Comparison of the Free Radical Scavenging Activity of Six Iranian<i>Achillea</i>. Species

Nickavar, Bahman; Kamalinejad, Mohammad; Haj-Yahya, Maher; Shafaghi, Bijan

doi:10.1080/13880200600686590

Cited by 78 publications

(74 citation statements)

References 23 publications

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“…This lack of relationship is in agreement with other literature [28]. It is known that only flavonoids with a certain structure and particularly hydroxyl position in the molecule can act as proton donating and show radical scavenging activity [29,30]. Furthermore, the extracts are very complex mixtures of many different compounds with distinct activities.…”

Section: Relationship Between Total Phenolic Content and Antioxidant supporting

confidence: 77%

Study of Total Phenolic and Flavonoid Content, Antioxidant Activity and Antimicrobial Properties of Medicinal Plants

Kaur¹

2014

JMEN

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The anti-oxidant activity and total phenolic content of alcoholic extracts from seven medicinal plants (Asparagus racemosus, Ocimum sanctum, Cassia fistula, Piper betel, Citrus aurantifolia, Catharanthus roseus, and Polyalthia longifolia) were evaluated by using a model system consisting of β-carotene, DPPH free radical and Folin-Ciocalteu method. The total Phenolic content of the extracts was determined spectrophotometrically according to the Folin-Ciocalteu procedure and ranged from 366mg/100g to 212 mg/100g on fresh weight basis. The total flavanoid content of extracts determined by Aluminium chloride colorimetric assay and ranged from 39.84mg/100g to 15.94mg/100g of fresh weight. The highest antioxidant activity was demonstrated by Citrus auantifolia (87.05%) followed by Ocimum sanctum (81.80%) and Catharanthus roseus (71.4%). The highest tannin content was found to be in Catharanthus roseus (7.14%) while in case of anthocyanin content the highest value was found to be in Polyalthia longifolia (0.65mg/l). As far as antimicrobial activity is concerned, Ocimum sanctum and Citrus aurantifolia were found to be most potent against Escherichia coli and Staphylococcus aureus whereas Piper betel showed no effect. Except Piper betel all the extracts were able to inhibit the two bacterial strains and the zone of inhibitions ranged from 19.6 mm to 13.5 mm. The minimum inhibitory concentration against E. coli in case of Ocimum sanctum is 10% and against S. aureus it is 20% while in case of Citrus aurantifolia extracts were active even at 10% concentration for E. coli and 15% for S. aureus.

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Section: Relationship Between Total Phenolic Content and Antioxidant supporting

confidence: 77%

Study of Total Phenolic and Flavonoid Content, Antioxidant Activity and Antimicrobial Properties of Medicinal Plants

Kaur¹

2014

JMEN

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“…The antioxidant activity of extracts could therefore not only be explained on the basis of their phenolic content, but required also their proper characterization. It is known that only flavonoids with a certain structure and particularly hydroxyl position in the molecule can act as proton donating and show radical scavenging activity (Nickavar et al, 2007;Wojdylo et al, 2007). Furthermore, the extracts are very complex mixtures of many different compounds with distinct activities.…”

Section: Mesozygia E Magaliesmontanum L Leucocephala and L Jamentioning

confidence: 99%

Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa

Dzoyem¹,

Eloff²

2015

Journal of Ethnopharmacology

127

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Ethnopharmacological relevanceOxidative stress and inflammatory conditions are among the pathological features associated with the central nervous system in Alzheimer's disease. Traditionally, medicinal plants have been used to alleviate inflammation, pains and also other symptoms possibly associated with Alzheimer's disease. Therefore, the present study was designed to determine the in vitro antiinflammatory, antioxidant and anticholinesterase activity of twelve South African medicinal plants traditionally used to alleviate pain and inflammation. Materials and MethodsNitric oxide (NO) production in LPS-activated RAW 264.7 macrophages and 15-lipoxygenase (LOX) inhibitory assay were used to evaluate the anti-inflammatory activity.Acetylcholinesterase inhibition was assessed by using a modification of the Ellman's method.Antioxidant activity, total phenolic and total flavonoids contents were determined using standard in vitro methods. ResultsThe extract of Burkea africana had the highest anti-15-lipoxygenase activity with 85.92% inhibition at 100 µg/mL. All the extracts tested inhibited nitric oxide (NO) production in a dose dependant manner in LPS-stimulated RAW 264.7 macrophages. However, extracts from Leucaena leucocephala, Lippia javanica inhibited the production of NO by 97% at a concentration of 25 µg/mL. In addition, both Leucaena leucocephala and Englerophytum magaliesmontanum had strong activity against acetylcholinesterase with IC 50 values of 118 µg/mL and 160 µg/mL respectively. Hight levels of phenolics and flavonoids were found in Leucaena leucocephala, Lippia javanica and Burkea africana. The correlation with antioxidant activities was not strong indicating that other metabolites may also be involved in antioxidant activity. ConclusionsThe results obtained in this study validate the use of leaf extracts of these plants in South African traditional medicine against inflammation. Extracts of these plants species might be of value in the management of various diseases emerging from oxidative stress and related degenerative disorders.2

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“…The compounds 8 (14),15-sandaracopimaradiene-2α,18-diol, a diterpenod with antimicrobial activity [5], 5,6-dehydro-α-pyrone (umuravumbolide) [10] and tetradenolide α-pyrone [5] have also been isolated. Although there is broad report on the isolated compounds of T. riparia essential oil, our group still searches for minor constituents that represent a great challenge for researchers.…”

Section: Introductionmentioning

confidence: 99%

“…From the essential oil of T. riparia, Zelnik et al [6] isolated ibozol and 7α-hydroxyroyleanone, Van Puyvelde et al [4,9] isolated diterpenediol 8 (14),15-sandaracopimaradiene-7α,18-diol, and 1',2'-dideacetylboronolide. The compounds 8 (14),15-sandaracopimaradiene-2α,18-diol, a diterpenod with antimicrobial activity [5], 5,6-dehydro-α-pyrone (umuravumbolide) [10] and tetradenolide α-pyrone [5] have also been isolated.…”

Section: Introductionmentioning

confidence: 99%

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New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities

et al. 2014

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Tetradenia riparia (Hochstetter) Codd belongs to the Lamiaceae family and it was introduced in Brazil as an exotic ornamental plant. A previous study showed its antimicrobial, acaricidal and analgesic activities. Two compounds were isolated from essential oil of T. riparia leaves and identified as 9β,13β-epoxy-7-abietene (1), a new one, OPEN ACCESSMolecules 2014, 19 515 and 6,7-dehydroroyleanone (2), already reported for another plant. The structure of these compounds was determined by spectroscopic analysis and by comparison with literature data. The cytotoxic activities of the essential oil and compounds 1 and 2 were determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and by tumor cells MDA-MB-435 (human breast carcinoma), HCT-8 (human colon), SF-295 (human nervous system) and HL-60 (human promyelocytic leukemia). The essential oil and compound 1 showed high cytotoxic potential of the cell lines SF-295 (78.06% and 94.80%, respectively), HCT-8 (85.00% and 86.54%, respectively) and MDA-MB-435 (59.48% and 45.43%, respectively). Compound 2 had no cytotoxic activity. The antioxidant activity was determined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH), β-carotene-linoleic acid system and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The inhibitory concentration (IC 50 in µg mL −1 ) for essential oil and compound 2 was, respectively 15.63 and 0.01 for DPPH; 130.1 and 109.6 for β-carotenelinoleic acid and 1524 and 1024 for ABTS. Compound 1 had no antioxidant activity. By fractioning the oil, it was possible to identify two unpublished compounds: 1 with high cytotoxic potential and 2 with high antioxidant potential.

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Comparison of the Free Radical Scavenging Activity of Six IranianAchillea. Species

Cited by 78 publications

References 23 publications

Study of Total Phenolic and Flavonoid Content, Antioxidant Activity and Antimicrobial Properties of Medicinal Plants

Study of Total Phenolic and Flavonoid Content, Antioxidant Activity and Antimicrobial Properties of Medicinal Plants

Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa

New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities

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