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The leaf essential oil of Laurus nobilis Linn. (Lauraceae) has been evaluated for antinociceptive and anti-inflammatory activities in mice and rats. The essential oil exhibited: (1) a significant analgesic effect in tail-flick and formalin tests; (2) a dose-dependent anti-inflammatory effect in the formalin-induced edema and (3) a moderate sedative effect at the anti-inflammatory doses. The analgesic and anti-inflammatory effect of the essential oil was comparable to reference analgesics and non-steroid anti-inflammatory drugs: morphine and piroxicam. Present results make the essential oil worthy of further investigations.

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Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats

Ahmadiani¹,

Fereidoni²,

Semnanian³

et al. 1998

Journal of Ethnopharmacology

107

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