High-dose immunosuppression and AHST were performed with acceptable toxicity in a small number of patients with newly diagnosed type 1 DM. With AHST, beta cell function was increased in all but 1 patient and induced prolonged insulin independence in the majority of the patients.
In comparison to international literature, our results, showed intermediated total cholesterol, lower LDL-cholesterol and non-HDL-cholesterol and higher HDL-cholesterol. Therefore, primary prevention programs are needed to be carrying out, especially among overweight children and adolescents so to prevent ischemic heart disease as adulthood.
Classe I: evidência ou concordância geral de que o tratamento é benéfico, útil e eficaz.Classe II: evidência conflitante e/ou divergência de opinião quanto à utilidade e à eficácia do tratamento.Classe IIa: forças das evidências/opiniões em favor da utilidade e da eficácia.Classe IIb: forças das evidências/opiniões menos bem estabelecidas quanto à utilidade e à eficácia.Classe III: evidência ou concordância geral de que o tratamento não é útil/eficaz e em alguns casos pode ser prejudicial.
Nível de evidência A: presença de múltiplos estudos clínicos randomizados.Nível de evidência B: presença de um único estudo clínico randomizado ou de estudos não-randomizados.Nível de evidência C: consenso de especialistas.O nível de evidência será apresentado apenas para os tratamentos do infarto do miocárdio, não se aplicando aos procedimentos diagnósticos. Todos os métodos complementares deverão ser realizados por profissionais experientes, segundo as recomendações específicas de cada especialidade.
O objetivo deste estudo foi estimar a prevalência, o conhecimento, o tratamento e o controle de hipertensão arterial sistêmica (HAS) na população urbana adulta de Tubarão, Santa Catarina, Brasil. Foi realizado um estudo transversal, com uma amostra estratificada a partir de uma listagem dos pontos de luz, do qual participaram 707 indivíduos maiores de 18 anos. Foi aplicado um questionário, aferidas duas medidas da pressão arterial por manômetro de mercúrio, em uma visita domiciliar conduzida por estudantes de medicina. A prevalência de HAS pelo critério do The Seventh Report of The Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (pressão arterial > 140 x 90mmHg) foi de 36,4% e de 40,5% quando acrescentados os indivíduos em uso de anti-hipertensivos. Tinham conhecimento da hipertensão 55,6%; estavam em tratamento farmacológico 46,8% e estavam com a pressão arterial controlada 10,1% dos hipertensos. A elevada prevalência estimada de hipertensão arterial e os percentuais de conhecimento sobre o diagnóstico, tratamento e controle aquém do ideal apontam para necessidade de ações preventivas em Tubarão.
The analysis of the main outcomes in this study did not demonstrate a significant advantage of anodal tDCS applied to M1 in patients with human T-lymphotropic virus type I and chronic pain in comparison with sham tDCS, although secondary analysis suggests some superiority of active tDCS over sham. The large placebo effect observed in this study may explain the small differences between sham versus active tDCS.
This review summarizes the results of several pharmacological interventions that have been evaluated in the management of acute myocardial infarction. Of these, thrombolytic therapy, aspirin, beta-blockers and angiotensin converting enzyme inhibitors have all been proven to reduce mortality risk and the latter three classes of drugs have also been shown to reduce morbidity. Routine use of heparin or nitrates is not recommended although they may be useful in specific circumstances such as post-infarction angina or large infarcts. Drugs that have as yet not been shown to have a role in the routine management of acute myocardial infarction include Class I antiarrhythmic agents, magnesium and calcium antagonists. Management of patients with acute myocardial infarction can now be appropriately based on the evidence generated from well conducted randomized clinical trials and appropriate therapeutic choices based on such information can be expected to reduce their morbidity and mortality risks.
The observation of a close relationship of heart rate to oxygen uptake (HR-VO2) and heart rate to minute ventilation (HR-VE) has been shown to be of particular value in rate variable pacing. However, the impact of anaerobic threshold (AT) for the HR-VO2 and HR-VE slope has been studied less. Twenty-three male and 16 female subjects, mean age 52 +/- 7 years, were selected in whom complete heart catherization and extensive noninvasive studies excluded major cardiopulmonary disease. Semisupine bicycle exercise testing with analysis of respiratory gas exchange was performed using a ramping work rate protocol with work increments of 20 watts/min. At the respiratory AT, determined by the V slope method, oxygen uptake (VO2-AT) was 15.2 +/- 3.0 mL/kg in males versus 13.8 +/- 2.3 mL/kg in females and heart rate (HR-AT) was 109 +/- 18 beats/min versus 119 +/- 20 beats/min, respectively. Heart rate was highly correlated (r > or = 0.9) to VO2 and minute ventilation (VE). A linear regression for HR-VO2, however, was found only in 16/39 and for HR-VE in 11/39 subjects. Assuming the AT as the breakpoint of two linear curves, it could be demonstrated that compared to low exercise HR appeared to increase at maximal exercise more in relation to VO2 but less in relation to VE; in men the individual slopes for HR-VO2 were 2.6 +/- 0.7 below but 3.2 +/- 1.0 above AT (P < 0.05) and the slopes for HR-VE were 1.6 +/- 0.5 below but 1.0 +/- 0.4 above AT (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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