Synthesis, characterization, antibacterial, antifungal and immunomodulating activities of gatifloxacin–metal complexes

Metal Complexes of Enrofloxacin Part I: Preparation, Spectroscopic, Thermal Analyses Studies and Antimicrobial Evaluation

“…All the metal complexes exhibits higher inhibition against all microorganisms tested except S. aureus K1 compared to free enrofloxacin. The biological activity of many fluoroquinolone increased after the coordination with metal 12,14,22,31 and the rate of antimicrobial activity of the metal complexes depending on the following five principal factors, 42−45 (i) the chelate effect, (ii) the nature of coordinated ligands, (iii) the total charge of the complex, (iv) the nature of the ion neutralizing the ionic complex, (v) the nuclearity of the metal center in the complex. According to the overtone concept of all permeability, the lipid membrane that surrounds the cell favors the passage of only lipid soluble materials in which liposolubility is an important factor that controls the antimicrobial activity.…”

Synthesis, structures and antibacterial activities of benzoylthiourea derivatives and their complexes with cobalt

“…Then, it was taken out and attached to a tablet. Each medium evenly puts eight wafers (including PTCB, 2FPTCB, 4FPTCB, MTCB, 2FMTCB, 4FMTCB, Co(PTCB) 3 , Co(2FPTCB) 3 , Co(4FPTCB) 3 , Co(MTCB) 3 , Co(2FMTCB) 2 and Co(4FMTCB) 3 of the same concentration and DMSO for reference, CoCl 2 for comparison). Each test solution was used for three tablets repeatedly.…”

“…A summary of the crystallographic information and the selected bond lengths and bond angles are listed in Tables 1-2 respectively. The final fractional coordinates, temperature parameters, bond distances and bond angles have been deposited in the Cambridge Crystallographic Data Centre as CCDC 836546 (Co(PTCB) 3 ), 855878 (Co(2FPTCB) 3 ), 855877 (Co(4FPTCB) 3 ), 876734 (Co(2FMTCB) 2 ) and 876735 (Co(4FMTCB) 3 ).…”

“…Antibacterial agents have increased markedly in recent years [1][2][3][4][5][6][7][8][9][10][11][12][13][14] due to the emergence and diversity of drug-resistant strains, the demand for novel. So far, many researchers have studied a variety of compounds to determine their biological activity including antibacterial activity [15][16][17][18][19][20][21][22][23][24].…”

“…Selecting Co complexes as the main subjects for the study, we conceive that the antibacterial effect of cobalt(III) ion had been known, their complexes still being under study in order to find effective antibacterial agents [83][84][85][86][87][88][89]. In the present work, we investigate the antibacterial properties of six thiourea derivatives, named N-(piperidylthiocarbonyl) benzamide (PTCB), N-(piperidyl-thiocarbonyl) 2-fluorobenzamide (2FPTCB), N-(piperidylthiocarbonyl)-4-fluoro-benzamide (4FPTCB), N-(morpholinothiocarbonyl) benzamide (MTCB), N-(morpholinothiocarbonyl)-2-fluorobenzamide (2FMTCB) and N-(morpholinothio-carbonyl)-4-fluorobenzamide (4FMTCB) (Scheme 1) and their cobalt complexes, Co(PTCB) 3 , Co(2FPTCB) 3 , Co(4FPTCB) 3 , Co(MTCB) 3 , Co(2FMTCB) 2 and Co(4FMTCB) 3 against the bacteria E. coli, Staphylococcus aureus, B. subtilis, P. aeruginosa and Shewanella sp. The purpose is to explore the potential antibacterial reagents of thiourea derivatives.…”