Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil

Sayyah, Mohammad; Nadjafnia, Leila; Kamalinejad, Mohammad

doi:10.1016/j.jep.2004.05.021

Cited by 129 publications

(90 citation statements)

References 22 publications

(26 reference statements)

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“…At anticonvulsant doses, cineol, α-pinene and β-pinene produced sedation and motor impairment (Sayyah et al, 2004). Intraperitoneal administration of 1,8-cineol and caryophyllene significantly increased ambulatory activity in mice, suggesting that these chemicals possess pharmacological actions on behavior (Umezu et al, 2001).…”

Section: Biological Activity Of Essential Oils Found In This Analysismentioning

confidence: 97%

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Negri¹,

Rodrigues²

2010

Rev. bras. farmacogn.

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RESUMO: "Óleos essenciais encontrados na fumaça do ¨tira-capeta¨, um cigarro utilizado pelos quilombolas que vivem no pantanal do Brasil". Pesquisa etnofarmacológica realizada entre os quilombolas que vivem na Sesmaria Mata-Cavalos, no Estado de Mato Grosso, Brasil, um cigarro conhecido como ¨tira-capeta¨, foi citado por melhorar a memória e cognição, além de possuir outras indicações terapêuticas, tais como, "contra a sinusite", "para evitar resfriado", e "para aliviar problemas de insônia". No presente estudo, foi feita a caracterização dos óleos essenciais liberados durante o aquecimento das plantas utilizadas na confecção do cigarro, usando um método simples, rápido e livre de solvente baseado em cromatografia gasosa acoplada a espectrometria de massas usando "headspace" e microextração em fase sólida. Os principais constituintes encontrados foram 1,8-cineol, cânfora e α-pineno. Na tentativa de correlacionar a atividade biológica desses constituintes com as indicações terapêuticas relatadas pelos quilombolas, encontramos vários trabalhos realizados por diversos autores que mostraram que estes óleos possuem atividades similares às indicações terapêuticas relatadas pelos quilombolas.Unitermos: Etnofarmacologia, óleos essenciais, medicina popular, sistema nervoso central, quilombolas, memória. ABSTRACT: An ethnopharmacological survey developed among quilombolas living in SesmariaMata-Cavalos, in the State of Mato Grosso, Brazil; a cigarette known as "tira-capeta" (removingthe-devil), had been cited mainly "to improve memory and cognition", and also showed other therapeutical indications, such as: "against sinusitis", "to avoid cold", "to relieve sleep problems". The purpose of the present study was carried out a screening of essential oils delivered in the heating of plants used to produce the "tira-capeta" cigarette, using a simple, rapid and solvent-free method based on gas chromatography-mass spectrometry and headspace solid-phase microextraction. The principal essential oils found were 1,8 cineole, camphor and α-pinene. In the tentative to correlate these constituents with therapeutical indications reported by the quilombolas, were found some works carried out by many authors that corroborated the therapeutical indications reported by the quilombolas.

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Section: Biological Activity Of Essential Oils Found In This Analysismentioning

confidence: 97%

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Negri¹,

Rodrigues²

2010

Rev. bras. farmacogn.

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“…Some specific studies show that β-pinenes, along with α-pinenes and other terpenes, are cytotoxic on cancer cells [55]. They represent a great part of essential oils with sedative properties [66]. When α-and β-pinenes are the major constituents of an essential oil, they warrant the anti-inflammatory and analgesic activity [67].…”

Section: R E V I E W P a P E R S Ijomeh 2009;22(4) 335mentioning

confidence: 99%

The essential oil of turpentine and its major volatile fraction (α- and β-pinenes): a review

Mercier¹,

Prost²,

Prost³

2009

International Journal of Occupational Medicine and Environmental Health

141

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This paper provides a summary review of the major biological features concerning the essential oil of turpentine, its origin and use in traditional and modern medicine. More precisely, the safety of this volatile fraction to human health, and the medical, biological and environmental effects of the two major compounds of this fraction (α-and β-pinenes) have been discussed. Key words:Spirits of turpentine, α-pinene, β-pinene Received: July 1, 2009. Accepted : September 28, 2009. Address reprint request to B. Mercier, UPRES EA 4183 "Lipides & Signalisation Cellulaire", Faculté des Sciences de la Vie, Université de Bourgogne 6, Boulevard Gabriel, F-21000 Dijon (e-mail: beamercier@laposte.net). ORIGIN OF TURPENTINEThe term "essential oil of turpentine" designates the terpenic oil, obtained by hydrodistillation of the gem pine. It is also named the "spirits of turpentine", "pine tree terpenic", "pine oleoresin", "gum turpentine", "terpenes oil" or "turpentine from Bordeaux". Due to its pleasant fragrance, the terpenic oil is used in the pharmaceutical industry, perfume industry, food additives and other chemical industries (household cleaning products, paintings, varnishes, rubber, insecticides, etc.) [1]. TRADITIONAL MEDICINE AND TURPENTINEThe eminent doctors of antiquity, Hippocrates, Dioscoride or Galien, used the terpenic oil for its properties against lung diseases and biliary lithiasis. In France, Thillenius, Pitcairn, Récamier and Martinet recommended it against the blennorrhoea and cystitis. Chaumeton, Peschiez, Kennedi, Mérat prescribed it against the neuralgias. It was also used in the treatment of rheumatism, sciatica, nephritis, drop, constipation and mercury salivation. Those scientists also recognized that the terpenic oil may be a booster at an average dose and may have a paralyzing activity at high doses. In Germany, (Rowachol and Rowatinex), Slovenia (Uroterp) and Poland (Terpichol and Terpinex), the traditional drugs for renal and hepatic diseases (especially against cholesterol stones in the gall bladder and the bile duct) contain α-and β-pinenes [2]. Modern phytotherapy describes the following properties of the terpenic oil: antiparasitic, analgesic, revulsive, disinfectant (external use); balsamic, active on bronchial secretion and pulmonary and genito-urinary tract infections, haemostatic, dissolving gallstones, diuretic, antispasmodic, antirheumatic, deworming, being an antidote for poisonings caused by phosphorus [3] and improving the ciliary and secretory activity in patients who present chronic obstructive bronchitis (internal use ) [4]. ENVIRONMENTAL IMPACT OF THE VOLATILE TURPENTINE FRACTIONThe most volatile components of turpentine are two terpenes: alpha (α) and beta (β) pinenes. They are the dominant odorous compounds emitted by trees, shrubs, flowers and grasses [25]. In the lower troposphere, and depending on the weather conditions at the top of the trees, these compounds can react with OH° radicals, ozone, NO 3 radical and O 2 . Indeed, the electric field in the canopy at...

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“…The plant yielded 4% (v/w) essential oil. The essential oil was kept protected from light at 4°C (Sayyah et al, 2004). The final concentrations of 0.1% and 0.005%, required to influence the neuronal excitability for Tarragon extract and its essential oil, respectively, were chosen on the basis of the preliminary experiments.…”

Section: Isolation Of the Essential Oilmentioning

confidence: 99%

“…It was suggested that some of the essential oils (e.g. anise) containing monoterpenoids especially trans-anethole exert anticonvulsant activity (Sayyah et al, 2004). Pimpinella anisum is another aromatic herb which contains anethole as its main constituent.…”

mentioning

confidence: 99%

Medicinal Herbs and Epilepsy: A Two Edged Sword

Janahmadi¹,

Farajnia²,

Ghasemi³

et al. 2011

Underlying Mechanisms of Epilepsy

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Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil

Cited by 129 publications

References 22 publications

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

Essential oils found in the smoke of "tira-capeta", a cigarette used by some quilombolas living in pantanal wetlands of Brazil

The essential oil of turpentine and its major volatile fraction (α- and β-pinenes): a review

Medicinal Herbs and Epilepsy: A Two Edged Sword

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