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A sensitive and accurate UV spectrophotometric method with multivariate calibration technique for the determination of metformin hydrochloride in bulk drug and different pharmaceutical formulations has been described. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelength. The results were treated statistically and were found highly accurate, precise and reproducible. The method is accurate, precise (% recovery 102.50±0.063, CV≤0.56, r =0.997) and linear within the range 1-10 μg/ml. There was no interference from the excipients i.e Povidone K 30, magnesium stearate, lactose and hydroxypropylmethylcellulose. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions.

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Co-administration of statins with angiotensin converting enzyme inhibitors is most common, since there is strong synergy between hypertension and hypercholesterolemia in terms of risk factors for the development of cardiovascular diseases. Rapid liquid chromatographic procedure proposed for analysis of captopril and statins in pharmaceutical preparations and human serum using acetonitrile:water (60:40 v/v) as a mobile phase, adjusting pH to 2.9 with UV detection at 230 nm. The advantages of this method include good and rapid separation, well resolved peaks, and only a small amount of sample is required for assay and adequate precision. The method showed good linearity in the range of 2.5-100 mgmL -1 for captopril and 0.625-25 mgmL -1 for statins with a correlation coefficient of 0.9999. The recovery of captopril and statins (rosuvastatin, atorvastatin and simvastatin) was > 99.9% and > 99.3%, respectively. The proposed method may be used for the quantitative analysis of captopril and statins alone or in combination in bulk drugs, dosage formulations and in human serum.

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