A series of typical solvent-free reactions have been safely and beneficially scaled-up to several hundred grams in a larger batch reactor (Synthewave 1000) with yields equivalent to those obtained under similar conditions (temperature, reaction time) in laboratory-scale experiments (Synthewave 402). They concern potassium acetate alkylation, regioselective phenacylation of 1,2,4-triazole, deethylation of 2-ethoxy-anisole, and typical examples in carbohydrate chemistry (peracetylation, glycosylation, saponification, halogenation, and epoxidation of Dglucopyranosides).

The ability of D‐6‐deoxy‐myo‐inositol 1,4,5‐trisphosphate [6‐deoxy‐Ins(1,4,5)P3], a synthetic analogue of the second messenger D‐myo‐inositol 1,4,5‐trisphosphate [Ins(1,4,5)P3], to mobilise intracellular Ca2+ stores in permeabilised SH‐SY5Y neuroblastoma cells was investigated. 6‐Deoxy‐Ins(1,4,5)P3 was a full agonist (EC30 = 6.4 μM), but was some 70‐fold less potent than Ins (1,4,5)P3 (EC30 = 0.09 μM), indicating that the 6‐hydroxyl group of Ins(1,4,5)P3 is most important for receptor binding and stimulation of Ca2+ release, but is not an essential structural feature. 6‐Deoxy‐Ins(1,4,5)P3 was not a substrate for Ins (1,4,5)P3 5‐Phosphatase, but inhibited both the hydrolysis of 5‐[22P] + Ins (1,4,5)P3 (K 1 76 μM) and the phosphorylation of [3H]Ins(1,4,5)P3 (apparent K 1 5.7 μM) 6‐Deoxy‐Ins (1,4,5)P3 mobilized Ca2+ with different kinetics to Ins(1,4,5)P3, indicating that it is probably a substrate for Ins(1,4,5)P3 3‐kinase.