No abstract

Typical applications of solvent-free conditions and microwave activation are described. Non-purely thermal specific effects are evidenced and discussed in terms of reaction medium and mechanisms, taking into account the variations in polarity of the systems.

A series of typical solvent-free reactions have been safely and beneficially scaled-up to several hundred grams in a larger batch reactor (Synthewave 1000) with yields equivalent to those obtained under similar conditions (temperature, reaction time) in laboratory-scale experiments (Synthewave 402). They concern potassium acetate alkylation, regioselective phenacylation of 1,2,4-triazole, deethylation of 2-ethoxy-anisole, and typical examples in carbohydrate chemistry (peracetylation, glycosylation, saponification, halogenation, and epoxidation of Dglucopyranosides).

No abstract

N-Alkylation N-Alkylation O 0268Clean and Efficient Microwave-Solvent-Free Synthesis of 1-(2',4'-Dichlorophenacyl) Azoles. -Microwave-assisted N-alkylation of various azoles with dichlorophenacyl chloride (II) is shown to take place smoothly to furnish the N(1)-alkylated analogues with high regioselectivity. Thermal and microwave effects of this reaction are studied in detail using related reactions under thermal conditions and in the presence of solvents. -(PEREZ, E. R.; LOUPY*, A.; LIAGRE, M.; DE GUZZI PLEPIS, A. M.; CORDEIRO, P. J.; Tetrahedron 59 (2003) 6, 865-870; Lab. React. Sel. Supports, CNRS, Inst. Chim. Mol. Orsay, Univ. Paris-Sud, F-91405 Orsay, Fr.; Eng.) -Mischke 21-059

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.