless, further extensive investigation is crucial for thorough phytochemical screening and determining the precise mechanisms of action of the plant-derived bioactive metabolites against broad-spectrum molecular targets.

Hydrochemistry in parts of the Lower Tista Floodplain in northwest Bangladesh is dominated by alkalies and weakly acid, having highest concentration of sodium cations and bicarbonate anions respectively. Groundwater is characterized by sodium-calcium and sodium-potassium cation and bicarbonate-chloride-sulphate anion facies, and genetically 'normal chloride', 'normal sulphate', and 'normal carbonated' type, and soft to saline. Based on electrical conductivity values, the area is divided into northern fresh and southern saline groundwater zone, and values like salinity, Na%, SAR, and RSC and a good correlation between Na + and Cl -, and Cl -and salinity reveals increasing salinity with depth indicating a mixing of fresh and saline bodies due to marine transgression (?) during Holocene period in the Bengal delta. The rock weathering is likely to affect the groundwater quality by dolomite dissolution and calcium precipitation, representing reverse softening process and is brine seawater. Water extracted from shallow zone (from 20 to 30 m) has suitability for drinking purpose, livestock consumption and irrigation purposes, and partially suitable for industrial use, but that from deeper zone (from 30 to 50 m) is generally poor and unsuitable especially for irrigation purposes with low alkali and moderate to high salinity hazard. So groundwater can be used for irrigation in the area of fine textured soil with proper management practices.